Cancer Drugs Database | Anticancerfund

Cancer Drugs Database

CancerDrugs_DB is a curated listing of licensed cancer drugs produced by the Anticancer Fund. Source data comes from the NCI, FDA, EMA and other data sources. The intention is to provide researchers, clinicians and regulators with an easily filtered database of licensed drugs used in the treatment of cancer. Drugs which are used in cancer treatments to alleviate symptoms or other supportive care uses or which are used for diagnostic purposes are not included. Investigational agents and experimental treatments being used in clinical trials are also not included.

Cite as: Pan Pantziarka, Rica Capistrano I, Arno De Potter, Liese Vandeborne, Gauthier Bouche (2021). An Open Access Database of Licensed Cancer Drugs Frontiers in Pharmacology, 11 March 2021 DOI: 10.3389/fphar.2021.627574

A machine-readable version of this database can be downloaded here: cancerdrugsdb.txt. The ReDO database of repurposing candidates in oncology can be accessed here: ReDO_DB.


Summary results as of last build on: 14/11/22NumberPercentage
Number of licensed anticancer drugs290
FDA approved anticancer drugs26190.00%
EMA approved anticancer drugs19667.59%
Euro nationally approved anticancer drugs5017.24%
Non-FDA/EMA/European103.45%
Drugs included in WHO EML5518.97%
Single API drugs28698.62%
Combination (>1 API) drugs41.38%


Click in header cell to sort table by that column. Hover over header cell for additional text.

Database build date: 14/11/22

Number of drugs in database: 290 (Filter not active)



Product EMA FDA EN Other WHO Year Generic DrugBank ID ATC ChEMBL Indications Targets Last Update
Abemaciclib Y Y N N 2017 N DB12001 L01EF03 CHEMBL3301610 Advanced Breast Cancer; Metastatic Breast Cancer CDK6; CDK4; CCND1; CCND3; CDKN2A; NRAS; CCND2; SMARCA4; KRAS 01/02/2022
Abiraterone Y Y N Y 2011 Y DB05812 L02BX03 CHEMBL254328 Metastatic Castration Resistant Prostate Cancer CYP17A1; DSE; TSPYL1; PTEN 14/11/2022
Acalabrutinib Y Y N N 2017 N DB11703 L01EL02 CHEMBL3707348 Chronic Lymphocytic Leukaemia (CLL); Mantle Cell Lymphoma (MCL); Small Lymphocytic Lymphoma BTK 22/06/2022
Aclarubicin N N N Japan N DB11617 L01DB04 CHEMBL502620 SMN1; TOP2B; CSF2 22/09/2020
Afatinib Y Y N Y 2013 N DB08916 L01EB03 CHEMBL1173655 Metastatic Non-Small Cell Lung Cancer; Refractory, metastatic squamous cell Non-small cell lung cancer EGFR; ERBB2; ERBB4; KRAS; EML4; MET; BRAF; NRG1; NRAS; ERBB3 01/02/2022
Aflibercept Y Y N N 2011 N DB08885 S01LA05; L01XX44 CHEMBL1742982 Metastatic Colorectal Cancer (MCRC) VEGFA; VEGFB; PGF; PIGF; VEGFC 17/09/2020
Aldesleukin N Y Y N 1992 N DB00041 L03AC01 CHEMBL1201438 High Risk Neuroblastoma; Metastatic Melanoma; Metastatic Renal Cell Carcinoma IL2RG; IL2RB; IL2RA; IL2 17/09/2020
Alectinib Y Y N N 2015 N DB11363 L01ED03 CHEMBL1738797 Refractory, metastatic Non small cell lung cancer ALK; FGFR1; EML4; NPM1; CDKN2A; SMAD4; RET 01/02/2022
Alemtuzumab Y Y N N 2001 N DB00087 L04AA34 CHEMBL1201587 B-Cell Chronic Lymphocytic Leukemia; T-Cell Prolymphocytic Leukemia CD52; CXCL12 17/09/2020
Alitretinoin Y Y N N 1999 N DB00523 D11AH04; L01XF02 CHEMBL705 RXRG; RARA; RXRA; RXRB; RARB; RARG 22/06/2022
Alpelisib Y Y N N 2019 N DB12015 L01EM03 CHEMBL2396661 Advanced Metastatic Breast Cancer PIK3C2B; PIK3R4; PIK3C2A; PIK3R1; PIK3R6; PIK3R3; PIK3CA; PIK3R5; PIK3R2; PIK3C2G; PIK3C3; BRAF; SGK1; PI4KA; RB1; PTEN; CDK4 01/02/2022
Altretamine N N Y N 1990 N DB00488 L01XX03 CHEMBL1455 Ovarian Cancer; Ovarian Cancer Stage III CYP1A2 01/02/2022
Aminolevulinic Acid Y Y N N 1999 N DB00855 L01XD04 CHEMBL601 Basal Cell Carcinoma (BCC); Squamous Cell Carcinoma (SCC) 17/09/2020
Amivantamab Y Y N N 2021 N DB16695 L01FX18 CHEMBL4297774 Locally Advanced Non-Small Cell Lung Cancer, Metastatic Non-Small Cell Lung Cancer EGFR; MET 31/01/2022
Amrubicin N N N Japan N 2002 DB06263 L01DB10 CHEMBL1186894 TOP2A 22/09/2020
Amsacrine N N N N 1987 N DB00276 L01XX01 CHEMBL43 Leukemia, Acute; Refractory Leukemia TOP2A; TOP2B; BTF3P11 01/02/2022
Anastrozole N Y Y Y 1995 Y DB01217 L02BG03 CHEMBL1399 Advanced Breast Cancer; Early Breast Cancer; Locally Advanced Breast Cancer (LABC); Metastatic Breast Cancer; Invasive, early Breast Cancer CYP19A1; TUBB1; TNFRSF11B; PGR; MAP4K4; UGT1A4; CYP1B1; IGF2; KMT2C; TNFSF11 14/11/2022
Apalutamide Y Y N N 2018 N DB11901 L02BB05 CHEMBL3183409 Nonmetastatic Prostate Cancer AR 17/09/2020
Arsenic Trioxide Y Y N Y 2018 Y DB01169 L01XX27 CHEMBL1200978 Refractory Acute Promyelocytic Leukemia TXNRD1; TXNRD2 14/11/2022
Asciminib Y Y N N 2021 N DB12597 L01EA06 CHEMBL4208229 Philadelphia chromosome-positive chronic myeloid leukemia in chronic phase ABL1 23/10/2022
Asparaginase Y Y N Y 1994 N DB00023 L01XX02 CHEMBL2108989 Acute Lymphoblastic Leukaemias (ALL) CPA2; NOTCH1; LPL; ETV6; ASNS; TYMSOS; GATA3; HLA-DRB1; PYGL; GRIA1; TYMS; NFATC2; PNPLA3; SOD2; RB1 01/02/2022
Atezolizumab Y Y N N 2016 N DB11595 L01FF05 CHEMBL3707227 Metastatic Non-Small Cell Lung Cancer; Small Cell Lung Cancer (SCLC); Triple Negative Breast Cancer (TNBC); Urothelial carcinoma ureter metastatic; Locally advanced Urothelial Carcinoma CD274; KRAS; ARID1A; CTLA4; JAK3; MDM4; ALK; STK11; HLA-DRA; CX3CL1; EGFR; PBRM1 01/02/2022
Avapritinib Y Y N N 2020 N DB15233 L01EX18 CHEMBL4204794 Metastatic Gastrointestinal Stromal Tumor; Unresectable Gastrointestinal stromal tumor KIT; PDGFRA 17/09/2020
Avelumab Y Y N N 2017 N DB11945 L01FF04 CHEMBL3833373 Locally advanced disease has progressed during or following platinum-containing chemotherapy urothelial carcinoma (UC); Locally advanced disease has progressed within 12 months of neoadjuvant or adjuvant treatment with platinum-containing chemotherapy urothelial carcinoma (UC); Metastatic Merkel Cell Carcinoma (MCC); Metastatic disease has progressed during or following platinum-containing chemotherapy urothelial carcinoma (UC); Metastatic disease has progressed within 12 months of neoadjuvant or adjuvant treatment with platinum-containing chemotherapy urothelial carcinoma (UC) CD274; EGFR 01/02/2022
Axicabtagene Ciloleucel Y Y N N 2017 N DB13915 L01XX70 CHEMBL3989989 Refractory Diffuse large B-cell lymphoma NOS; Refractory High grade B-cell lymphoma Burkitt-like lymphoma; Refractory Primary Mediastinal Large B-Cell Lymphoma; Relapsed Diffuse large B-cell lymphoma NOS; Relapsed High grade B-cell lymphoma Burkitt-like lymphoma; Relapsed Primary Mediastinal Large B-Cell Lymphoma 17/09/2020
Axitinib Y Y N N 2012 N DB06626 L01EK01 CHEMBL1289926 Advanced Thyroid cancer FLT1; KDR; PDGFB; KIT; FLT4; PDGFRB; ABL1; UGT1A1; CYP3A5 22/06/2022
Azacitidine Y Y N N 2004 Y DB00928 L01BC07 CHEMBL1489 Acute Myeloid Leukemia (AML); Chronic Myelomonocytic Leukemia DNMT1; DNMT3A; GGT1; CD247; AFP; ASXL1; TG; IL11; TAGLN; PLAU; MGMT; LIF; TRIT1; TYMS; GATA2; CDA; TET2 14/11/2022
BCG Vaccine Y Y N Y DB12768 L03AX03 CHEMBL2108905 Non-Invasive Bladder Urothelial Carcinoma; Recurrent Superficial Bladder Cancer; Urothelial Carcinoma Recurrent; Carcinoma in situ of urinary bladder 22/09/2020
Belantamab Mafodotin Y Y N N 2020 N DB15719 L01FX15 CHEMBL4298209 Relapsed Or Refractory Multiple Myeloma 01/02/2022
Belinostat N Y N N 2014 N DB05015 L01XH04 CHEMBL408513 Relapsed Peripheral T-Cell Lymphoma; Refractory Peripheral T-cell Lymphoma Unspecified HDAC2; HDAC5; HDAC4; HDAC10; HDAC7; HDAC11; HDAC9; HDAC1; HDAC3; HDAC6; HDAC8; UGT1A1; FBXW7 01/02/2022
Belotecan N N N South Korea N 2003 DB12459 L01CE04 CHEMBL2111084 22/09/2020
Bendamustine N Y Y Y 2008 Y DB06769 L01AA09 CHEMBL487253 Chronic Lymphocytic Leukaemia (CLL); Follicular Non-Hodgkin's Lymphoma Refractory; Refractory Hodgkin Lymphoma; Refractory Mantle Cell Lymphoma; Waldenstrom's Macroglobulinemia (WM); Recurrent multiple myeloma; Refractory indolent B cell non-hodgkin lymphoma ATM 01/02/2022
Bevacizumab Y Y N Y 2004 N DB00112 S01LA08; L01FG01 CHEMBL1201583 Cervical Cancer Metastatic; Metastatic Colorectal Cancer (MCRC); Metastatic Non-Squamous Non-Small Cell Lung Cancer; Metastatic Renal Cell Carcinoma; Persistent Cervical Cancer; Recurrent Cervical Cancer; Recurrent Glioblastoma; Stage III epithelial ovarian cancer following initial surgical resection; Stage IV epithelial ovarian cancer following initial surgical resection; Fallopian tube cancer following initial surgical resection; Locally advanced nonsquamous non-small cell lung cancer; Primary peritoneal cancer following initial surgical resection; Recurrent Non-Squamous Non-Small Cell Lung Cancer; Recurrent Platinum-Sensitive Epithelial Ovarian Cancer; Recurrent Platinum-resistant Epithelial Ovarian Cancer; Recurrent platinum drug resistant Fallopian tube cancer; Recurrent platinum drug resistant primary peritoneal cancer; Recurrent platinum sensitive primary peritoneal cancer; Recurrent platinum-sensitive fallopian tube cancer; Unresectable Non-Squamous Non-Small-Cell Lung Cancer VEGFA; PRKCA; EDN1; VEGFC; MGAT4A; VEGFB; RGS5; THBS2; ARMS2; SHMT1; CFH; GGH; HSP90AB1; MTHFR; VHL; HRAS; CXCR4; BRAF; GC; MMP9; MMP2; HTRA1 01/02/2022
Bexarotene Y Y N N 1999 Y DB00307 L01XF03 CHEMBL1023 Refractory peripheral cutaneous T-cell lymphoma RXRG; RXRA; RXRB; NR1H3; MAPK8 14/11/2022
Bicalutamide N Y Y Y 1995 Y DB01128 L02BB03 CHEMBL409 Stage D2 Prostatic carcinoma AR; CFLAR; BAX; CYP2B6; FST; KLK3 01/02/2022
Binimetinib Y Y N N 2018 N DB11967 L01EE03 CHEMBL3187723 Metastatic Melanoma; Unresectable Melanoma MAP2K1; MAP2K3; MAP2K2; MAP2K5; MAP2K6; MAP2K7; MAP2K4; BRAF; NF1; KRAS; APC; ATM; PTEN; GNAQ; UGT1A1; NRAS; GNA11; HRAS 01/02/2022
Bleomycin N Y Y Y 1973 Y DB00290 L01DC01 CHEMBL403664 Cervical Cancers; Head and Neck Carcinoma; Intracranial Germ Cell Tumors; Lymphoma, Hodgkins; Malignant Pleural Effusions; Non-Hodgkin's Lymphoma (NHL); Ovarian Cancer; Penile Cancer; Testicular Cancer; Vulvar Cancers; Early Kaposi's sarcoma LIG1; F2R; CTLA4; GJA1; MAPK8; AFP; ADK; ERCC2; GSTM1; CCL17; SMAD2; ERCC1; IFNG 01/02/2022
