ReDO_DB - Drug Repurposing Database | Anticancerfund

ReDO_DB - Drug Repurposing Database

ReDO_DB is a curated listing of non-cancer drugs which have shown some evidence of anticancer activity. Data comes from peer-reviewed studies, medical case reports, observational studies and clinical trials. All drugs are also checked whether they are included in the World Health Organisation Essential Medicines List and are available off-patent. Drugs highlighted are subjects of ReDO review papers, which can be accessed by clicking on the drug name.

Cite as: Pantziarka Pan, Verbaanderd Ciska, Sukhatme Vidula, Capistrano Rica, Crispino Sergio, Gyawali Bishal, Rooman Ilse, Van Nuffel An MT, Meheus Lydie, Sukhatme Vikas P and Bouche Gauthier (2018) ReDO_DB: the repurposing drugs in oncology database ecancer 12 886

A machine-readable version of this database can be downloaded here: ReDO_DB.txt.


Important note for patients! This list identifies drugs that, based on their scientific properties, warrant further scientific investigation. In most cases the existing scientific evidence for their effects on cancer is very limited. Further scientific and clinical research is needed before any statements regarding their anti-cancer activity can be made. This list is not intended to be used as a source for possible treatment options for patients.

If you need help exploring further treatment options for your situation, please take a look at our My Cancer Navigator service.


Summary results as of last build on: 02/09/21

NumberPercentageNumberPercentage
Total number of drugs included in ReDO database357100.0%Drugs with observational studies5615.7%
Drugs included in WHO EML12234.2%Drugs with clinical trials23465.5%
Drugs which are off-patent30786.0%Drugs with published trial reports16168.8%
Drugs with in vitro evidence34797.2%Drugs for which human data exists25671.7%
Drugs with in vivo evidence32992.2%WHO + Off-patent + Human data9025.2%
Drugs with case(s) reports10930.5%Number of unique molecular targets1105-


Click in header cell to sort table by that column. Hover over header cell for additional text. Click on Links cell for additional resources

Database build date: 02/09/21

Number of drugs in database: 357 (Filter not active)



Drug Synonym Main Indications WHO Off-Patent Vitro Vivo Cases Obs. Trials Human Targets Date Update Links
Acetaminophen Paracetamol Analgesia Yes Yes Yes Yes Yes Yes Yes Yes PTGES3; PTGS2; PTGS1; TRPV1; 13/07/2017 Links
Acetazolamide Glaucoma, diuretic, epilepsy Yes Yes Yes Yes No No Yes Yes CA1; CA2; CA4; CA12; CA14; CA3; CA7; AQP1; 12/07/2017 Links
Acetylsalicylic Acid Aspirin Analgesia, swelling, prophylaxis of venous embolism and further heart attacks or strokes Yes Yes Yes Yes No Yes Yes Yes PTGS1; PTGS2; AKR1C1; PRKAA1; EDNRA; TP53; HSPA5; RPS6KA3; NFKBIA; TNFAIP6; CASP1; CASP3; IKBKB; MAPK1; CCND1; MYC; PCNA; 23/08/2017 Links