Blinatumomab Y Y N N 2014 N DB09052 L01FX07 CHEMBL1742992 Precursor B-Lymphoblastic Lymphoma/Leukaemia Refractory; Relapsed B cell precursor Acute lymphoblastic leukemia CD19; CD3E; CD3D; BCR; ABL1; CD247; CD3G 01/02/2022
Bortezomib Y Y N Y 2003 Y DB00188 L01XG01 CHEMBL325041 Mantle Cell Lymphoma (MCL); Multiple Myeloma (MM) PSMC2; PSMD4P1; PSMD11; PSMB3; PSMD3; PSMA8; PSMB10; PSMC3IP; PSMD14; PSMD8; PSMD13; PSMC1P1; PSMD10P2; PSME3; PSMB1; PSMD9; PSMD10P3; PSMD6; PSMD12; PSMC3; PSME2P2; PSMA1; PSMD4; PSMC4; PSMB8; PSMD2; PSME1; PSMD10; PSMD5; PSMA6; PSMD1; PSMA3; PSME2; PSMA4; PSMC5; PSMC1; PSMB6; PSMB5; PSMB4; PSMB9; PSME4; PSMA2; PSMB7; PSMD7; PSMB2; PSMB11; PSMA7; ADRM1; PSMA5; PSMF1; PSMC6; PIPSL; PSMD10P1; SEM1; BCL2L2; PRSS1; PMAIP1; CTSB; KLK4; PRSS3; F12; PRSS2; GATA2; CAPN1; HSPB2; PRB2; PLAT; CTSL 14/11/2022
Bosutinib Y Y N N 2010 N DB06616 L01EA04 CHEMBL288441 Refractory, accelerated phase Chronic myelogenous leukemia; Refractory, blast phase Chronic myelogenous leukemia; Refractory, chronic phase Chronic myelogenous leukemia HCK; ABL1; SRC; LYN; BCR; EGFR 22/06/2022
Brentuximab vedotin Y Y N N 2011 N DB08870 L01FX05 CHEMBL1742994 B-large cell anaplastic Lymphoma (Kiel Classification) refractory; Refractory Hodgkin Lymphoma; Post-autologous hematopoietic stem cell transplantation Hodgkin lymphoma TUBB2B; TUBB8; TUBB6; TUBA4A; TUBB3; TUBB2A; TUBA3E; TUBA1C; TUBA1A; TUBA1B; TUBB4B; TNFRSF8; TUBA3D 01/02/2022
Brexucabtagene Autoleucel Y Y N N 2020 N DB15699 Refractory Mantle Cell Lymphoma; Relapsed Mantle Cell Lymphoma 26/10/2020
Brigatinib Y Y N N 2017 N DB12267 L01ED04 CHEMBL3545311 Metastatic Non-Small Cell Lung Cancer ALK; EGFR; ROS1 22/06/2022
Buserelin N N Y N 2017 N DB06719 L02AE01 CHEMBL2110824 Stage D2 Prostatic carcinoma GNRHR; IGFBP1 22/09/2002
Busulfan Y Y N N 1954 Y DB01008 L01AB01 CHEMBL820 Essential Thrombocythemia (ET); Polycythemia Vera (PV); Chronic Chronic myelogenous leukemia GSTA1; THPO; BCR; GSTM1; GALC; ITGAL; CTH; GSTP1; CYP2B6; ADK; G6PD; ABL1 01/02/2022
Cabazitaxel Y Y N N 2010 N DB06772 L01CD04 CHEMBL1201748 Refractory, metastatic hormone-refractory Prostate cancer TUBB1; TUBA4A; IGF2; TUB 22/06/2022
Cabozantinib Y Y N N 2012 N DB08875 L01EX07 CHEMBL2105717 Advanced Renal Cell Carcinoma; Hepatocellular Carcinoma; Metastatic Clear Cell Renal Cell Carcinoma; Progressive, metastatic Medullary thyroid cancer RET; KDR; MET; FLT3; KIT; TEK; GNA11; CFLAR; ROS1; HRAS 01/02/2022
Calaspargase Pegol N Y N N 2018 N DB14730 CHEMBL2108728 Acute Lymphoblastic Leukaemias (ALL) 17/09/2020
Capecitabine Y Y N Y 1998 Y DB01101 L01BC06 CHEMBL1773 Duke's C Colon cancer; Esophageal Cancers; Hepatobiliary Cancers; Malignant Neoplasm of Stomach; Metastatic Breast Cancer; Metastatic Colorectal Carcinoma; Pancreatic Cancer Metastatic; Refractory Fallopian Tube Carcinoma; Metastatic pancreatic endocrine carcinoma; Refractory Ovarian cancer; Refractory peritoneal cancer; Refractory, metastatic Colorectal carcinoma TYMS; MGAT4A; DLG5; CDH1; DPYD; VEGFA; CYP1A1; MTHFR; UMPS; EXO1; AREG; MIR2054; MIR27A; ADCY2; CES1P1; TYMP; CDA; ERBB2; ERCC1; SELE; ENOSF1; CES1; HLA-G; TYMSOS; SLC22A7; REV3L 14/11/2022
Capmatinib Y Y N N 2020 N DB11791 L01EX17 CHEMBL3188267 Metastatic Non-Small Cell Lung Cancer MET; EGFR; BRAF 22/06/2022
Carboplatin N Y Y Y 1989 Y DB00958 L01XA02 CHEMBL1351 Advanced Cervical Cancer; Advanced Endometrial Cancer; Advanced Esophageal Cancers; Advanced Head and Neck Cancer; Advanced Melanoma; Advanced Non Small Cell Lung Cancer; Advanced Ovarian Carcinoma; Advanced Sarcoma; Metastatic Breast Cancer; Neuroendocrine Carcinoma of the Skin; Pleural mesothelioma malignant; Refractory Hodgkin Lymphoma; Retinoblastoma; Advanced Bladder cancer; Advanced Small cell lung cancer; Advanced Testicular cancer; Advanced Thymoma; Advanced thymic carcinoma; Refractory Non-Hodgkin's lymphoma GCLC; ATP7A; GPX5; PRRC2A; XRCC1; TP73; SOX10; C6ORF15; EIF3A; ACSS2; ERCC1; MTHFR; DOCK8; MAP3K1; HLA-C; FNTB; DSCAM; MSH5; SLC31A1; TRIM5; MAD1L1; ATP7B; ATAT1; SMAD4; SERPINA5; ETS2; MUCL3; XYLT2; PSORS1C1; NF2; ERCC2; CDSN; MTR; BARD1; RNF8; GSR; SLCO1B3; PPP1R18; SLC19A1; HCP5 14/11/2022
Carfilzomib Y Y N N 2009 N DB08889 L01XG02 CHEMBL451887 Refractory Multiple Myeloma; Waldenstrom's Macroglobulinemia (WM) PSMB2; PSMD14; PSMB8; PSMD13; PSMC6; PSMC5; PSMA6; PSMD6; PSMC1; PSMA5; PSME2; PSMA2; PSMB5; PSMA3; PSMD10P2; PSMB9; PSMD3; PSMB7; PIPSL; PSMA7; PSMB4; PSMD4; SEM1; PSMC3; PSMB6; PSMD2; PSMD7; PSMD12; PSMC4; PSMB10; PSMA1; PSMD5; PSMD8; PSMC2; PSMB11; PSMA4; PSMD11; PSMD1; PSMB1; ADRM1; PSMA8; PSMB3; PSME1; PSMD10P3; PSME2P2; PSMD4P1; PSMC1P1; PSME4; PSME3; PSMD10; PSMD10P1; PSMF1; PSMD9; PSMC3IP; PRB2 17/09/2020
Carmofur N N N Japan N DB09010 L01BC04 CHEMBL460499 28/10/2021
Carmustine Y Y N N 1977 Y DB00262 L01AD01 CHEMBL513 Astrocytomas; Brain Stem Gliomas; Ependymomas; Glioblastomas; Medulloblastomas; Mycosis Fungoides (MF); Recurrent Glioblastoma Multiforme; Refractory Hodgkin Lymphoma; Refractory Multiple Myeloma; Tumors Metastatic to Brain; High grade newly diagnosed Glioma; Refractory Non-Hodgkin's lymphoma GSR; G6PD; MGMT; PLAU; E2F1 14/11/2022
Carmustine Implant Y Y N N 1977 Y DB00262 L01AD01 CHEMBL513 Astrocytomas; Brain Stem Gliomas; Ependymomas; Glioblastomas; Medulloblastomas; Mycosis Fungoides (MF); Recurrent Glioblastoma Multiforme; Refractory Hodgkin Lymphoma; Refractory Multiple Myeloma; Tumors Metastatic to Brain; High grade newly diagnosed Glioma; Refractory Non-Hodgkin's lymphoma GSR; G6PD; MGMT; PLAU; E2F1 14/11/2022
Cemiplimab Y Y N N 2018 N DB14707 L01FF06 CHEMBL4297723 Metastatic cutaneous squamous cell carcinoma; Locally advanced cutaneous squamous cell carcinoma, and not a candidate for curative surgery or curative radiation PDCD1; CDK12 01/02/2022
Ceritinib Y Y N N 2014 N DB09063 L01ED02 CHEMBL2403108 Refractory, locally advanced Non-small cell lung cancer; Refractory, metastatic Non small cell lung cancer IGF1R; ALK; INSR; TSSK1B; SRC; MAP2K1; EML4; ROS1; NPM1 01/02/2022
Cetuximab Y Y N N 2004 N DB00002 L01FE01 CHEMBL1201577 Locally Advanced Squamous Cell Carcinomas of the Head and Neck (SCCHN); Metastatic Colorectal Cancer (MCRC); Metastatic Squamous Cell Carcinoma of the Head and Neck; Recurrent Squamous Cell Carcinoma of the Head or Neck; Regionally Advanced Squamous Cell Carcinoma of the Head and Neck EGFR; CCND1; MGAT4A; NRAS; FCGR3A; HBEGF; NT5E; ERBB3; NRG2; BTC; FCGR2A; AREG; MAP2K1; SMAD4; DNTT; BRAF; NRG3; RARA; NRG1; CXCL8; EGF; HNF4A; GC; TGFA; VPS37A; EREG; PIK3CA; EPO; KRAS; PTP4A3 01/02/2022
Chlorambucil N Y Y Y 1957 N DB00291 L01AA02 CHEMBL515 Chronic Lymphocytic Leukaemia (CLL); Hodgkins Disease (HD); Non-Hodgkin's Lymphoma (NHL); Waldenstrom's Macroglobulinemia (WM); Giant follicular lymphoma BRCA1; MGMT; GFER; CXCL12; GSTM1; BRCA2; FANCC 01/02/2022
Chlormethine Y Y N N 1949 N DB00888 L01AA05 CHEMBL427 Carcinoma, Bronchogenic; Chronic Lymphocytic Leukaemia (CLL); Hodgkins Disease (HD); Lymphoma, Diffuse; Mycosis Fungoides (MF); Polycythemia Vera (PV); Stage I Mycosis Fungoides; Malignant effusion CSF2 17/09/2020
Ciltacabtagene Autoleucel Y Y N N 2022 N DB16738 L01XL05 CHEMBL4802263 Refractory Multiple Myeloma, Relapsed Multiple Myeloma 23/10/2022
Cisplatin N Y Y Y 1978 Y DB00515 L01XA01 CHEMBL2068237; CHEMBL11359 Advanced Pancreatic Cancer; Breast Cancer; Cervical Cancers; Esophageal Cancers; Head and Neck Carcinoma; Hepatobiliary Cancers; Hepatoblastomas; Malignant Neoplasm of Stomach; Medulloblastomas; Metastatic Melanoma; Multiple Myeloma (MM); Neuroblastomas; Non-Small Cell Lung Carcinoma (NSCLC); Ovarian Cancer Metastatic; Pleural Mesotheliomas; Primary Central Nervous System Lymphoma (PCNSL); Recurrent Endometrial Cancer; Refractory Hodgkin Lymphoma; Sarcoma, Osteogenic; Small Cell Lung Cancer (SCLC); Thymic Cancer; Advanced Bladder cancer; Metastatic Anal cancer; Metastatic Endometrial cancer; Metastatic Penile cancer; Metastatic Testicular cancer; Refractory Non-Hodgkin's lymphoma ERCC2; POLR1G; GADD45A; ACYP2; SLC22A2; CMPK1; MDH2; GCLM; STAT1; CSNK2A3; RARS1; FANCA; UBE2I; REV3L; HMGB1; LRP2; LIG3; XRCC5; REV1; ERCC1; MIR21; GPX5; COMT; H2AW; MTHFR; OTOS; KLC3; DRAM1; GCLC; SMARCA4; BIRC7; AQP9; DCBLD1; GALNT18; XPC; GABPA; MT1F; BRCA2; DFFB; ATR; ADH1C; NF2; MAP3K1; GRP; ATP7B; PPP1R13L; GALNT14; MUTYH; EPHX1; GSTP1; EIF3A; RRM1; MLLT3; MTR; LIF; TP73; KRT20; TERC; MT1H; FXN; SLC31A1; ACSS2; CDH17; FANCC; CDC25C; SLC16A5 22/06/2022
Cladribine Y Y N N 1993 Y DB00242 L04AA40; L01BB04 CHEMBL1619 Chronic Lymphocytic Leukaemia (CLL); Cutaneous T-Cell Lymphoma (CTCL); Hairy Cell Leukemia (HCL); Non-Hodgkin's Lymphoma (NHL) RRM2B; RRM1; RRM2; DIABLO; NT5C1A; XIAP; DCK; BCL2L2; TGFB1; ADA; CDKN1A; IL2RA 17/09/2020
Clofarabine Y Y N N 2004 Y DB00631 L01BB06 CHEMBL1750 Acute Lymphoblastic Leukaemia Recurrent; Refractory Acute Lymphoblastic Leukemia; Refractory Acute Myelogenous Leukemia (AML); Refractory Langerhans cell histiocytosis POLA1; RRM1; RRM2; POLE; RRM2B; POLD1; APBB1 14/11/2022
Cobimetinib Y Y N N 2015 N DB05239 L01EE02 CHEMBL2146883 Metastatic Melanoma; Unresectable Melanoma MAP2K1; MAP2K7; MAP2K2; MAP2K6; MAP2K3; MAP2K4; MAP2K5; RAF1; ARAF; BRAF; KRAS; NF1 01/02/2022
Copanlisib N Y N N 2017 N DB12483 L01EM02 CHEMBL3218576 Relapsed Follicular Lymphoma PIK3C2B; PIK3CD; PIK3C2A; PIK3R6; PIK3R3; PIK3CA; PIK3CG; PIK3R1; PIK3R2; PIK3CB; PIK3R5; PIK3C2G; PIK3R4; PIK3C3; PTEN 01/02/2022
Crizotinib Y Y N N 2011 N DB08865 L01ED01 CHEMBL601719 Metastatic Non-Small Cell Lung Cancer MET; ROS1; ALK; EML4; NPM1; ETV6; PTPN12; SMAD4; AREG; EGFR; CDKN2A; NTRK1; KRAS 01/02/2022
Cyclophosphamide N Y Y Y 1959 Y DB00531 L01AA01 CHEMBL88 Acute Lymphoblastic Leukaemias (ALL); Acute Myelocytic Leukemia; Adenocarcinoma of the Ovaries; Breast Cancer; Burkitt's Lymphoma; Chronic Lymphocytic Leukaemia (CLL); Chronic Myeloid Leukemia (CML); Disseminated Neuroblastoma; Ewing's Sarcoma; Lung Cancers; Lymphoma, Hodgkins; Multiple Myeloma (MM); Non-Hodgkin's Lymphoma (NHL); Ovarian germ cell tumour; Pheochromocytomas; Retinoblastoma; Rhabdomyosarcomas; Waldenstrom's Macroglobulinemia (WM); Advanced Alibert-Bazin syndrome; Histiocytic lymphoma; Metastatic gestational trophoblastic tumor; Mixed-cell type lymphoma; Refractory Small cell lung cancer; Relapsed Wilm's tumor SLC22A16; NOS3; QUINONE REDUCTASE 2; GNL3; XRCC1; ERCC1; CYP2A6; IL5; CYP2B6; TP53AIP1; PNPLA3; DROSHA; LINC00251; BMP7; MUTYH; CBR1; CBR3; LIG3; ALDH3A1; IRS1; HMMR; PERP; ACTB; GSTP1; CXCL12; PPP2R5D; DOK5; SOD2; CCNK; NTF3; RBX1; TPMT; EPHX1; TNFRSF1A; GSTA1; ADH1C; FOXO1; MYCN; CTH; NAT2; GATA3 01/02/2022
Cytarabine Y Y N Y 1969 Y DB00987 L01BC01 CHEMBL803 Acute Lymphocytic Leukemia (ALL); Acute Myeloid Leukemia (AML); Acute Promyelocytic Leukemia (APL); Leptomeningeal Metastases; Meningeal leukemia; Non-Hodgkin's Lymphoma (NHL); Blast phase Chronic myelocytic leukemia POLE; POLA1; POLD1; SLC22A12; DROSHA; CYP2E1; RRM2B; NT5C2; GATA1; GATA3; ABCC4; IKZF1; NT5C3A; RRM2; WT1; NCOA3; DCK; TYMSOS; MED12L; LINC00251; RRM1; CDA; DOK5; P2RY12; BMP7; SULT2B1 14/11/2022
Dabrafenib Y Y N N 2013 N DB08912 L01EC02 CHEMBL2028663 Metastatic Melanoma; Unresectable Melanoma BRAF; CDKN2A; HLA-DRB1; STAG2; NRAS; ATXN1L; MITF; EZH2; MAP2K2; RAC1; MAP2K1; HRAS; NF1 01/02/2022
Dacarbazine N Y Y Y 1975 Y DB00851 L01AX04 CHEMBL476 Advanced Soft Tissue Sarcoma; Lymphoma, Hodgkins; Metastatic Melanoma; Pheochromocytomas; Advanced Medullary thyroid cancer; Advanced Pancreatic neuroendocrine tumor POLA2; PLAU; ADK; BAX; MGMT; CYP1A1; GSTM1 17/09/2020
Dacomitinib Y Y N N 2018 N DB11963 L01EB07 CHEMBL2110732; CHEMBL2105719 Metastatic Non-Small Cell Lung Cancer EGFR; ERBB3; ERBB4; ERBB2; PTEN 17/09/2020
Dactinomycin N Y N Y 1964 Y DB00970 L01DA01 CHEMBL1554 Ewing's Sarcoma; Ovarian Cancer; Rhabdomyosarcomas; Sarcoma, Osteogenic; Wilms' tumor; Metastatic nonseminomatous Testicular cancer 14/11/2022
Daratumumab Y Y N N 2015 N DB09331 L01FC01 CHEMBL1743007 Multiple Myeloma (MM); Refractory Multiple Myeloma; Relapsed Multiple Myeloma; Relapsed Or Refractory Multiple Myeloma CD38 01/02/2022
Daratumumab, Hyaluronidase N Y N N 2015 N DB09331 L01XC24 CHEMBL1743007 Multiple Myeloma (MM); Refractory Multiple Myeloma; Relapsed Multiple Myeloma; Relapsed Or Refractory Multiple Myeloma CD38 17/09/2020
Darolutamide Y Y N N 2019 N DB12941 L02BB06 CHEMBL4297185 Non-mestatatic castrate-resistant prostate cancer AR 17/09/2020
Dasatinib Y Y N Y 2006 Y DB01254 L01EA02 CHEMBL1421 Acute Lymphoblastic Leukaemias (ALL); Chronic Myeloid Leukemia (CML) ABL2; BRAF; HCK; KIT; PDGFRB; SRC; EPHA2; FGR; FYN; ABL1; BCR; LCK; SIK2; STAT5B; DDR2; SRMS; ABI1; TEC; PTK6; CRKL; ARID1A; FES; PDGFRA; CBL; MAP3K10; MAP3K20; CDC42BPA; IDH2 22/06/2022
Daunorubicin N Y Y Y 1979 Y DB00694 L01DB02 CHEMBL178 Acute Lymphocytic Leukemia (ALL); Acute Myeloid Leukemia (AML); Acute Myeloid Leukemia With Myelodysplasia-Related Changes; Acute erythroid leukemia; Acute monocytic leukaemia; Newly diagnosed Therapy-Related Acute Myeloid Leukemia ATP7B; DCK; AKR1C3; BMP7; CBR1; SETD4; GATA1; RPSA; NRP2; LINC00251; FMO3; WT1; DOK5; GATA3; FAS; DROSHA; CBR3; IKZF1; PNPLA3; SLC28A3; AKR1C4; AKR7A2 01/02/2022
Daunorubicin, Cytarabine Liposome Y Y N N 2017 Y DB00694 L01XY01; L01DB02 Acute Lymphocytic Leukemia (ALL); Acute Myeloid Leukemia (AML); Acute Myeloid Leukemia With Myelodysplasia-Related Changes; Acute erythroid leukemia; Acute monocytic leukaemia; Newly diagnosed Therapy-Related Acute Myeloid Leukemia 28/10/2021
Decitabine Y Y N N 2006 Y DB01262 L01BC08 CHEMBL1201129 Chronic Myelomonocytic Leukemia; Myelodysplastic Syndromes (MDS) DNMT1; DNMT3A; ASXL1; GSTP1; IL2RA; MUC2; TET2 14/11/2022
Decitabine, Cedazuridine N Y N N 2006 Y DB01262 L01BC08 CHEMBL1201129 Chronic Myelomonocytic Leukemia; Myelodysplastic Syndromes (MDS) DNMT1; DNMT3A; ASXL1; GSTP1; IL2RA; MUC2; TET2 14/11/2022
Degarelix Y Y N N 2008 N DB06699 L02BX02 CHEMBL415606 Advanced Prostate Cancer GNRHR; GNRHR2 17/09/2020
Denileukin Diftitox N Y N N 1999 N DB00004 L01XX29 CHEMBL1201550 Cutaneous T-Cell Lymphoma (CTCL) EEF2; IL2RB; IL2RA; IL2RG 17/09/2020
Denosumab Y Y N N 2010 N DB06643 M05BX04 CHEMBL1237023 Giant cell tumor of the bone; Refractory Hypercalcemia of malignancy TNFSF11; BRCA1 17/09/2020
Dexamethasone Y Y N Y 1958 Y DB01234 S03BA01; S02BA06; S01CB01; S01BA01; R01AD03; H02AB02; D10AA03; D07XB05; D07AB19; C05AA09; A01AC02 CHEMBL384467 Leukemia, Acute; Malignant Lymphomas; Multiple Myeloma (MM); Mycosis Fungoides (MF) ANXA1; IGFBP1; CCL17; CHKA; TDO2; THRSP; RPS19; FOLR1; CDH17; LOH19CR1; UBR1; SAG; BMP7; TJP1; S100A10; GATA3; DOK5; CARTPT; SI; SDS; PYGL; NPPC; TEAD1; JUNB; PZP; SFTPA1; TSC22D3; DPEP1; IRS2; VCAM1; NR5A1; LINC00251; CD86; SOAT1; LIF; MT1F; CHAT; ACTC1; PTH1R; CDK4; TGFBR3; HYAL2; KRT19; HSPA8; F9; FABP1; CRISPLD2 14/11/2022
Dexrazoxane Y Y N N 1995 Y DB00380 V03AF02 CHEMBL1738 TOP2A; MAPK8; CP; ABCB1; TOP2B; DPYS 14/11/2022
Diethylstilbestrol N N Y N 1973 N DB00255 G03CC05; G03CB02; L02AA01 CHEMBL411 ESRRG; ESR1; ESRRB; CP; E2F1; PTGES3; LPO; DNMT1; AMH; MYC; NPPC; BCL2; WNT7A; HRAS 01/02/2022
Dinutuximab Y Y N N 2015 N DB09077 L01XC16 CHEMBL3137342 High Risk Neuroblastoma B4GALNT1; MYCN 17/09/2020
Docetaxel Y Y N Y 1996 Y DB01248 L01CD02 CHEMBL92 Esophageal Cancers; Ewing's Sarcoma; Locally Advanced Breast Cancer (LABC); Metastatic Bladder Cancer; Metastatic Breast Cancer; Metastatic Hormone Refractory Prostate Cancer; Node Positive Breast Cancer; Ovarian Cancer Metastatic; Small Cell Lung Cancer (SCLC); Soft Tissue Sarcoma (STS); Advanced untreated gastric adenocarcinoma; Locally advanced Squamous cell carcinoma of head and neck; Locally advanced untreated non small cell lung cancer; Metastatic Squamous cell carcinoma of head and neck; Metastatic untreated non small cell lung cancer; Refractory, locally advanced Non small cell lung cancer; Refractory, metastatic Non small cell lung cancer TUBA3D; TUBA4A; TUBA1B; TUBA3E; TUBB8; TUBB2B; TUBB4B; TUBA1A; TUBA1C; TUBB3; TUBB6; TUBB2A; FOLH1; SLC10A2; EPHX1; RRM1; CYP4B1; IGF2; PGP; BRD4; SOX10; XRCC1; PPCDC; ERCC2; KLK3; BARD1; ATP7A; HNF4A; SPG7; XRCC4; TLE3; RNF8; ORM2; MAP3K1; BCL2; SULT1C4; RPL13; CHST3; MUC16; SNORD68; NR1I3; SLCO1B3; MDM4; VAC14; ABCC6; FBXW7; ACSS2; AKR1C3; PRDX4; GAS6 14/11/2022
Dostarlimab Y Y N N 2021 N DB15627 L01FF07 CHEMBL4298124 Adults with mismatch repair deficient (dMMR) recurrent or advanced endometrial cancer that has progressed on or following prior treatment with a platinum-containing regimen PDCD1 01/02/2022
Doxorubicin N Y Y Y 1974 Y DB00997 L01DB01 CHEMBL53463 Acute Lymphoblastic Leukaemias (ALL); Acute Myeloblastic Leukemia; Advanced Endometrial Cancer; Advanced Soft Tissue Sarcoma; Bladder transitional cell carcinoma; Carcinoma, Bronchogenic; Gastric Carcinoma; Kaposi's Sarcoma AIDS Related; Lymphoma, Hodgkins; Malignant Lymphomas; Metastatic Breast Cancer; Multiple Myeloma (MM); Mycosis Fungoides (MF); Neuroblastomas; Ovarian Cancer Metastatic; Ovarian Carcinoma; Sarcoma, Bone; Sezary Syndrome; Soft Tissue Sarcoma (STS); Thyroid Carcinoma; Waldenstrom's Macroglobulinemia (WM); Wilms' tumor; Advanced Thymoma; Advanced uterine sarcoma TOP2A; ATRX; AFP; ZEB1; MYB; NOS3; NCF4; RPSA; LRP1B; CYBA; GADD45A; PPM1D; EZH2; QUINONE REDUCTASE 2; TAF1; RAC2; SLC28A3; AKR1A1; SLC22A16; MYOD1; EDN1; GSTA1; CBR3; SDHB; LINC00251; H2AX; DOK5; ALDH3A1; GATA3; AKR1C3; CDKN1B; AKR7A2; IL11; CBR1; SP3; SETD4; BMP7 22/06/2022
Doxorubicin Liposome Y Y N N 1998 Y Not found in DrugBank L01DB01 CHEMBL53463 Acute Lymphoblastic Leukaemias (ALL); Acute Myeloblastic Leukemia; Advanced Endometrial Cancer; Advanced Soft Tissue Sarcoma; Bladder transitional cell carcinoma; Carcinoma, Bronchogenic; Gastric Carcinoma; Kaposi's Sarcoma AIDS Related; Lymphoma, Hodgkins; Malignant Lymphomas; Metastatic Breast Cancer; Multiple Myeloma (MM); Mycosis Fungoides (MF); Neuroblastomas; Ovarian Cancer Metastatic; Ovarian Carcinoma; Sarcoma, Bone; Sezary Syndrome; Soft Tissue Sarcoma (STS); Thyroid Carcinoma; Waldenstrom's Macroglobulinemia (WM); Wilms' tumor; Advanced Thymoma; Advanced uterine sarcoma TOP2A; ATRX; AFP; ZEB1; MYB; NOS3; NCF4; RPSA; LRP1B; CYBA; GADD45A; PPM1D; EZH2; QUINONE REDUCTASE 2; TAF1; RAC2; SLC28A3; AKR1A1; SLC22A16; MYOD1; EDN1; GSTA1; CBR3; SDHB; LINC00251; H2AX; DOK5; ALDH3A1; GATA3; AKR1C3; CDKN1B; AKR7A2; IL11; CBR1; SP3; SETD4; BMP7 22/06/2022
Durvalumab Y Y N N 2017 N DB11714 L01FF03 CHEMBL3301587 Unresectable Stage III Non-small Cell Lung Cancer; Urothelial carcinoma ureter metastatic; Locally advanced Urothelial Carcinoma; Unresectable, locally advanced PD-L1 positive Lung Cancer Non-Small Cell Cancer (NSCLC) CD274; MSH2; PBRM1; EGFR; MSH6; ALK 01/02/2022
Duvelisib Y Y N N 2018 N DB11952 L01EM04 CHEMBL3039502 Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL); Relapsed or Refractory Follicular Lymphoma; Refractory, relapsed small lymphocytic lymphoma PIK3CD; PIK3CG 22/06/2022
Edotreotide Y N N N 2019 N DB15494 V09IX09 CHEMBL408350 Neuroendocrine Tumors 22/06/2022
Elotuzumab Y Y N N 2015 N DB06317 L01FX08 CHEMBL1743010 Refractory Multiple Myeloma SLAMF7 01/02/2022
Emapalumab N Y N N 2018 N DB14724 L04AA39 CHEMBL3989977 IFNG; SH2D1A; RAB27A; PRF1; UNC13D; XIAP; STX11; STXBP2 17/09/2020
Enasidenib N Y N N 2017 N DB13874 L01XX59 CHEMBL3989908 Refractory Acute Myelogenous Leukemia (AML); Relapsed Acute Myelogenous Leukemia (AML) IDH2; FLT3 17/09/2020
Encorafenib Y Y N N 2018 N DB11718 L01EC03 CHEMBL3301612 Metastatic Melanoma; Unresectable Melanoma ARAF; RAF1; BRAF; PTEN; KRAS; MAP2K1 01/02/2022
Enfortumab Vedotin Y Y N N 2021 N DB13007 L01FX13 CHEMBL3301589 Locally Advanced Urothelial Cancer, Metastatic Urothelial Cancer NECTIN4 01/02/2022