Adapalene Acne No Yes Yes Yes No No No No RARB; RARG; RXRB; RXRG; RXRA; JUN; TLR2; RARA; GOT1; 05/02/2020 Links
Ademetionine AdoMet, S-Adenosylmethionine Liver disease No Yes Yes Yes No No Yes Yes GNMT; AMD1; MAT2A; CBS; MAT1A; COMT; CMTR1; AS3MT; 19/09/2018 Links
Agomelatine Insomnia No No Yes No No No No No HTR2C; MTNR1A; MTNR1B; 13/07/2017 Links
Albendazole Parasitic infection Yes Yes Yes Yes Yes No Yes Yes TUBA1A; TUBB4B; 23/07/2021 Links
Alendronic Acid Alendronate Osteoporosis No Yes Yes Yes Yes No Yes Yes FDPS; PTPN4; PTPRS; PTPRE; ATP6V1A; 12/03/2018 Links
Aliskiren Essential hypertension No Yes Yes No No No No No REN; 02/08/2021 Links
Allopurinol Gout Yes Yes Yes Yes No No Yes Yes XDH; 14/07/2017 Links
Alpha-Lipoic Acid Thioctic Acid, Lipoic Acid Diabetic neuropathy (Germany) No Yes Yes Yes Yes No Yes Yes LIPT1; LIAS; SLC5A6; 14/07/2017 Links
Amantadine Parkinson's Disease, Influenza A No Yes Yes No No No No No M; GRIN3A; CHRNA7; DRD2; CHRNA4; CHRNA3; 18/07/2017 Links
Ambroxol Excessive mucus No Yes Yes Yes No No No No 19/01/2021 Links
Amiloride In congestive heart failure or hypertension treated with thiazides, to conserve potassium Yes Yes Yes Yes No No No No SCNN1A; SCNN1B; SCNN1G; SCNN1D; AOC1; ASIC2; ASIC1; SLC9A1; PLAU; 18/07/2017 Links
Aminophylline Asthma, chronic bronchitis No Yes Yes Yes No No Yes Yes PDE3A; ADORA1; ADORA3; HDAC2; 17/02/2020 Links
Amiodarone Ventricular tachycardia/fibrillation Yes Yes Yes Yes No No Yes Yes KCNH2; ADRB1; CACNA1I; CACNA1C; THRA; PPARG; PPARA; PPARGC1B; 19/07/2017 Links
Amitriptyline Depression Yes Yes Yes Yes No No No No SLC6A2; SLC6A4; HTR2A; HTR1A; OPRD1; OPRK1; NTRK1; NTRK2; ADRA1A; ADRA1D; ADRA2A; HRH1; KCNQ2; KCNA1; HRH2; HRH4; SIGMAR1; HTR2C; ADRA1B; HTR7; HTR1D; OPRM1; HTR1B; HTR6; KCNQ3; Htr2c; CHRM1; KCNH2; 07/08/2017 Links
Amlodipine Hypertension Yes Yes Yes Yes No No No No CACNA1C; CACNA1B; CACNB1; CACNA2D3; CA1; SMPD1; CACNA1I; CACNA1B; 07/08/2017 Links
Amodiaquine Malaria Yes Yes Yes No No No No No HNMT; 07/08/2017 Links
Anagrelide Essential thrombocythemia No Yes Yes Yes No No No No PDE3A; 02/08/2021 Links
Anakinra RA, NOMID, CAPS No Yes Yes Yes Yes No Yes Yes IL1R1; 02/08/2021 Links
Aprepitant Nausea, vomiting Yes Yes Yes Yes No No Yes Yes TACR1; 02/08/2021 Links
Aprotinin Perioperative blood loss No No Yes Yes No No Yes Yes PRSS1; CTRB1; PLG; KLK1; 21/08/2017 Links
Argatroban Heparin-induced thrombocytopenia No Yes Yes Yes No No No No F2; 20/03/2019 Links
Aripiprazole Bipolar disorder, major depressive disorder, autistic disorder No Yes Yes Yes No No No No HTR1A; DRD2; HTR2A; ADRA1A; ADRA1B; DRD3; HTR1D; HTR7; ADRA2A; ADRA2C; HRH1; HTR1B; HTR2C; HTR3A; HTR6; DRD1; DRD4; ADRA2B; HTR1E; DRD5; HTR2B; HTR5A; ADRB1; ADRB2; HRH2; HRH3; HRH4; CHRM1; CHRM2; CHRM3; CHRM4; CHRM5; OPRK1; OPRM1; OPRD1; GRIN1; SLC6A3; SLC6A4; 01/02/2021 Links
Artesunate Malaria Yes Yes Yes Yes Yes No Yes Yes EXP-1; 21/08/2017 Links
Ascorbic acid Ascorbate, Vitamin C Scurvy Yes Yes Yes Yes Yes No Yes Yes xylA; PLOD2; PHYH; PLOD3; BBOX1; DBH; PAM; P3H1; P3H2; P3H3; P4HA1; OGFOD1; OGFOD2; ALKBH2; ALKBH3; KDM5D; PLOD1; TMLHE; P4HTM; EGLN1; EGLN2; EGLN3; 09/08/2017 Links
Atenolol Hypertension, angina pectoris Yes Yes Yes No No No No No ADRB1; ADRB2; 21/08/2017 Links
Atorvastatin Coronary heart disease, acute coronary syndrome Yes Yes Yes Yes No Yes Yes Yes HMGCR; DPP4; AHR; HDAC2; NR1I3; 21/08/2017 Links
Atovaquone Pneumocystis carinii pneumonia, toxoplasmose No Yes Yes Yes No Yes Yes Yes MT-CYB; DHODH; 21/08/2017 Links
Atrial Natriuretic Peptide Carperitide Heart failure No No Yes Yes No Yes Yes Yes 03/08/2021 Links
Auranofin RA No Yes Yes Yes No No Yes Yes PRDX5; IKBKB; 23/08/2017 Links
Azelastine Allergies No Yes Yes Yes No No No No HRH1; HRH2; PLA2G1B; LTC4S; 28/08/2019 Links
Azithromycin Bacterial infection, CAP, PID Yes Yes Yes Yes No No Yes Yes PADI4; 23/08/2017 Links
Bazedoxifene Osteoporosis No No Yes Yes No No Yes Yes ESR1; ESR2; 24/08/2017 Links
Bedaquiline Tuberculosis Yes No Yes No No No No No atpE; 24/08/2017 Links
Bemiparin Venous thromboembolism, myocardial infarction No No Yes Yes No No Yes Yes F10; SERPINC1; SERPIND1; 24/08/2017 Links
Benserazide Parkinson's Disease No Yes Yes Yes No No No No DDC; 24/08/2017 Links
Benzatropine Benztropine Parkinson's Disease No Yes Yes Yes No No No No CHRM1; SLC6A3; HRH1; SLC6A4; SLC6A2; 12/03/2018 Links
Bepridil Hypertension and chronic stable angina No Yes Yes Yes No No No No CACNA1A; CACNA1H; CACNA2D2; ATP1A1; KCNQ1; TNNC1; CALM1; PDE1B; PDE1A; KCNH2; 24/08/2017 Links
Bezafibrate Hyperlipidemia No Yes Yes Yes No No Yes Yes PPARA; PPARD; PPARG; NR1I2; RXRA; RXRB; RXRG; 24/08/2017 Links
Biperiden Parkinson's Disease Yes Yes Yes Yes No No No No CHRM1; 24/08/2017 Links
Bosentan PAH No Yes Yes Yes No No Yes Yes EDNRA; EDNRB; 24/08/2017 Links
Brexpiprazole Schizophrenia, major depressive disorder No No Yes Yes No No No No HTR1A; DRD2; HTR2A; ADRA2C; ADRA1B; 17/02/2020 Links
Bromhexine Excessive mucus No Yes Yes Yes No No No No 19/01/2021 Links
Bromocriptine Parkinson's Disease, prevention of lactation No Yes Yes Yes No No Yes Yes DRD2; DRD3; HTR1D; ADRA2A; HTR1A; ADRA2C; ADRA2B; HTR2B; DRD4; HTR2A; HTR1B; HTR2C; DRD5; DRD1; ADRA1A; ADRA1B; ADRA1D; HTR7; 24/08/2017 Links
Cabergoline Hyperprolactinemia No Yes Yes Yes No No Yes Yes DRD2; HTR2B; DRD3; HTR2A; ADRA2B; HTR1D; DRD4; ADRA2A; HTR1A; ADRA2C; DRD5; DRD1; HTR1B; HTR2C; HTR7; ADRA1A; ADRA1B; ADRA1D; ADRB1; ADRB2; DRD1; 23/08/2017 Links