Entrectinib Y Y N N 2019 N DB11986 L01EX14 CHEMBL1983268 Metastatic Solid Tumors; Non-Small Cell Lung Carcinoma (NSCLC); Tumors, Solid NTRK3; NTRK2; ROS1; NTRK1; EML4; NPM1; CAMK1D; ETV6; GRK5; TBK1; ALK 01/02/2022
Enzalutamide Y Y N N 2012 N DB08899 L02BB04 CHEMBL1082407 Metastatic Castration Resistant Prostate Cancer AR; PTEN 01/02/2022
Epirubicin N Y Y N 1999 Y DB00445 L01DB03 CHEMBL417 Breast Cancer; Breast Cancer Stage II; Breast Cancer Stage III; Colorectal Cancers; Hormone Refractory Prostate Cancer; Non-Small Cell Lung Carcinoma (NSCLC); Ovarian Cancer; Papillary transitional cell carcinoma of bladder; Recurrent Superficial Bladder Cancer; Small Cell Lung Cancer (SCLC); Soft Tissue Sarcoma (STS); Stomach Tumor; Carcinoma in situ of urinary bladder TOP2A; CHD1; GSTP1; PON1; IRS1; MDM4; PERP; GNL3; BIRC5; CYP1B1; BCL2; CBR3; TP53AIP1; CCNK; PPP2R5D; HMMR; SERPINE1; NOS3; FOXO1; RBX1; FOXP3 01/02/2022
Erdafitinib N Y N N 2019 N DB12147 L01EN01 CHEMBL3545376 Locally Advanced, Susceptible FGFR3 or FGFR2 genetic alterations, Condition has progressed during or following at least one line of prior platinum- containing chemotherapy including within 12 months of neoadjuvant or adjuvant platinum-containing chemotherapy urothelial carcinoma; Metastatic Susceptible FGFR3 or FGFR2 genetic alterations, Condition has progressed during or following at least one line of prior platinum- containing chemotherapy including within 12 months of neoadjuvant or adjuvant platinum-containing chemotherapy Metastatic Urothelial Carcinoma FGFR2; FGFR1; FGFR3; KRAS; EGFR 22/06/2022
Eribulin Y Y N N 2010 N DB08871 L01XX41 CHEMBL1683590 Metastatic Liposarcoma; Refractory, metastatic Breast cancer; Unresectable Liposarcoma ERBB2; TUB; ESR2; PGR; CDK2; ESR1 22/06/2022
Erlotinib Y Y N Y 2004 Y DB00530 L01EB02 CHEMBL553 Locally Advanced Non-Small Cell Lung Cancer; Locally Advanced Pancreatic Cancer; Metastatic Non-Small Cell Lung Cancer; Non-Small Cell Lung Carcinoma (NSCLC); Pancreatic Cancer Metastatic EGFR; ERBB4; CDH1; DDR2; KRAS; FGFR4; MAP3K1; NRG1; APC; CBL; ERRFI1 14/11/2022
Estramustine N Y Y N 1981 N DB01196 L01XX11 CHEMBL1575 Metastatic Hormone Refractory Prostate Cancer BAX; KLK3; BCL2; HEXB 28/10/2021
Etoposide N Y Y Y 1983 Y DB00773 L01CB01 CHEMBL44657 Acute Lymphoblastic Leukaemias (ALL); Acute Myeloid Leukemia (AML); Advanced Hodgkin's Lymphoma; Ewing's Sarcoma; Merkel cell cancer; Multiple Myeloma (MM); Neuroblastomas; Neuroendocrine Tumours; Non-Hodgkin's Lymphoma (NHL); Non-Small Cell Lung Carcinoma (NSCLC); Ovarian Cancer; Prostate Cancer; Retinoblastoma; Sarcoma, Osteogenic; Small Cell Lung Cancer (SCLC); Wilms' tumor; Locally advanced Thymoma; Metastatic Thymic Cancer; Refractory Sarcoma; Refractory Testicular cancer TOP2A; TOP2B; SLIT1; PAPOLA; EIF4E; TNFSF13B; MUC16; ITGAL; IGF2; GDF15; NCOA1; NCOA3; BTF3P11; ERCC2; DYNC2H1; PLA2G6; MYCN; GSTT1; ACTR2; UGT1A10; KLK3; AFP; E2F1; UGT1A1; BRCA2; PGP; PLA2G1B 01/02/2022
Everolimus Y Y N N 2009 Y DB01590 L04AA18; L01EG02 CHEMBL1908360 Subependymal giant cell astrocytoma, tuberous sclerosis complex; Advanced Carcinoid tumor; Locally advanced gastrointestinal origin Progressive Neuroendocrine Tumors; Locally advanced lung origin Progressive Neuroendocrine Tumors; Metastatic gastrointestinal origin Progressive Neuroendocrine Tumors; Metastatic lung origin Progressive Neuroendocrine Tumors; Pancreatic origin Progressive Neuroendocrine Tumors; Refractory Advanced Renal Cell Carcinoma; Refractory Waldenstrom's Macroglobulinaemia; Refractory, advanced Breast cancer; Unresectable gastrointestinal origin Progressive Neuroendocrine Tumors; Unresectable lung origin Progressive Neuroendocrine Tumors MTOR; FKBP1A; GNAQ; RPTOR; BRCA2; STK11; BRAF; RB1; NF2; HRAS; BAP1; KDM5C; PTEN; NOTCH1; NRAS; FLCN; VHL; PIK3CA; TSC2; TSC1; MPL; PBRM1; GNA11 14/11/2022
Exemestane N Y Y N 1999 Y DB00990 L02BG06 CHEMBL1200374 Early Breast Cancer; Refractory, advanced Breast cancer CYP19A1; AKR1C3; PGR; AKR1C4; KMT2C; MAP4K4; TUBB1; CYP1B1; BGLAP 14/11/2022
Fedratinib Y Y N N 2019 N DB12500 L01EJ02 CHEMBL1287853 JAK2; FLT3 22/06/2022
Fludarabine N Y Y Y 1991 Y DB01073 L01BB05 CHEMBL1568 B-cell chronic lymphocytic leukemia/prolymphocytic leukemia/small lymphocytic lymphoma refractory; Refractory Non-Hodgkin's lymphoma RRM1; POLA1; DCK; IKZF1; ATM; SULT2B1; CXCL12; SLC22A12; SLC29A1; ADA; MPO; SLCO1B1; CD40; BAX; XIAP; CYP2E1 22/06/2022
Fluorouracil N Y Y Y 1962 Y DB00544 L01BC02 CHEMBL185 Breast Cancer; Malignant Neoplasm of Colon; Malignant Neoplasm of Pancreas; Malignant Neoplasm of Stomach; Rectal Carcinoma; Superficial Basal Cell Carcinoma TYMS; ABCC11; GNL3; GALNT14; SELE; KLC1; IL11; PERP; ENOSF1; SHMT1; HLA-G; TYMP; ALCAM; IL6R; ABCC5; TP53AIP1; CBLB; IGFBP3; SMAD4; PPP2R5D; SLC19A1; SLC22A16; PTPRC; XRCC1; XRCC3; DLG5; EXO1; DPYS; DPYD; ABCG1; CYP2A6; TSHB; RGS5; TPT1; RBX1; PARD3B; NT5C1A; MYB; ALDH3A1; WNT5B; REV3L; XRCC4; MUC2; ERCC1; CDKN1A; MTHFR; MIR27A; NOS3; CCNK; CDC25C; PON1; DKK1; LGR5; CBR1; FPGS; UMPS; DTYMK; TMEM167A; CHN2; MEGF11; FOXO1; CBR3; HMMR; NQO1 14/11/2022
Fluoxymesterone N Y N N 1956 Y DB01185 G03BA01 CHEMBL1445 Inoperable, metastatic Breast cancer AR; NR3C1; PRL 17/09/2020
Flutamide N Y Y N 1989 Y DB00499 L02BB01 CHEMBL806 C Prostatic Carcinoma; Stage B2 Prostatic Carcinoma; Stage D2 Prostatic carcinoma BIRC5; TH; PEBP1; CDKN1A; IL2RA; AQP9; VIP; KLK3; MPO 01/02/2022
Fotemustine Y N N N DB04106 L01AD05 CHEMBL549386 Metastatic Melanoma TXNRD1; MGMT 17/09/2020
Fulvestrant Y Y N N 2002 Y DB00947 L02BA03 CHEMBL1358 Advanced or Metastatic Breast Cancer; Refractory, advanced Breast cancer; Refractory, metastatic Breast cancer ESR1; ESR2; FGFR2; TFPI; PGR; CDK6; PIK3CA; CCNE1; PTEN; EPHX2; ESRRA 14/11/2022
Futibatinib N Y N N 2022 DB15149 L01EN04 CHEMBL3701238 Locally Advanced Intrahepatic Cholangiocarcinoma, Metastatic Intrahepatic Cholangiocarcinoma, Unresectable Intrahepatic Cholangiocarcinoma 14/11/2022
Gefitinib Y Y N Y 2003 Y DB00317 L01EB01 CHEMBL939 Metastatic Non-Small Cell Lung Cancer EGFR; ERBB3; IKBKE; SIRT2; NFKBIB; MAP3K1; CRKL; SIK2; CEACAM5; PBK; TAB2; EMP1; SMO; IGF2; NR1H2; NFKBIA 22/06/2022
Gemcitabine N Y Y Y 1996 Y DB00441 L01BC05 CHEMBL888 Advanced Ovarian Cancer; Bladder Transitional Cell Carcinoma Stage IV; Cervical Cancers; Cutaneous T-Cell Lymphoma (CTCL); Head and Neck Carcinoma; Hodgkins Disease (HD); Locally Advanced Pancreatic Adenocarcinoma; Mesothelioma; Metastatic Breast Cancer; Non-Small Cell Lung Cancer Stage IIIB; Non-small Cell Lung Cancer (NSCLC), Stage IV; Non-small Cell Lung Cancer Stage IIIA; Small Cell Lung Cancer (SCLC); Stage 4 Pancreatic adenocarcinoma CMPK1; RRM2; RRM1; CBL; HLA-C; SLC28A3; ATAT1; SLC28A1; POLR1G; SLC29A2; FKBP5; SMAD4; SLC29A1; NT5C1A; SLC29A3; CDA; SERPINA5; PRRC2A; XRCC1; SH2D5; GPX5; NT5C3A; IGF2; ATRX; CDSN; ALG10; WEE1; XYLT2; DCTD; MSH5; PPCDC; NT5C; PPP1R13L; CDC5L; ETS2; PPP1R18; CIP2A; ACSS2; ERCC1; DOCK8; SLC28A2; TENT4A; DCK; MUCL3; KLC3; DAPK1; C6ORF15; POLR2A; PSORS1C1; FANCC; FHL2; NT5C2; HCP5 01/02/2022
Gemtuzumab Ozogamicin Y Y N N 2000 N DB00056 L01FX02 CHEMBL1201506 Acute Myeloid Leukemia (AML); Refractory Acute Myelogenous Leukemia (AML); Relapsed Acute Myelogenous Leukemia (AML) ABCB1; CD33 01/02/2022
Gilteritinib Y Y N N 2018 N DB12141 L01EX13 CHEMBL3301622 Relapsed or Refractory Acute Myeloid Leukemia With FLT3 Activating Mutations AXL; FLT3 22/06/2022
Glasdegib Y Y N N 2018 N DB11978 L01XJ03 CHEMBL2043437 Acute Myeloid Leukemia (AML) SMO; MTOR 17/09/2020
Goserelin N Y Y N 1989 N DB00014 L02AE03 CHEMBL1201247 Advanced Breast Cancer; Early Breast Cancer; Advanced carcinoma of the prostate; Stage M1 hormone dependent carcinoma of the prostate; Stage T2b carcinoma of the prostate; Stage T2c carcinoma of the prostate; Stage T3 carcinoma of the prostate; Stage T4 carcinoma of the prostate LHCGR; ESR2; MYOD1; PGR; GNRH1; ESR1 22/06/2022
Histamine dihydrochloride Y Y N N 1939 N DB05381 L03AX14 CHEMBL90 HRH4; HRH2; SLC29A4; LMNA 22/06/2022
Histrelin N Y N N 1991 N DB06788 L02AE05 CHEMBL1201255 Advanced Prostate Cancer GNRHR; GNRHR2 22/09/2020
Hydroxycarbamide N Y N Y 1967 Y DB01005 L01XX05 CHEMBL467 Essential Thrombocythemia (ET); Head and Neck Carcinoma; Melanomas; Ovarian Cancer Metastatic; Polycythemia Vera (PV); Chronic, refractory Myeloid Leukemia; Inoperable Ovarian cancer RRM2; RRM1; RRM2B; CP; DNTT; MAP3K5; DUSP1; EIF4E; PTH; ABL1; DNMT1; HRAS 14/11/2022
Ibritumomab Tiuxetan Y Y N N 2002 N DB00078 V10XX02 CHEMBL1201606 Follicular Non-Hodgkin's Lymphoma; Follicular Non-Hodgkin's Lymphoma Refractory MS4A1 17/09/2020
Ibrutinib Y Y N N 2013 N DB09053 L01EL01 CHEMBL1873475 Chronic Lymphocytic Leukaemia (CLL); Mantle Cell Lymphoma (MCL); Waldenstrom's Macroglobulinemia (WM) BTK; ERBB2; BMX; LYN; PLCG2; MYD88; ATM; MYC 22/06/2022
Idarubicin N Y Y N 1990 Y DB01177 L01DB06 CHEMBL1117 Acute Myeloid Leukemia (AML) TOP2A; NT5C3A; ETV6; RAC2; CYP2E1; SLC22A12; SULT2B1; NCF4; DNMT3A; DCK; CYBA 01/02/2022
Idecabtagene Vicleucel Y Y N N 2021 N DB16665 L01XL07 CHEMBL4298199 Refractory Multiple Myeloma, Relapsed Multiple Myeloma TNFRSF17 23/10/2022
Idelalisib Y Y N N 2014 N DB09054 L01EM01 CHEMBL2216870 Relapsed Chronic Lymphocytic Leukemia; Relapsed Small Lymphocytic Lymphoma; Relapsed follicular B-cell non-Hodgkin lymphoma PIK3CA; PIK3CD; BRAF; PTEN 22/06/2022
Ifosfamide N Y Y Y 1988 Y DB01181 L01AA06 CHEMBL1024 Cancer, Bladder; Cervical Cancers; Ewing's Sarcoma; Head and Neck Carcinoma; Lymphoma, Hodgkins; Malignant Neoplasm of Pancreas; Non-Hodgkin's Lymphoma (NHL); Ovarian Cancer; Sarcoma, Osteogenic; Small Cell Lung Cancer (SCLC); Soft Tissue Sarcoma (STS); Testicular Germ Cell Cancer; Advanced thymic carcinoma IL6; DNMT1; CYP2A6; GSTP1; HSPA4; NR1I2; MGMT; CYP2B6 01/02/2022
Imatinib Y Y N Y 2001 Y DB00619 L01EA01 CHEMBL941 Chordomas; Chronic Eosinophilic Leukemia (CEL); Chronic Myeloid Leukemia (CML); Desmoid Tumors; FIP1L1-PDGFRa fusion kinase status unknown Chronic eosinophilic leukemia; Metastatic Gastrointestinal Stromal Tumor; Metastatic Melanoma; Myelodysplastic Syndromes (MDS); Refractory Acute Lymphoblastic Leukemia; Metastatic Dermatofibrosarcoma protuberans; Newly diagnosed Acute Lymphoblastic Leukaemia; Newly diagnosed, chronic phase Chronic myeloid leukemia; Recurrent Dermatofibrosarcoma protuberans; Refractory, accelerated phase Chronic myeloid leukemia; Refractory, blast crisis Chronic myeloid leukemia; Refractory, chronic phase Chronic myeloid leukemia; Systemic mastocytosis with associated hematological neoplasm; Unresectable Gastrointestinal stromal tumor ABL1; PDGFRB; KIT; PDGFRA; BCR; DDR1; NTRK1; CSF1R; SLC19A1; ETV6; ABCB4; PDGFB; CD40LG; ULK3; CHST1; CYP2F1; CTNNB1; SLC22A5; ABCG2; BCL2L11; SLC22A4; SLCO1A2; UGT2A1; GSTT1; XIAP; RCSD1; ABL2; FIP1L1; QUINONE REDUCTASE 2; IKZF1; SFN; SMAD4; SLC22A1 14/11/2022
Imiquimod Y Y N N 1997 Y DB00724 D06BB10 CHEMBL1282 Superficial Basal Cell Carcinoma TLR7; IFNA1 17/09/2020
Infigratinib N Y N N 2021 N DB11886 L01EN03 CHEMBL1852688 Unresectable, locally advanced Cholangiocarcinomas, Unresectable, metastatic Cholangiocarcinomas PIK3C2G; FGFR2; FGFR1; FGFR4; FGFR3; PIK3C2B; PIK3C2A; PIK3R4; PIK3R6; PIK3C3 01/02/2022
Inotuzumab Ozogamicin Y Y N N 2017 N DB05889 L01FB01 CHEMBL2108611 Refractory B-cell precursor acute lymphoblastic leukemia; Relapsed B cell precursor Acute lymphoblastic leukemia CD22 01/02/2022
Interferon Alfa-2b Y Y N N 1986 N DB00105 L03AB05 CHEMBL1201558 Hairy Cell Leukemia (HCL); Kaposi's sarcoma; Melanoma, Malignant IFNAR1; IFNAR2 17/09/2020
Iobenguane N Y N N 1994 N DB06704 V09IX01; V09IX02; V10XA02 CHEMBL818 Metastatic Pheochromocytoma; Metastatic Neuroblastoma; Primary Neuroblastomas; Primary Pheochromocytomas; Unresectable, locally advanced iobenguane-scan positive Paraganglioma; Unresectable, locally advanced iobenguane-scan positive Pheochromocytomas; Unresectable, metastatic iobenguane-scan positive Paraganglioma; Unresectable, metastatic iobenguane-scan positive Pheochromocytomas TH; SLC6A2 17/09/2020
Ipilimumab Y Y N N 2011 N DB06186 L01FX04 CHEMBL1789844 Advanced Renal Cell Carcinoma; Cutaneous Melanoma; Hepatocellular Carcinoma; Metastatic Melanoma; Unresectable Melanoma; Metastatic MSI-H/dMMR colorectal cancer CTLA4; PBRM1; MDM2; HLA-A; NRAS 01/02/2022
Irinotecan N Y Y Y 1996 Y DB00762 L01CE02 CHEMBL481 Esophageal Cancers; Ewing's Sarcoma; Glioblastomas; Malignant Neoplasm of Pancreas; Malignant Neoplasm of Stomach; Metastatic Colorectal Carcinoma; Non-Small Cell Lung Carcinoma (NSCLC); Ovarian Cancer; Rhabdomyosarcomas; Small Cell Lung Cancer (SCLC); Recurrent, IV-B Cervical cancer; Recurrent, metastatic Colorectal carcinoma; Refractory, metastatic Pancreatic adenocarcinoma TOP1; TOP1MT; ISG15; ABCC5; UGT1A9; XRCC3; KRAS; C8ORF34; CES2; BRAF; TGFBR2; ABCG1; RAD50; RUNX3; BCHE; CES1; ATRX; AREG; E2F1; TYMS; SEMA3C; KLC1; SHMT1; UGT1A; SLC19A1; UBE2I; SMAD4; KCNQ5; DPYD; DCBLD1; RGS5; DKK1 14/11/2022
Irinotecan Liposome Y Y N N 1996 Y DB00762 L01XX19 CHEMBL481 Esophageal Cancers; Ewing's Sarcoma; Glioblastomas; Malignant Neoplasm of Pancreas; Malignant Neoplasm of Stomach; Metastatic Colorectal Carcinoma; Non-Small Cell Lung Carcinoma (NSCLC); Ovarian Cancer; Rhabdomyosarcomas; Small Cell Lung Cancer (SCLC); Recurrent, IV-B Cervical cancer; Recurrent, metastatic Colorectal carcinoma; Refractory, metastatic Pancreatic adenocarcinoma TOP1; TOP1MT; ISG15; ABCC5; UGT1A9; XRCC3; KRAS; C8ORF34; CES2; BRAF; TGFBR2; ABCG1; RAD50; RUNX3; BCHE; CES1; ATRX; AREG; E2F1; TYMS; SEMA3C; KLC1; SHMT1; UGT1A; SLC19A1; UBE2I; SMAD4; KCNQ5; DPYD; DCBLD1; RGS5; DKK1 14/11/2022
Isatuximab Y Y N N 2020 N DB14811 L01FC02 CHEMBL3545131 Multiple Myeloma (MM) CD38 01/02/2022
Ivosidenib N Y N N 2018 N DB14568 L01XX62 CHEMBL3989958 Refractory, relapsed Acute Myeloid Leukemia IDH1 17/09/2020
Ixabepilone N Y N N 2007 N DB04845 L01DC04 CHEMBL1201752 Locally Advanced Breast Cancer (LABC); Metastatic Breast Cancer TUBB1; TUBB2A; TUBB3; PGR; TUB 22/06/2022
Ixazomib Y Y N N 2015 N DB09570 L01XG03 CHEMBL2141296 Multiple Myeloma (MM) PSMC5; NPM1 22/06/2022
Lanreotide N Y Y N 2007 N DB06791 H01CB03 CHEMBL1201185 Unresectable, locally advanced enteropancreatic neuroendocrine tumors; Unresectable, locally advanced gastroenteropancreatic neuroendocrine tumors; Unresectable, metastatic enteropancreatic neuroendocrine tumors; Unresectable, metastatic gastroenteropancreatic neuroendocrine tumors SSTR5; SSTR1; EDN1 22/06/2022
Lapatinib Y Y N N 2007 Y DB01259 L01EH01 CHEMBL554 Metastatic Breast Cancer; Refractory, advanced Breast cancer; Refractory, metastatic Breast cancer EGFR; ERBB2; ERBB4; ABCB11; CCND1; CDH1; EEF2K; HLA-DRB1; NRG1; CDKN1B; ERBB3; HLA-DQA1; PIK3CA; BIRC5 01/02/2022
Larotrectinib Y Y N N 2018 N DB14723 L01EX12 CHEMBL3889654 NTRK1 Fusion Positive; NTRK2 Fusion Positive; NTRK3 Fusion Positive NTRK3; NTRK2; NTRK1; ETV6 17/09/2020
Lenalidomide Y Y N Y 2005 Y DB00480 L04AX04 CHEMBL848 Chronic Lymphocytic Leukemia (CLL) - Refractory; Follicular Lymphoma (FL); Mantle Cell Lymphoma (MCL); Marginal Zone Lymphoma (MZL); Multiple Myeloma (MM); Myelodysplastic Syndrome; Refractory Diffuse Large B Cell Lymphoma CUL4A; TNFSF11; CRBN; DDB1; RBX1; CTNNB1; TNF; IKZF1; FGF2; VEGFB; VEGFC; VEGFA 14/11/2022
Lenvatinib Y Y N N 2015 N DB09078 L01EX08 CHEMBL1289601 Advanced Renal Cell Carcinoma; Locally recurrent radioactive iodine-refractory Thyroid cancer; Metastatic radioactive iodine-refractory Thyroid cancer; Progressive radioactive iodine-refractory Thyroid cancer FLT4; FGFR2; RET; FLT1; KIT; KDR; FGFR1; PDGFRA; NRAS; BRAF 01/02/2022
Letrozole N Y Y N 1997 Y DB01006 L02BG04 CHEMBL1444 Advanced Breast Cancer; Early Breast Cancer; Ovarian Epithelial Cancer; Advanced HR + HER2 - breast cancer; Metastatic HR + HER2 - breast cancer CYP19A1; ESR2; MMP2; CDKN2A; PGR; CYP2A6; ESR1; CYP1B1; TNFRSF11B; KMT2C; TNFSF11 01/02/2022
Leuprolide N Y N N 1985 Y DB00007 L02AE51; L02AE02 CHEMBL1201199 Advanced Prostate Cancer GNRHR; GNRH1 17/09/2020
Lisocabtagene Maraleucel Y Y N N 2021 N DB16582 CHEMBL4297236 Grade 3b Follicular Lymphoma; High-grade B-cell Lymphoma (HGBCL); Primary mediastinal large B-cell lymphomas; Refractory Diffuse Large B Cell Lymphoma; Refractory Large B-cell Lymphoma; Relapsed Large B-cell Lymphoma; Relapsed, Diffuse Large B-cell Lymphoma CD19 31/01/2022
Lomustine N Y Y N 1976 N DB01206 L01AD02 CHEMBL514 Primary Brain Tumors; Refractory Hodgkin Lymphoma; Tumors Metastatic to Brain MGMT; ADK; ATRX 17/09/2020
Loncastuximab Tesirine Y Y N N 2021 N DB16222 L01FX22 CHEMBL4297778 Refractory Large B-cell Lymphoma, Relapsed Large B-cell Lymphoma 23/10/2022
Lorlatinib Y Y N N 2018 N DB12130 L01ED05 CHEMBL3286830 Progressive, metastatic Anaplastic lymphoma kinase-positive Metastatic Non-Small Cell Lung Cancer ROS1; ALK; EML4; NPM1; RB1 22/06/2022
Lu 177-Dotatate Y Y N N 2018 N DB13985 CHEMBL3989924 Gastroenteropancreatic Neuroendocrine Tumors 17/09/2020
Lurbinectedin N Y N N 2020 N DB12674 L01XX69 CHEMBL4297516 Metastatic Small Cell Lung Cancer 17/09/2020
Lutetium Lu 177 Vipivotide Tetraxetan Y Y N N 2022 N DB16778 V10XX05 Metastatic Castration Resistant Prostate Cancer (CRPC) 22/06/2022
Margetuximab N Y N N 2020 N DB14967 L01FD06 CHEMBL2364649 HER2-positive Metastatic Breast Cancer ERBB2; ERBB3 23/10/2022
Medroxyprogesterone N Y Y N 1959 Y DB00603 G03DA02; G03AC06; L02AB02 CHEMBL717 Metastatic Renal Cell Carcinoma; Metastatic Endometrial carcinoma PGR; MMP1; BAX; CYP1B1; ERG 14/11/2022
Megestrol N Y Y N 1971 Y DB00351 G03DB02; G03AC05; L02AB01 CHEMBL1201139 Advanced Breast Cancer; Advanced Endometrial Cancer PGR; NPSR1 14/11/2022
Melphalan N Y Y Y 1964 Y DB01042 L01AA03 CHEMBL852 Multiple Myeloma (MM); Ovarian Epithelial Cancer; Severe Hodgkin Lymphoma MGMT; PLAT; SLC7A5; ABCC1; CDKN1A; GSTP1; OPLAH; ABL1; FANCC; IFNG; CTLA4 14/11/2022
Melphalan Flufenamide Y Y N N 2021 N DB16627 L01AA10 CHEMBL4303060 Relapsed Or Refractory Multiple Myeloma 23/10/2022
Mercaptopurine Y Y N Y 1953 Y DB01033 L01BB02 CHEMBL1425; CHEMBL1200751 Acute Lymphoblastic Leukaemias (ALL); Acute Promyelocytic Leukemia (APL); Lymphoma, Lymphoblastic IMPDH1; HPRT1; PPAT; ITPA; NOTCH1; IL2RA; GATA3; HLA-DRB1; PACSIN2; GNMT; RB1; HLA-DQA1; NUDT15; TYMSOS; PRPS1; FTO; DROSHA; FOLH1; ABCC4; NT5C2; TPMT; SLC29A2; VCAM1; MTHFR 01/02/2022
Methotrexate Y Y N Y 1953 Y DB00563 L04AX03; L01BA01 CHEMBL34259 Acute Lymphocytic Leukemia (ALL); Acute Promyelocytic Leukemia (APL); Breast Cancer; Cancer, Bladder; Central Nervous System Lymphoma; Choriocarcinoma; Head and Neck Carcinoma; Meningeal leukemia; Sarcoma, Osteogenic; Small Cell Lung Cancer (SCLC); Soft Tissue Sarcoma (STS); Squamous Cell Carcinoma of Lung; Advanced Alibert-Bazin syndrome; Advanced non-Hodgkin lymphoma; Nonleukemic meningeal cancer DHFR; ATIC; HLA-E; UGT1A10; FOLR1; UGT1A7; IL1RN; ABCC2; SULT2A1; HGF; CCND1; MTRR; ATP5F1E; FOXP3; NALCN; BMP7; S100A8; TAT; SLC46A1; ABCC4; SLC22A11; IKZF1; SPECC1L; TPM3; PYGL; UGT1A8; HLA-G; FPGS; SOD2; DROSHA; PACSIN2; UGT1A5; KIR2DS4; SLC16A7; ITPA; SLCO1B1; CDKN1B; SLC22A8; ADORA2A-AS1; SLC22A9; SLCO1A2; SHMT1; AFP; HLA-C; ADA; ENOSF1; LINC00251; ARID5B; S100A12; GGH; KLRD1; TLR4; KCNA1; TNFAIP3; HSPB2; PTPRM; FOLH1; SLAMF1; AMPD1; DOK5; ICAM3; NOS3 14/11/2022
Midostaurin Y Y N N 2017 N DB06595 L01EX10 CHEMBL608533 Acute Myeloid Leukemia (AML); Malignant mast cell neoplasm; Systemic mastocytosis with associated hematological neoplasm KIT; PRKCA; PRKCZ; PRKCE; PRKCI; PRKCB; PDGFRA; PRKCQ; PRKCH; PRKD1; FLT3; PRKCG; HSPA4; ETV6; NPM1; STK32B; PIK3CB 22/06/2022
Mifamurtide Y N N N 2009 N DB13615 L03AX15 CHEMBL2111100; CHEMBL2107354 High-grade, nonmetastatic Osteosarcoma; Resectable, nonmetastatic Osteosarcoma NOD2 17/09/2020