Caffeine Newborn apnea No Yes Yes Yes Yes Yes Yes Yes ADORA1; PDE4B; ADORA2A; RYR1; PDE1A; PRKDC; PIK3CD; PIK3CA; PIK3CB; ITPR1; ATM; ADORA2B; ADORA3; PDE1B; 03/08/2021 Links
Calcipotriol Vitamin D3 Psoriasis No Yes Yes Yes Yes No Yes Yes VDR; 21/03/2019 Links
Calcitriol Vitamin D3 Vitamin D deficiency No Yes Yes Yes Yes No Yes Yes VDR; HOXA10; 23/08/2017 Links
Canagliflozin Diabetes No No Yes Yes No No Yes Yes SLC5A2; 09/08/2021 Links
Candesartan Hypertension No Yes Yes Yes No No Yes Yes AGTR1; 23/08/2017 Links
Captopril Hypertension No Yes Yes Yes No No Yes Yes ACE; MMP2; MMP9; LTA4H; BDKRB1; 25/08/2017 Links
Carbimazole Hyperthyroidism Yes Yes Yes No No No No No TPO; 25/08/2017 Links
Carglumic Acid Hyperammonaemia in N-acetylglutamate synthase deficiency No Yes Yes Yes No No No No CPS1; 03/08/2021 Links
Carvedilol Hypertension Yes Yes Yes Yes No Yes Yes Yes ADRB1; ADRA1A; NDUFC2; ADRB2; VEGFA; NPPB; GJA1; KCNH2; VCAM1; ADRA1D; ADRA1B; ADRA2C; ADRA2B; ADRA2A; SELE; HIF1A; KCNJ4; KCNJ2; ADRA1A; 27/02/2021 Links
Celecoxib OA, RA, JRA, AS, acute pain, primary dysmenorrhea No Yes Yes Yes Yes Yes Yes Yes PTGS2; PDPK1; CA2; CA3; CDH11; 03/08/2021 Links
Cephalexin Bacterial infections No Yes Yes Yes No No Yes Yes pbp3; pbp2a; pbp1b; penA; pbpA; 25/08/2017 Links
Chloramphenicol Superficial eye infections, typhoid fever Yes Yes Yes No Yes No No Yes rplP; draA; CD55; 28/02/2018 Links
Chloroquine Malaria, Extraintestinal Amebiasis Yes Yes Yes Yes Yes No Yes Yes GSTA2; TNF; TLR9; GST; HMGB1; GSTM1; ACE2; 06/08/2021 Links
Chlorpromazine Psychotic disorders, nausea and vomiting, anxiety, hiccups Yes Yes Yes Yes No No Yes Yes DRD2; DRD1; HTR1A; HTR2A; ADRA1A; ADRA1B; HRH1; KCNH2; DRD1; DRD3; DRD4; DRD5; HTR2C; HTR2A; ADRA1A; ADRA2A; CHRM1; CHRM3; SMPD1; CALM1; ORM1; HTR6; HTR7; HRH4; 25/08/2017 Links
Cholecalciferol Colecalciferol, Vitamin D3 Vitamin D deficiency Yes Yes Yes Yes Yes No Yes Yes VDR; 25/08/2017 Links
Cholera Vaccine Vibrio cholerae vaccine Active immunization against cholera infection Yes N/A No Yes No Yes No Yes 24/06/2021 Links
Cidofovir CMV-retinitis in AIDS No Yes Yes Yes Yes No Yes Yes UL54; 06/08/2021 Links
Cilnidipine Hypertension No Yes Yes Yes No No No No CACNA1B; CACNA1C; 30/08/2017 Links
Cilostazol Intermittent claudication No Yes Yes Yes No No No No PDE3A; 24/09/2020 Links
Cimetidine Duodenal/gastric ulcers, GERD, pathological hypersecretory conditions Yes Yes Yes Yes Yes No Yes Yes HRH2; 31/08/2017 Links
Ciprofloxacin Antibiotic Yes Yes Yes Yes No No Yes Yes parC; gyrA; TOP2A; KCNH2; gyrA; parC; parE; gyrA; mdtK; gyrA; 21/09/2017 Links
Citalopram Depression No Yes Yes Yes No No Yes Yes SLC6A4; HRH1; 31/08/2017 Links