Mitomycin N Y Y N 1981 Y DB00305 L01DC03 CHEMBL105 Adenocarcinoma of the Pancreas; Adenocarcinoma of the Stomach; Breast Cancer; Cancer, Anal; Cancer, Bladder; Cervical Cancers; Head and Neck Carcinoma; Mesothelioma; Non-Small Cell Lung Carcinoma (NSCLC); Low-grade Upper Tract Urothelial Cancer (LG-UTUC) BGLAP; PALB2; FANCC; VWF 14/11/2022
Mitoxantrone N Y Y N 1987 Y DB01204 L01DB07 CHEMBL58 Acute Lymphocytic Leukemia (ALL); Acute Myeloid Leukemia (AML); Acute Promyelocytic Leukemia (APL); Lymphoma, Hodgkins; Metastatic Breast Cancer; Non-Hodgkin's Lymphoma (NHL); Relapsed Leukemia; Relapsed Lymphomas; Hormone refractory, advanced Prostate cancer; Relapsed Hepatocellular carcinoma TOP2A; UGT1A5; MBNL1; C10ORF67; GALNT14; PIM1; RPSA; DNMT1 22/06/2022
Mobocertinib N Y N N 2021 N DB16390 L01EB10 CHEMBL4650319 Locally Advanced Non-Small Cell Lung Cancer, Metastatic Non-Small Cell Lung Cancer 23/10/2022
Mogamulizumab Y Y N N 2018 N DB12498 L01FX09 CHEMBL1743041 Refractory Mycosis Fungoides/Sezary Syndrome; Relapsed Mycosis Fungoides/Sezary Syndrome CCR4 01/02/2022
Mosunetuzumab Y N N N 2022 N DB15434 CHEMBL4297788 Relapsed follicular lymphoma, Refractory follicular lymphoma MS4A1 22/06/2022
Moxetumomab Pasudotox Y Y N N 2018 N DB12688 L01FB02 CHEMBL1743043 Relapsed/Refractory Hairy Cell Leukemia CD22 01/02/2022
Nab-Paclitaxel Y Y N N 2005 Y Not found in DrugBank L01CD01 CHEMBL428647 Advanced Cervical Cancer; Advanced Head and Neck Cancer; Advanced Ovarian Cancer; Advanced Soft Tissue Sarcoma; Esophageal Cancers; Fallopian Tube Cancer; Kaposi's sarcoma; Locally Advanced Non-Small Cell Lung Cancer; Malignant Neoplasm of Stomach; Malignant Peritoneal Neoplasm; Metastatic Bladder Cancer; Metastatic Breast Cancer; Metastatic Melanoma; Metastatic Non-Small Cell Lung Cancer; Non-Small Cell Lung Carcinoma (NSCLC); Ovarian Cancer; Pancreatic Adenocarcinoma Metastatic; Advanced Bladder cancer; Advanced Thymoma; Metastatic Penile cancer; Refractory Small cell lung cancer; Refractory Testicular germ cell cancer TUBB; TUBB8; TUBA4A; TUBA3E; TUBB2A; TUBA1A; TUBB1; TUBB3; TUBA3D; TUBB2B; TUBA1C; TUBA1B; BCL2; TUBB4B; TUBB6; ACSS2; STMN1; MAP3K1; FNTB; ERCC2; FGD4; PDCD4; DSCAM; EPHA5; EIF4EBP1; MYB; SLC29A1; GSTT1; TUBB4A; PGP; SOD2; SLCO1B3; TUBA3C; LIF; TLE3; SMAD4; SPATA5; NFE2; MAD1L1; EDNRB; SOX10; TRIM5; ABCC10; FOS; ERCC1 22/06/2022
Naxitamab N Y N N 2020 N DB15965 L01FX21 CHEMBL4297984 High risk, refractory Neuroblastomas of the bone or bone marrow; High risk, relapsed Neuroblastomas of the bone or bone marrow 23/10/2022
Necitumumab Y Y N N 2015 N DB09559 L01FE03 CHEMBL1743047 Metastatic Non-Small Cell Lung Cancer EGFR; KRAS 01/02/2022
Nelarabine Y Y N N 2005 Y DB01280 L01BB07 CHEMBL1201112 Lymphoblastic lymphoma (Precursor T-lymphoblastic lymphoma/leukemia) refractory; Refractory Acute Lymphoblastic Leukemia POLA1 14/11/2022
Neratinib Y Y N N 2017 N DB11828 L01EH02 CHEMBL180022 Breast Cancer EGFR; ERBB2; PIK3CA; BRAF; HERC2; PGR; KRAS 01/02/2022
Nilotinib Y Y N Y 2007 N DB04868 L01EA03 CHEMBL255863 Chronic Phase Chronic Myeloid Leukemia; Refractory Gastrointestinal stromal tumor; Refractory, accelerated phase Chronic myeloid leukemia ABL1; KIT; PDGFRA; PDGFRB; DDR2; LYN; BCR; UGT1A1; ABCG2; FLT3 22/06/2022
Nilutamide N Y N N 1996 Y DB00665 L02BB02 CHEMBL1274 Metastatic Hormone Refractory Prostate Cancer AR; KLK3 01/02/2022
Nintedanib Y Y N N 2014 N DB09079 L01EX09 CHEMBL502835 Locally advanced Non-Small Cell Lung Cancer (NSCLC) caused by Adenocarcinoma; Locally recurrent Non-Small Cell Lung Cancer (NSCLC) caused by Adenocarcinoma; Metastatic Non-Small Cell Lung Cancer (NSCLC) caused by Adenocarcinoma FRK; LYN; SRC; FLT4; FGFR2; FGR; PDGFRA; FLT1; PDGFRB; FGFR3; HCK; FGFR1; KDR; LCK; FLT3; FGFR4; CFLAR 22/06/2022
Niraparib Y Y N N 2017 N DB11793 L01XK02 CHEMBL1094636 Fallopian Tube Cancer; Ovarian Epithelial Cancer; Primary Peritoneal Cancer PARP1; PARP2; BRCA1; SLFN11; BRCA2; ATR; ATM 01/02/2022
Nivolumab Y Y N Y 2015 N DB09035 L01FF01 CHEMBL2108738 Advanced Renal Cell Cancer; Classical Hodgkin's Lymphoma; Hepatocellular Carcinoma; Low Risk Advanced Renal Cell Cancer; Melanomas; Metastatic Colorectal Cancer (MCRC); Metastatic Melanoma; Metastatic Non-Small Cell Lung Cancer; Metastatic Small Cell Lung Cancer; Metastatic Squamous Cell Carcinoma of the Head and Neck; Metastatic Urothelial Carcinoma (UC); Recurrent Head and Neck Squamous Cell Carcinoma; Unresectable Melanoma; Intermediate risk Advanced Renal Cell Cancer; Locally advanced Urothelial Carcinoma PDCD1; STK11; ARID1A; MDM2; PTEN; HLA-DRA; MDM4; PMS2; CDK12; PBRM1; EGFR; ALK; CD274 01/02/2022
Obinutuzumab Y Y N N 2013 N DB08935 L01FA03 CHEMBL1743048 Refractory Follicular Lymphoma; Previously untreated Chronic lymphocytic leukemia MS4A1 01/02/2022
Ofatumumab Y Y N N 2009 N DB06650 L04AA52; L01FA02 CHEMBL1201836 Chronic Lymphocytic Leukaemia (CLL); Chronic Lymphocytic Leukemia (CLL) - Refractory; Progressive Chronic Lymphocytic Leukaemia (CLL); Recurrent Chronic Lymphocytic Leukaemia (CLL) MS4A1 01/02/2022
Olaparib Y Y N N 2014 N DB09074 L01XK01 CHEMBL521686 Fallopian Tube Cancer; Malignant Peritoneal Neoplasm; Metastatic Breast Cancer; Ovarian Epithelial Cancer; Primary Peritoneal Cancer; Advanced deleterious germline or somatic BRCA-mutated advanced epithelial ovarian cancer; Advanced deleterious germline or somatic BRCA-mutated fallopian tube cancer; Advanced deleterious germline or somatic BRCA-mutated peritoneal cancer; Refractory Advanced Ovarian Cancer PARP2; PARP3; PARP1; IDH2; ATR; BARD1; CBLC; BRCA2; BAP1; CHEK1; VHL; STAG2; BRCA1; CDK12; PALB2; ATM; MYC 01/02/2022
Olaratumab Y Y N N 2016 N DB06043 L01FX10 CHEMBL1743049 Soft Tissue Sarcoma (STS) PDGFRA 01/02/2022
Omacetaxine Mepesuccinate N Y N N 2009 N DB04865 L01XX40 CHEMBL46286 Refractory, accelerated phase Chronic myeloid leukemia; Refractory, chronic phase Chronic myeloid leukemia TERT; ABL1; BCR; BIRC5 17/09/2020
Osimertinib Y Y N N 2015 N DB09330 L01EB04 CHEMBL3353410 Metastatic Non-Small Cell Lung Cancer EGFR; ERBB2; MET; KRAS; NRAS 17/09/2020
Oxaliplatin N Y Y Y 2002 Y DB00526 L01XA03 CHEMBL414804 Advanced Colorectal Cancer; Advanced Ovarian Cancer; Advanced Pancreatic Cancer; Chronic Lymphocytic Leukemia (CLL) - Refractory; Colon Cancer Stage III; Esophageal Cancers; Malignant Neoplasm of Stomach; Advanced biliary adenocarcinoma; Refractory Neuroendocrine Tumour; Refractory Non-Hodgkin's lymphoma; Refractory Testicular cancer DPYD; GSTP1; BAX; NOS3; VEGFA; NQO1; ATP7B; ZEB1; CSMD1; DKK1; SELE; ABCC5; BCL2; ATP7A; KLC3; MT1A; CXCL10; MTHFR; MGAT4A; FOXC2; ERCC1; PON1; PARD3B; GNA13; ERCC2 01/02/2022
Paclitaxel Y Y N Y 1992 Y DB01229 L01CD01 CHEMBL428647 Advanced Cervical Cancer; Advanced Head and Neck Cancer; Advanced Ovarian Cancer; Advanced Soft Tissue Sarcoma; Esophageal Cancers; Fallopian Tube Cancer; Kaposi's sarcoma; Locally Advanced Non-Small Cell Lung Cancer; Malignant Neoplasm of Stomach; Malignant Peritoneal Neoplasm; Metastatic Bladder Cancer; Metastatic Breast Cancer; Metastatic Melanoma; Metastatic Non-Small Cell Lung Cancer; Non-Small Cell Lung Carcinoma (NSCLC); Ovarian Cancer; Pancreatic Adenocarcinoma Metastatic; Advanced Bladder cancer; Advanced Thymoma; Metastatic Penile cancer; Refractory Small cell lung cancer; Refractory Testicular germ cell cancer TUBB; TUBB8; TUBA4A; TUBA3E; TUBB2A; TUBA1A; TUBB1; TUBB3; TUBA3D; TUBB2B; TUBA1C; TUBA1B; BCL2; TUBB4B; TUBB6; ACSS2; STMN1; MAP3K1; FNTB; ERCC2; FGD4; PDCD4; DSCAM; EPHA5; EIF4EBP1; MYB; SLC29A1; GSTT1; TUBB4A; PGP; SOD2; SLCO1B3; TUBA3C; LIF; TLE3; SMAD4; SPATA5; NFE2; MAD1L1; EDNRB; SOX10; TRIM5; ABCC10; FOS; ERCC1 14/11/2022
Padeliporfin Y N N N 2017 N DB15575 L01XD07 CHEMBL4298112 Low-Risk Prostate Cancer of the one lobe only 17/09/2020
Palbociclib Y Y N N 2015 N DB09073 L01EF01 CHEMBL189963 Advanced Breast Cancer; Metastatic Breast Cancer; Refractory, advanced Breast cancer; Refractory, metastatic Breast cancer CDK6; CDK4; CCND1; DYRK1B; CDKN2A; SMARCA4; SMARCB1; CDKN2B; RB1; PRKX; CCNE1; CCND3 01/02/2022
Panitumumab Y Y N N 2006 N DB01269 L01FE02 CHEMBL1201827 Metastatic Colorectal Cancer (MCRC) EGFR; HRAS; NRG3; NRG2; HBEGF; TGFA; BTC; BRAF; EGF; KRAS; AREG; NRAS; MAP2K1; EREG; NRG1; CDKN2A 01/02/2022
Panobinostat Y Y N N 2015 N DB06603 L01XH03 CHEMBL483254 Refractory Multiple Myeloma HDAC8; HDAC7; HDAC1; HDAC6; HDAC2; HDAC5; HDAC9; HDAC4; HDAC3; HDAC10; HDAC11; MYCN; SMARCB1; KRAS; KMT2A; BAP1 01/02/2022
Pazopanib Y Y N N 2009 Y DB06589 L01EX03 CHEMBL477772 Advanced Renal Cell Carcinoma; Advanced Soft Tissue Sarcoma; Advanced Thyroid cancer PDGFRB; FLT4; PDGFRA; FLT1; KIT; KDR; FGFR3; NEK2; CYP2C8; FGFR2; HLA-B; UGT1A1 14/11/2022
Pegaspargase Y Y N Y 1994 N DB00059 L01XX24 CHEMBL2108546 Acute Lymphoblastic Leukaemias (ALL) LINC00251; GATA3; BMP7; DOK5 17/09/2020
Peginterferon Alfa-2b Y Y N N 2001 N DB00022 L03AB10 CHEMBL1201561 Melanomas IFNAR2; IFNAR1 17/09/2020
Pembrolizumab Y Y N Y 2014 N DB09037 L01FF02 CHEMBL3137343 Advanced Renal Cell Carcinoma; Cervical Cancers; Colorectal Cancers; Metastatic Melanoma; Metastatic Solid Tumors; Unresectable Melanoma; Urothelial carcinoma ureter metastatic; Locally advanced Urothelial Carcinoma; Locally advanced gastroesphageal juntion adenocarcinoma; Metastatic gastroesphageal juntion adenocarcinoma; Metastatic nonsquamous non-small cell lung cancer; Recurrent, metastatic Head and Neck Squamous Cell Carcinoma; Refractory, metastatic Non small cell lung cancer; Refractory, relapsed Hodgkin Lymphoma; Refractory, relapsed Mediastinal Large B-cell Lymphoma; Unresectable Solid Tumors PDCD1; PDCD1LG2; B2M; MDM2; CDK12; PBRM1; STK11; ARID1A; CD274; ALK; MDM4; POLE; HLA-DRA; EGFR; JAK1; JAK2; NRAS; BRAF; PTEN 01/02/2022
Pemetrexed Y Y N N 2004 Y DB00642 L01BA04 CHEMBL225072 Mesothelioma; Ovarian Cancer; Pleural Mesotheliomas; Urothelial carcinoma ureter metastatic; Locally advanced nonsquamous non-small cell lung cancer; Metastatic nonsquamous non-small cell lung cancer; Recurrent, IV-B Cervical cancer; Unresectable Thymoma DHFR; GART; TYMS; ATIC; FOLR3; SLC46A1; MTHFR; GGH; KRAS; ALK; SLC19A1 14/11/2022
Pemigatinib Y Y N N 2020 N DB15102 L01EN02 CHEMBL4297522 Unresectable, locally advanced Cholangiocarcinomas; Unresectable, metastatic Cholangiocarcinomas FGFR2; FGFR1; FGFR3 01/02/2022
Pentostatin N N Y N 1991 Y DB00552 L01XX08 CHEMBL1580 B-Lymphocytic, prolymphocytic leukemia (Kiel Classification) refractory; Chronic Lymphocytic Leukaemia (CLL); Hairy Cell Leukemia (HCL); Mycosis Fungoides (MF); Sezary Syndrome ADA; PRKAA1 22/09/2020
Pertuzumab Y Y N N 2012 N DB06366 L01FD02 CHEMBL2007641 Early Breast Cancer; Inflammatory Breast Cancer (IBC); Locally Advanced Breast Cancer (LABC); Metastatic Breast Cancer ERBB2; PGR; NRG1; ESR2; PIK3CA; BRAF; ERBB3 01/02/2022
Pertuzumab, Trastuzumab, Hyaluronidase Y Y N N 2020 L01XY02 28/10/2021
Pipobroman N N Y N 1966 DB00236 L01AX02 CHEMBL1585 22/09/2020
Pirarubicin N N N Japan N DB11616 L01DB08 CHEMBL2354444 KMT2A; GLS; ABCC1 01/02/2022
Pixantrone Y N N N 2012 N DB06193 L01DB11 CHEMBL167731 Non-Hodgkin's Lymphoma, Relapsed; Refractory Non-Hodgkin's lymphoma TOP2B 17/09/2020
Polatuzumab Vedotin Y Y N N 2019 N DB12240 L01FX14 CHEMBL3301582 Diffuse Large B-Cell Lymphoma (DLBCL) CD79B 01/02/2022
Polyestradiol Phosphate N N Y N 1957 DB09369 L02AA02 CHEMBL1201477 ESR1 22/09/2020
Pomalidomide Y Y N N 2013 N DB08910 L04AX06 CHEMBL43452 Refractory Multiple Myeloma CRBN; CUL4A; DDB1; RBX1 17/09/2020
Ponatinib Y Y N N 2012 N DB08901 L01EA05 CHEMBL1171837 Accelerated phase chronic myologenic leukemia; Acute Lymphoblastic Leukaemias (ALL); Chronic Phase Chronic Myeloid Leukemia; Blast phase Chronic myelocytic leukemia FGFR4; RET; FLT3; FGFR3; FGFR1; SRC; FGFR2; PDGFRA; BCR; ABL1; KIT; PDGFRB; ABI1; ABL2 22/06/2022
Porfimer Y Y N N 1995 N DB00707 L01XD01 CHEMBL1201481 Esophageal Cancers; Completely obstructive Non-small cell lung cancer; Microinvasive endobrachial Non-small cell lung cancer; Partially obstructive Non-small cell lung cancer 17/09/2020
Pralatrexate Y Y N N 2009 N DB06813 L01BA05 CHEMBL1201746 Cutaneous T-Cell Lymphoma (CTCL); Relapsed Peripheral T-Cell Lymphoma; Refractory Peripheral T-cell Lymphoma Unspecified DHFR; PDF; RFC1 17/09/2020
Pralsetinib Y Y N N 2020 N DB15822 L01EX23 CHEMBL4297597 Metastatic RET-fusion Non Small Cell Lung Cancer RET 22/06/2022
Prednisolone Y Y N Y 1955 Y DB00860 S03BA02; S02BA03; S01CB02; S01BA04; R01AD02; H02AB06; D07XA02; D07AA03; C05AA04; A07EA01 CHEMBL131 Hypercalcemia of Malignancy; Leukemia, Acute; Malignant Lymphomas; Mycosis Fungoides (MF) NR3C1; ANXA1; RB1; FCGR3B; TAT; PNPLA3; BAX; NOTCH1; TG; CD34; PLG; ALPP; LOH19CR1; FCGR3A; LCAT; DSE; BGLAP; TSPYL1; HMGB1 14/11/2022
Prednisone N Y Y N 1955 Y DB00635 H02AB07; A07EA03 CHEMBL635 Acute Lymphoblastic Leukaemias (ALL); Aggressive Lymphoma; Hypercalcemia of Malignancy; Leukemia, Acute; Leukemias; Malignant Lymphomas; Metastatic Castration Resistant Prostate Cancer; Mycosis Fungoides (MF) NR3C1; TPMT; ANXA1; PTPRC; VWF; TG; DROSHA; CTLA4; GSTM1; LINC00251; BMP7; MC2R; CALCA; TYMSOS; APOE; DOK5; ITGB2; IFNG; GATA3; GSTA1; MBP; CXCL12 14/11/2022
Procarbazine N Y Y Y 1969 N DB01168 L01XB01 CHEMBL1321 Non-Hodgkin's Lymphoma (NHL); Oligodendrogliomas; Primary Central Nervous System Lymphoma (PCNSL); Stage III Hodgkin's Disease; Stage IV Hodgkin's Disease BAX; CSF2; ATRX 17/09/2020
Racotumomab N N N Cuba, Argentina N DB13045 CHEMBL1743059 17/09/2020
Radium 223 Dichloride Y Y N N 2013 N DB08913 V10XX03 CHEMBL2107816 Castration resistant, metastatic Prostate cancer 17/09/2020
Raltitrexed N N Y Canada N 1996 N DB00293 L01BA03 CHEMBL225071 Advanced Colorectal Cancer; Pleural Mesotheliomas TYMS; ALB; CDKN1B; CDK2; DHFR; BCL2; SLC19A1 17/09/2020
Ramucirumab Y Y N N 2014 N DB05578 L01FG02 CHEMBL1743062 Advanced Gastric Cancer; Advanced gastro-esophageal junction adenocarcinoma; Refractory, metastatic Colorectal cancer; Refractory, metastatic Non small cell lung cancer KDR; PDGFRA; KRAS; EGFR; ERBB2; ALK 01/02/2022
Ranimustine N N N Japan N DB13832 L01AD07 CHEMBL2105348 22/09/2020
Realgar-Indigo Naturalis Formulation N N N China Y 2009 Not found in DrugBank L01XX27 Acute promyelocytic leukaemia 10/03/2021
Regorafenib Y Y N N 2012 N DB08896 L01EX05 CHEMBL1946170 Hepatocellular Carcinoma; Metastatic Colorectal Cancer (MCRC); Metastatic Gastrointestinal Stromal Tumor; Locally advanced Gastrointestinal stromal tumor; Unresectable Gastrointestinal stromal tumor RAF1; FLT1; BRAF; DDR2; PDGFRA; FLT4; PDGFRB; KRAS; KIT; RET; TEK; FRK; KDR; MAPK11; EPHA2; ARAF; VHL; FBXW7; APC; NRAS 01/02/2022
Relatlimab Nivolumab Y Y N N 2022 DB14851 L01XY03 CHEMBL3990044 Metastatic Melanoma, Unresectable Melanoma LAG3 14/11/2022
Relugolix Y Y N N 2020 N DB11853 L02BX04 CHEMBL1800159 Advanced Prostate Cancer GNRHR; LHCGR 31/01/2022
Ribociclib Y Y N N 2017 N DB11730 L01EF02 CHEMBL3545110 Advanced Breast Cancer; Metastatic Breast Cancer CDK6; CDK4; CCND2; NRAS; RB1; CCND1; CDKN2A; SMARCA4; CCND3; NOTCH1; PGR 01/02/2022
Ripretinib Y Y N N 2020 N DB14840 L01EX19 CHEMBL4216467 Advanced Gastrointestinal Stromal Tumor (GIST) KIT; PDGFRA 30/09/2021
Rituximab Y Y N Y 1997 N DB00073 L01FA01 CHEMBL1201576 Chronic Lymphocytic Leukaemia (CLL); Non-Hodgkin's Lymphoma (NHL) MS4A1; FCGR2A; IL2; TGFB1; IL10; IL6; GSTA1; CXCL13; FCGR3A; LOH19CR1; XIAP; CXCL12 01/02/2022
Rituximab, Hyaluronidase N Y N N 1997 N DB00073 L01XC02 CHEMBL1201576 Chronic Lymphocytic Leukaemia (CLL); Non-Hodgkin's Lymphoma (NHL) MS4A1; FCGR2A; IL2; TGFB1; IL10; IL6; GSTA1; CXCL13; FCGR3A; LOH19CR1; XIAP; CXCL12 17/09/2020
Romidepsin Y Y N N 2009 Y DB06176 L01XH02 CHEMBL343448 Refractory peripheral cutaneous T-cell lymphoma HDAC1; HDAC3; HDAC4; HDAC9; HDAC2; HDAC6; HDAC8; HDAC5; HDAC10; HDAC7; HDAC11; MCL1; CDKN2D; CDKN1A; CTAG1B; KMT2A; BIRC5 01/02/2022
Rucaparib Y Y N N 2016 N DB12332 L01XK03 CHEMBL1173055 Advanced Ovarian Cancer PARP3; PARP1; PARP2; PALB2; STAG2; SLC47A1; BRCA2; SLC22A6; ATR; SLC22A8; SLC47A2; BRCA1 01/02/2022
Ruxolitinib Y Y N N 2011 N DB08877 L01EJ01 CHEMBL1789941 Post Polycythemia Vera Myelofibrosis; Refractory Polycythemia vera JAK2; JAK3; JAK1; VHL; MPL; CRLF2; CSF3R; PLAUR 22/06/2022
Sacituzumab Govitecan Y Y N N 2020 N DB12893 L01FX17 CHEMBL3545262 Metastatic Triple-negative Breast Cancer 31/01/2022
Selinexor Y Y N N 2019 N DB11942 L01XX66 CHEMBL3545185 Refractory Multiple Myeloma XPO1 10/03/2021
Selpercatinib Y Y N N 2020 N DB15685 L01EX22 CHEMBL4559134 Advanced RET-fusion thyroid cancer; Advanced RET-mutant medullary thyroid cancer; Metastatic RET-fusion Non Small Cell Lung Cancer; Metastatic RET-fusion thyroid cancer; Metastatic RET-mutant medullary thyroid cancer 01/02/2022
Sipuleucel-T N Y N N 2010 N DB06688 L03AX17 CHEMBL1237024 Asymptomatic, metastatic hormone-refractory Prostate cancer; Minimally symptomatic, metastatic hormone-refractory Prostate cancer 17/09/2020
Sonidegib Y Y N N 2015 N DB09143 L01XJ02 CHEMBL2105737 Refractory, locally advanced Basal cell carcinoma SMO; MYCN; SUFU; PTCH1; EGFR 01/02/2022
Sorafenib Y Y N N 2005 Y DB00398 L01EX02 CHEMBL1336 Advanced Renal Cell Carcinoma; Gastrointestinal Stromal Tumors; Hemangiosarcoma; Unresectable Hepatocellular Carcinoma; Locally recurrent refractory to radioactive iodine treatment Thyroid carcinoma; Metastatic refractory to radioactive iodine treatment Thyroid carcinoma KDR; FLT3; RET; BRAF; RAF1; FLT4; PDGFRB; KIT; ARAF; HMOX1; UGT1A9; MAPK6; SLC15A2; FGF3; GALNT14; PTPN6; MAPK4; SLC22A1; MAPK7; ARID1A 14/11/2022
Sotorasib Y Y N N 2021 N DB15569 L01XX73 CHEMBL4535757 Locally Advanced Non-Small Cell Lung Cancer, Metastatic Non-Small Cell Lung Cancer 01/02/2022
Streptozocin N Y N N 2005 N DB00428 L01AD04 CHEMBL1603; CHEMBL1651906 Stage 4 islet cell carcinoma SLC2A4; SULT1A2; ADCYAP1; SLC2A5; IGFBP1; ATF2; VWF; S100B; HGF; SSTR1; GALP; SLC16A3; PRKAA1; THRSP; ACP5; SFTPB; ENO2; DDIT3; RAMP3; PREP; CYP7B1; MMP2; OGA; MYO9B; KCNA2; KCNJ11; TH; SI; UCP1; SST; CDKN1B; MT1H; CD40; HP; PTGER4; LCAT; CTSD; SLC5A1 01/02/2022
Sunitinib Y Y N N 2006 Y DB01268 L01EX01 CHEMBL535 Advanced Renal Cell Carcinoma; Soft Tissue Sarcoma (STS); Thyroid Cancers; Metastatic Pancreatic Neuroendocrine Tumors; Refractory Gastrointestinal stromal tumor; Unresectable, locally advanced Pancreatic Neuroendocrine Tumors PDGFB; PDGFC; PDGFRB; FLT4; FLT3; CSF1R; PDGFD; KIT; KDR; FLT1; PDGFA; RET; PDGFRA; PTPRB; NOS3; HMOX1; VHL; ABCG2; PBRM1; VEGFC; SLCO1B3; EWSR1; BAP1; NR1I3; POR; PTPN12; IL13; KDM5C 14/11/2022
Tafasitamab Y Y N N 2020 N DB15044 L01FX12 CHEMBL4298047 Refractory Diffuse large B-cell lymphoma NOS; Relapsed Diffuse large B-cell lymphoma NOS TNFRSF8 01/02/2022
Tagraxofusp Y Y N N 2018 N DB14731 L01XX67 CHEMBL4297573 Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN) IL3RA; CSF2RB 16/07/2021
Talazoparib Y Y N N 2018 N DB11760 L01XK04 CHEMBL3137320 Locally Advanced Breast Cancer (LABC); Metastatic Breast Cancer PARP2; PARP1; ATM; PTEN; SLFN11; BRCA1; PSMD4; BRCA2 01/02/2022
Talimogene Laherparepvec Y Y N N 2015 N DB13896 L01XX51 CHEMBL2108727 Unresectable Skin Lesion 17/09/2020
Tamoxifen N Y Y Y 1977 Y DB00675 L02BA01 CHEMBL83 Breast Cancer; Desmoid Tumors; Endometrial Cancer; Invasive Breast Cancer; Invasive Breast Carcinoma; Metastatic Breast Cancer; Ovarian Cancer ESR2; ESR1; KLK3; GGT1; FMO1; NCOA1; TGM2; PLD1; E2F7; CCND1; PLD2; GAPDH; EDN1; PIP; CETP; LRMDA; F5; HEXB; HSPB2; CCNA2; PGR; MUC16; COL18A1; MYOD1; NCOA3; TFF3; ZNF423; RRAS2; FMO3; DHFR 22/06/2022
Tazemetostat N Y N N 2020 N DB12887 L01XX72 CHEMBL3414621 Locally Advanced Epithelioid Sarcoma; Metastatic Epithelioid Sarcoma EZH2; SMARCB1; SMARCA4; KRAS; KDM6A 01/02/2022
Tebentafusp Y Y N N 2022 N DB15283 L01XX75 CHEMBL4297990 Metastatic Uveal Melanoma (UM), Unresectable Uveal Melanoma PMEL; TRBV20OR9-2; CD3G 23/10/2022