Clarithromycin Bacterial infections Yes Yes Yes Yes Yes No Yes Yes rplJ; KCNH2; SLCO1B1; SLCO1B3; 31/08/2017 Links
Clemastine Allergies No Yes Yes No No No No No HRH1; 21/08/2019 Links
Clioquinol Anti-fungal, anti-infective No Yes Yes Yes No No Yes Yes 10/03/2020 Links
Clodronic Acid Clodronate Osteolytic lesions, hypercalcaemia and bone pain associated with skeletal metastases in patients with breast cancer or multiple myeloma No Yes Yes Yes Yes No Yes Yes SLC25A4; SLC25A5; SLC25A6; 02/07/2018 Links
Clofazimine Leprosy Yes Yes Yes Yes No No Yes Yes PPARG; KCNA3; 19/03/2019 Links
Clofoctol Bacterial infections No Yes Yes Yes No No No No 31/08/2017 Links
Clomifene Ovulatory dysfunction Yes Yes Yes Yes No No Yes Yes ESR1; SHBG; 31/08/2017 Links
Clomipramine Obsessive Compulsive Disorder Yes Yes Yes Yes No No No No SLC6A4; HTR2A; HTR2B; HTR2C; SLC6A2; GSTP1; 31/08/2017 Links
Clopidogrel Stroke, post-myocardial infarction Yes Yes Yes Yes No No Yes Yes P2RY12; 01/03/2018 Links
Clotrimazole Fungal infections Yes Yes Yes Yes No No No No ERG11; KCNN4; NR1I2; HCAR2; 31/08/2017 Links
Colchicine Gout No Yes Yes Yes No No Yes Yes TUBB; 31/08/2017 Links
Cromoglicic Acid Cromolyn, Cromoglycate, Cromoglicate Asthma prophylaxis No Yes Yes Yes No No No No S100P; 19/08/2020 Links
Cyclosporine Cyclosporin Graft versus host disease No Yes Yes Yes Yes No Yes Yes CAMLG; PPP3R2; PPIA; PPIF; 01/02/2021 Links
Cyproheptadine Allergies No Yes Yes Yes Yes Yes Yes Yes HRH1; HTR2A; HTR2C; CHRM1; CHRM2; CHRM3; HTR7; 17/02/2020 Links
Dalteparin DVT (prophylaxis), unstable angina/non-Q-wave myocardial infarction Yes Yes Yes Yes Yes No Yes Yes SERPINC1; VEGFA; TFPI; SELP; 31/08/2017 Links
Danazol Endometriosis, fibrocystic breast disease, hereditary angioedema No Yes Yes Yes No No Yes Yes ESR1; AR; PGR; GNRHR; GNRHR2; CCL2; 01/09/2017 Links
Dapsone Dermatitis herpetiformis, leprosy Yes Yes Yes Yes No No Yes Yes folP2; folP1; 01/09/2017 Links
Deferasirox Acute iron intoxication, chronic iron overload No Yes Yes Yes No No Yes Yes 10/08/2021 Links
Deferiprone Iron overload in thalassemia major No Yes Yes Yes No No No No 14/08/2018 Links
Deferoxamine Desferrioxamine Acute iron intoxication, chronic iron overload Yes Yes Yes Yes No No Yes Yes APP; 01/09/2017 Links
Defibrotide Severe hepatic veno-occlusive disease No No Yes Yes No No Yes Yes ADORA1; ADORA2A; ADORA2B; 18/03/2021 Links
Desloratadine Allergies No Yes Yes No No Yes No Yes HRH1; 21/10/2020 Links
Desmopressin Diabetes Insipidus, bedwetting, hemophilia A, von Willebrand's disease Yes Yes Yes Yes No No Yes Yes AVPR2; AVPR1A; AVPR1B; 01/09/2017 Links
Diazoxide Chronic intractable hypoglycaemia, acute hypertension Yes Yes Yes Yes Yes No Yes Yes KCNJ11; CA1; CA2; ATP1A1; KCNMA1; 21/08/2019 Links