Teclistamab Y N N N 2022 N DB16655 CHEMBL4594505 Multiple Myeloma 23/10/2022
Tegafur, Gimeracil, Oteracil Y N N N 2011 DB09256 L01BC03; L01BC53 CHEMBL20883 Advanced Gastric Cancer TYMS; UMPS; DPYD; EGFR 01/02/2022
Tegafur, Uracil N N N Japan N DB09256 L01BC03; L01BC53 CHEMBL20883 Advanced Gastric Cancer TYMS; UMPS; DPYD; EGFR 01/02/2022
Temoporfin Y N N N 2001 N DB11630 L01XD05 CHEMBL500576 Advanced Head and Neck Squamous Cell Carcinoma 17/09/2020
Temozolomide Y Y N N 1999 Y DB00853 L01AX03 CHEMBL810 Advanced Melanoma; Glioblastomas; Primary Central Nervous System Lymphoma (PCNSL); Refractory Ewing Sarcoma; Refractory Neuroblastoma; Soft Tissue Sarcoma (STS); Advanced Neuroendocrine tumor; Refractory Anaplastic astrocytoma; Refractory, advanced Mycosis fungoides; Refractory, advanced Sezary Syndrome SLFN11; HDAC4; CSF2; PRL; STAG2; ATRX; ATM; H2AX; MGMT; NOTCH1; BRCA2; MSH6 14/11/2022
Temsirolimus Y Y N N 2007 Y DB06287 L01EG01 CHEMBL1201182 Advanced Renal Cell Carcinoma MTOR; BRAF; FKBP1A; CTNNB1; NF2; PIK3CA; PTEN; VHL; FBXW7; KRAS; AKT1 01/02/2022
Tepotinib Y Y N N 2021 N DB15133 L01EX21 CHEMBL3402762 Metastatic Non-Small Cell Lung Cancer MET 31/01/2022
Thalidomide Y Y N Y 1998 N DB01041 L04AX02 CHEMBL468 Multiple Myeloma (MM); Waldenstrom's Macroglobulinemia (WM); Treatment naive multiple myeloma RBX1; CRBN; CUL4A; DDB1; TNF; PTGS2; FGFR2; SPG7; XRCC5; GSTT1; CYP4B1; CTLA4; CHST3; ITGB2; ATP7A; FGF2; CTNNB1; F2R; ABCC6; VWF; RPL13; HGF; NAT2; SULT1C4; ERCC1; HLA-B; IL6R; FCGR3B; SLC10A2; FCGR3A; SNORD68 01/02/2022
Thiotepa Y Y N N 1959 Y DB04572 L01AC01 CHEMBL671 Adenocarcinoma of the Ovaries; Breast Adenocarcinoma; Papillary transitional cell carcinoma of bladder; Malignant effusion CYP2B6; GSTP1 14/11/2022
Tioguanine N Y N Y 1966 N DB00352 L01BB03 CHEMBL727 Acute Nonlymphocytic Leukemia; Nonlymphocytic Acute myeloid leukemia IMPDH2; IMPDH1; DOK5; GGH; TPM3; MGMT; NUDT15; PRPS1; LINC00251; GDA; TPMT; NT5C2; GATA3; ACHE; ABCC4; MYC; BMP7 01/02/2022
Tisagenlecleucel Y Y N N 2017 N DB13881 L01XX71 CHEMBL3301574 Refractory B-cell precursor acute lymphoblastic leukemia; Second or later relapsed B-cell precursor acute lymphoblastic leukemia CD19; MS4A1 17/09/2020
Tivozanib Y Y N N 2017 N DB11800 L01EK03 CHEMBL1289494 Advanced Renal Cell Carcinoma; Renal Cell Adenocarcinoma FLT1; FLT4; KDR; BRAF; ERBB2 01/02/2022
Topotecan Y Y N N 1996 Y DB01030 L01CE01 CHEMBL84 Acute Myeloid Leukemia (AML); Ewing's Sarcoma; Refractory Neuroblastoma; Metastatic Rhabdomyosarcoma; Recurrent, IV-B Cervical cancer; Refractory CNS lymphoma; Refractory CNS malignancy; Refractory, metastatic Ovarian cancer; Relapsed Small cell lung cancer TOP1MT; TOP1; TYMS; ATRX; BDNF; RB1; MUC16; ALK; DDO; AKT1; ABCG2 01/02/2022
Toremifene Y Y N N 1997 Y DB00539 L02BA02 CHEMBL1655 Desmoid Tumors; Metastatic Breast Cancer ESR1; ESR2; PGR; CYP1B1; TGFB1; CD80 17/09/2020
Trabectedin Y Y N N 2015 N DB05109 L01CX01 CHEMBL450449 Metastatic Leiomyosarcoma; Metastatic Liposarcoma; Relapsed platinum-sensitive Ovarian cancer; Unresectable Leiomyosarcoma; Unresectable Liposarcoma FGFR2; ABCB1; PARP1 01/02/2022
Trametinib Y Y N N 2013 N DB08911 L01EE01 CHEMBL2103875 Metastatic Melanoma; Unresectable Melanoma MAP2K3; MAP2K1; MAP2K6; MAP2K4; MAP2K5; MAP2K2; MAP2K7; GNA11; ARAF; ATXN1L; ETV5; ETV4; ETV1; NF1; NRAS; DDX43; STAG2; BRAF; STK11; CDKN2A; DUSP6; RB1; KRAS; RASA1; RAF1; ERBB3; CIC; GNAQ; HRAS; VHL; CTNNB1 01/02/2022
Trastuzumab Y Y N Y 1998 N DB00072 L01FD01 CHEMBL1201585 Breast Cancer; Early Breast Cancer; Inflammatory Breast Cancer (IBC); Locally Advanced Breast Cancer (LABC); Metastatic Adenocarcinoma of the Gastro-Esophageal Junction; Metastatic Adenocarcinoma of the Stomach; Metastatic Breast Cancer; Metastatic Gastric Adenocarcinoma; Metastatic Gastroesophageal Junction Adenocarcinoma ERBB2; AKT2; FCGR2A; IFNG; FCGR3A; RNF8; BARD1; BIRC5; ERBB3; APC; PPCDC; PIK3CA; EPCAM; PGR; PTEN 01/02/2022
Trastuzumab Deruxtecan Y Y N N 2019 N DB14962 L01FD04 CHEMBL4297844 HER2 Positive Breast Cancers ERBB2 01/02/2022
Trastuzumab Emtansine Y Y N N 2013 N DB05773 L01FD03 CHEMBL1743082 Refractory, metastatic Non small cell lung cancer TUBA1A; TUBB8; TUBB3; TUBB2A; TUBA3E; TUBA4A; TUBA3D; TUBA1C; TUBB6; TUBB4B; TUBA1B; TUBB2B 01/02/2022
Trastuzumab, Hyaluronidase Y Y N N 1998 N DB00072 L01XC03 CHEMBL1201585 Breast Cancer; Early Breast Cancer; Inflammatory Breast Cancer (IBC); Locally Advanced Breast Cancer (LABC); Metastatic Adenocarcinoma of the Gastro-Esophageal Junction; Metastatic Adenocarcinoma of the Stomach; Metastatic Breast Cancer; Metastatic Gastric Adenocarcinoma; Metastatic Gastroesophageal Junction Adenocarcinoma ERBB2; AKT2; FCGR2A; IFNG; FCGR3A; RNF8; BARD1; BIRC5; ERBB3; APC; PPCDC; PIK3CA; EPCAM; PGR; PTEN 01/02/2022
Tretinoin N Y Y N 1971 Y DB00755 D10AD01; L01XF01 CHEMBL38 FAB classification M3 Acute promyelocytic leukemia RXRB; RARG; RXRG; RARRES1; RARA; RARB; MYCN; FUS; CDKN1B; BCL2; PML; BCOR; NPM1; HSPA8; P2RY2; BIRC5; SMAD2; FLT3; IL10 14/11/2022
Trifluridine, Tipiracil Y Y N N 1980 Y DB00432 L01BC59; S01AD02 CHEMBL1129 Metastatic Colorectal Cancer (MCRC) ERBB2; TP53; SLC29A1 01/02/2022
Triptorelin N Y Y N 2000 N DB06825 L02AE04 CHEMBL1201334 Advanced Prostate Cancer GNRHR; STS 17/09/2020
Trofosfamide N N Y N DB12902 L01AA07 CHEMBL462019 CYP2B6 22/09/2020
Tucatinib Y Y N N 2020 N DB11652 L01EH03 CHEMBL3989868 Breast Cancer; Unresectable Breast Cancer ERBB2 22/06/2022
Umbralisib N Y N N 2021 N DB14989 L01EX25 CHEMBL3948730 B-cell Follicular Lymphoma; Marginal Zone Lymphoma (MZL) 23/10/2022
Valrubicin N Y N N 1998 Y DB00385 L01DB09 CHEMBL1096885 In situ BCG-refractory Bladder carcinoma TOP2A; TOP2B 17/09/2020
Vandetanib Y Y N N 2011 N DB05294 L01EX04 CHEMBL24828 Metastatic Medullary Thyroid Cancer; Locally advanced Medullary thyroid cancer EPHB1; EGFR; EPHA4; KDR; RET; EPHB3; EPHA5; EPHA8; EPHB4; PTK6; EPHB2; EPHA1; EPHA10; EPHB6; EPHA3; EPHA7; EPHA6; APC 01/02/2022
Vemurafenib Y Y N N 2011 N DB08881 L01EC01 CHEMBL1229517 Metastatic Melanoma; Unresectable Melanoma; Refractory Non-small cell lung cancer BRAF; PREX2; CIC; CDKN2A; STAG3; AKT3; MAP2K1; MAP2K2; PTEN; STAG2; PIK3R2; NRAS; NF1; ATXN1L; RAC1; SOX10 01/02/2022
Venetoclax Y Y N N 2016 N DB11581 L01XX52 CHEMBL3137309 Chronic Lymphocytic Leukaemia (CLL); Small Lymphocytic Lymphoma BCL2; FLT3; NPM1; BRAF; IGH; PTEN; IDH2 22/06/2022
Vinblastine N Y Y Y 1965 Y DB00570 L01CA01 CHEMBL159 Advanced Soft Tissue Sarcoma; Cancer, Bladder; Kaposi's sarcoma; Lymphoma, Hodgkins; Metastatic Melanoma; Non-Small Cell Lung Carcinoma (NSCLC); Advanced Alibert-Bazin syndrome; Advanced Testicular cancer; Histiocytic lymphoma; Refractory Breast cancer TUBB; TUBA1A; TUBA3C; TUBB1; TUBB2A; TUBB2B; KLK3; CGA; GSTM1; ABCB4; TUBA1B; TUBA3E; TRH; TUBA1C; CDKN1A; TBXA2R; TUBB4B; TUBB3; TUBB4A; MMP2; PTHLH; TUBA4A; TUBB8; TUBB6; TUBA3D; CSF2 01/02/2022
Vincristine N Y Y Y 1965 Y DB00541 L01CA02 CHEMBL499458; CHEMBL90555 Acute Lymphoblastic Leukaemia Recurrent; Acute Lymphocytic Leukemia (ALL); Choriocarcinoma; Chronic Lymphocytic Leukaemia (CLL); Ewing's Sarcoma; Hepatoblastomas; Kaposi's sarcoma; Lymphoma, Hodgkins; Multiple Myeloma (MM); Neuroblastomas; Non-Hodgkin's Lymphoma (NHL); Ovarian germ cell tumour; Pheochromocytomas; Retinoblastoma; Rhabdomyosarcomas; Small Cell Lung Cancer (SCLC); Wilms' tumor; Advanced Thymoma TUBB; TUBA4A; TUBA3E; CXCL12; LINC00251; TUBB2B; BCR; TUBB3; TUBA3D; FGF2; ABCC10; CDKN1B; GATA3; AFP; TUBB4B; CEP72; TUBA1B; TUBA3C; BMP7; ODC1; DROSHA; DOK5; CP; PNPLA3; TUBA1C; TUBB6; TUBA1A; MYCN; NTF3; TUBB4A; GSTA1; ABCB4; RALBP1; TUBB2A; ACTG1; VWF; ATRX; SRI; TUBB8; CAPG 01/02/2022
Vincristine Liposome N Y N N 2012 Y DB00541 L01CA02 CHEMBL499458; CHEMBL90555 Acute Lymphoblastic Leukaemia Recurrent; Acute Lymphocytic Leukemia (ALL); Choriocarcinoma; Chronic Lymphocytic Leukaemia (CLL); Ewing's Sarcoma; Hepatoblastomas; Kaposi's sarcoma; Lymphoma, Hodgkins; Multiple Myeloma (MM); Neuroblastomas; Non-Hodgkin's Lymphoma (NHL); Ovarian germ cell tumour; Pheochromocytomas; Retinoblastoma; Rhabdomyosarcomas; Small Cell Lung Cancer (SCLC); Wilms' tumor; Advanced Thymoma TUBB; TUBA4A; TUBA3E; CXCL12; LINC00251; TUBB2B; BCR; TUBB3; TUBA3D; FGF2; ABCC10; CDKN1B; GATA3; AFP; TUBB4B; CEP72; TUBA1B; TUBA3C; BMP7; ODC1; DROSHA; DOK5; CP; PNPLA3; TUBA1C; TUBB6; TUBA1A; MYCN; NTF3; TUBB4A; GSTA1; ABCB4; RALBP1; TUBB2A; ACTG1; VWF; ATRX; SRI; TUBB8; CAPG 01/02/2022
Vindesine N N Y N 1979 N DB00309 L01CA03 CHEMBL238071 Acute Lymphocytic Leukemia (ALL); Melanoma, Malignant TUBB1; ABCB1; TUBB 01/02/2022
Vinflunine Y N N N 2009 N DB11641 L01CA05 CHEMBL2110725 Transitional Cell Carcinoma of the Urothelial Tract; Metastatic Transitional Cell Carcinoma of the Urothelial Tract TUBA3E; TUBA3D; TUBB; TUBB3; TUBB2A; TUBA1C; TUBB6; TUBA1B; TUBA1A; TUBB4B; TUBA4A; TUBB2B; TUBB8 01/02/2022
Vinorelbine N Y Y Y 1994 Y DB00361 L01CA04 CHEMBL553025 Advanced Non Small Cell Lung Cancer; Esophageal Cancers; Locally Advanced Non-Small Cell Lung Cancer; Metastatic Breast Cancer; Recurrent Cervical Cancer; Soft Tissue Sarcoma (STS); Recurrent, IV-B Cervical cancer TUBB; TUB; SMARCA4; BAX; TUBB4B; TUBB3; TUBA3D; TUBB4A; CASP7; RRM1; TUBA1C; TUBB8; TUBB6; BRCA1; TUBA1A; TUBA3C; TUBA3E; TUBA4A; BRCA2; APC; TUBB2B; TUBA1B; XRCC1; TUBB2A 01/02/2022
Vismodegib Y Y N N 2012 N DB08828 L01XJ01 CHEMBL473417 Locally Advanced Basal Cell Carcinoma; Metastatic Basal cell carcinoma PTCH1; SMO; SHH 17/09/2020
Vorinostat N Y N N 2006 N DB02546 L01XH01 CHEMBL98 Persistent Cutaneous T-Cell Lymphoma; Progressive Cutaneous T-cell lymphoma; Recurrent Cutaneous T-cell lymphoma HDAC8; HDAC3; HDAC7; HDAC1; HDAC4; HDAC11; HDAC5; HDAC2; HDAC10; HDAC6; HDAC9; CFTR; NPM1; RB1; SMARCB1; FBXW7; TUBA3C; EZH2; MYD88; TUBB4A; BAP1; CHD4; NR0B1 01/02/2022
Zanubrutinib Y Y N N 2019 N DB15035 L01EL03 CHEMBL3936761 Mantle Cell Lymphoma (MCL) BTK 30/09/2021