Diclofenac OA, RA, AS No Yes Yes Yes Yes No Yes Yes PTGS2; PTGS1; 01/09/2017 Links
Diflunisal OA, RA, mild to moderate pain No Yes Yes Yes No No No No PTGS2; PTGS1; 01/09/2017 Links
Digitoxin Congestive HF, atrial fibrillation, atrial flutter, PAT, cardiogenic shock No Yes Yes Yes No No Yes Yes ATP1A1; 01/09/2017 Links
Digoxin Heart failure, atrial fibrillation Yes Yes Yes Yes No No Yes Yes ATP1A1; 01/09/2017 Links
Dimethyl Fumarate Psoriasis, Multiple Sclerosis No Yes Yes Yes No No Yes Yes KEAP1; RELA; 01/09/2017 Links
Diphtheria vaccine Diphtheria Toxoid, DTP vaccine, DT vaccine, Td vaccine Active immunization against diphtheria infection Yes N/A Yes Yes Yes No Yes Yes 24/06/2021 Links
Dipyridamole Thromboembolism Prophylaxis Post-Cardiac Valve Replacement No Yes Yes Yes No No Yes Yes PDE10A; ADA; PDE5A; PDE4A; RCAN1; ORM1; 01/09/2017 Links
Disulfiram Chronic alcoholism No Yes Yes Yes Yes No Yes Yes ALDH2; DBH; 06/08/2021 Links
Donepezil Alzheimer's Disease No Yes Yes Yes No No Yes Yes ACHE; HTR2A; BCHE; NOS1; TNFAIP6; IL1B; NFKB2; GRIN1; 17/10/2017 Links
Doxazosin Hypertension, benign prostatic hyperplasia No Yes Yes Yes No No No No ADRA1A; ADRA1D; KCNH2; ADRA1B; 17/10/2017 Links
Doxycycline Respiratory/urinary tract/ophtalmic infection Yes Yes Yes Yes Yes No Yes Yes 17/10/2017 Links
Dronedarone Paroxysmal or persistent atrial fibrillation No Yes Yes Yes No No No No ADRA1A; ADRA1B; ADRA1D; ADRA2A; ADRA2B; ADRA2C; ADRB1; KCNH2; CACNA1C; CACNA1D; CACNA1F; CACNA1S; CACNB1; CACNB2; CACNB3; CACNB4; KCNK2; SCN5A; KCNJ3; KCNQ1; KCNJ12; SLC8A1; KCND3; THRA; 19/12/2018 Links
Dutasteride Benign prostatic hyperplasia No Yes Yes Yes Yes No Yes Yes SRD5A2; SRD5A1; 14/08/2018 Links
Ebastine Allergies No Yes Yes Yes No No No No 17/10/2017 Links
Efavirenz Anti-retroviral Yes Yes Yes Yes No No Yes Yes pol; 17/10/2017 Links
Eflornithine DFMO Adjunct to laser therapy for facial hirsutism in women, African trypanosomiasis Yes Yes Yes Yes Yes No Yes Yes ODC1; 26/10/2017 Links
Eltrombopag Chronic immune (idiopathic) thrombocytopenia No No Yes Yes No No Yes Yes MPL; 17/02/2021 Links
Emetine Amoebiasis No Yes Yes Yes No No No No 17/02/2020 Links
Enalapril Hypertension Yes Yes Yes Yes No No Yes Yes ACE; 26/10/2017 Links
Enoxacin Urinary tract infections No Unclear Yes Yes No No No No gyrA; parC; TOP2A; 19/08/2020 Links
Enoxaparin Prophylaxis of venous thromboembolism Yes Yes Yes Yes No No Yes Yes SERPINC1; F10; 26/10/2017 Links
Epalrestat Diabetes No Yes Yes Yes No No Yes Yes 26/10/2017 Links
Esomeprazole Antacid No Yes Yes Yes Yes Yes Yes Yes ATP4A; DDAH1; 26/10/2017 Links
Ethacrynic Acid Etacrynic acid Diuretic No Yes Yes Yes Yes No No Yes ATP1A1; SLC12A1; LEF1; GSTP1; 26/10/2017 Links
Etodolac Analgesia No Yes Yes Yes Yes No Yes Yes PTGS2; PTGS1; RXRA; 26/10/2017 Links
Etoricoxib OA, RA, AS No Yes Yes Yes No No Yes Yes PTGS2; 19/03/2019 Links
Famotidine Antacid No Yes Yes Yes No No Yes Yes HRH2; 26/10/2017 Links
Fasudil Vasodilator No Unclear Yes Yes No No No No PKIA; PRKACA; ROCK1; ROCK2; 26/10/2017 Links
Felodipine Hypertension No Yes Yes Yes No No No No CACNA1C; CACNA2D1; CACNB2; CACNA1D; CACNA1S; CACNA1H; CACNA2D2; CALM1; PDE1B; PDE1A; NR3C2; TNNC2; TNNC1; 26/10/2017 Links
Fenofibrate Hyperlipidemia No Yes Yes Yes Yes No Yes Yes PPARA; MMP25; NR1I2; 26/10/2017 Links
Fenoldopam Acute hypertension No Yes Yes Yes No No No No DRD5; DRD1; ADRA2B; ADRA2C; ADRA2A; ADRA1B; ADRA1D; ADRA1A; 21/08/2019 Links
Finasteride Benign prostatic hyperplasia No Yes Yes Yes Yes Yes Yes Yes SRD5A2; SRD5A1; AKR1D1; 14/08/2018 Links
Fingolimod Multiple Sclerosis No Yes Yes Yes No No Yes Yes S1PR5; HDAC1; S1PR1; S1PR4; S1PR3; 06/08/2021 Links
Flubendazole Parasitic infection No Yes Yes Yes No No No No 30/10/2017 Links
Flucytosine 5-Fluorocytosine Candida and/or Cryptococcus Yes Yes Yes Yes No No Yes Yes DNMT1; TMP1; 27/06/2018 Links
Flunarizine Migraine No Yes Yes Yes No No No No CACNA1G; CACNA1H; CACNA1I; HRH1; CALM1; 19/12/2018 Links
Fluoxetine Prozac Depression Yes Yes Yes Yes No No No No SLC6A4; HTR2C; CHRNA2; CHRNA3; CHRNB4; CKS1B; KCNH2; 30/10/2017 Links
Fluphenazine Psychotic disorders Yes Yes Yes Yes No No Yes Yes DRD2; DRD1; CALM1; AR; HTR2A; HTR2C; 01/05/2019 Links
Flurbiprofen Analgesia No Yes Yes Yes No Yes Yes Yes PTGS1; PTGS2; 09/08/2018 Links
Fluspirilene Psychotic disorders No Yes Yes Yes No No No No DRD2; HTR2A; CACNG1; 30/10/2017 Links
Fluvastatin Hyperlipidemia Yes Yes Yes Yes Yes Yes Yes Yes HMGCR; HDAC2; 31/10/2017 Links
Fluvoxamine Depression No Yes Yes Yes Yes No No Yes SLC6A4; KCNH2; 31/10/2017 Links
Fostamatinib Chronic immune thrombocytopenia No No Yes Yes No No Yes Yes SYK; ADORA3; VMAT2; FAAH; SLC29A1; UGT1A1; PDE5A; ALOX5; CTSS; CTSL; ABL1; CPK1; pknB; RPS6KA6; TYK2; COQ8A; JAK1; MET; NIM1K; STK26; PRKACA; STK24; STK3; TEC; STK33; STK35; STK36; STK38; STK38L; STK39; TAOK1; TAOK2; TAOK3; TBK1; TEK; TESK1; TGFBR1; TGFBR2; TIE1; TLK1; TLK2; TNIK; TNK1; TNK2; TNNI3K; TSSK1B; TTK; TXK; TYRO3; ULK1; ULK2; ULK3; WEE1; YES1; MAP3K19; ZAK; ZAP70; AAK1; ABL2; ACVR1; ACVR1B; COQ8B; ALK; ANKK1; AURKA; AURKB; AURKC; AXL; BLK; BMP2K; BMPR1B; BMPR2; BMX; BRAF; BTK; CAMK1; CAMK1D; CAMK1G; CAMK2A; CAMK2B; CAMK2D; CAMK2G; CAMKK1; CAMKK2; CASK; CSN3; CDK1; CDC42BPG; CDK4; CDKL1; CDKL2; CHEK1; CHEK2; CIT; CLK1; CLK2; CLK3; CLK4; CSF1R; CSK; CSNK1A1; CSNK2A1; CSNK2A2; DAPK1; DAPK2; DAPK3; DCLK1; DCLK2; DCLK3; DDR1; DDR2; DYRK1A; DYRK1B; EGFR; EIF2AK1; EIF2AK2; EIF2AK4; EPHA1; EPHA2; EPHA3; EPHA4; EPHA5; EPHA6; EPHA7; EPHA8; EPHB1; EPHB2; EPHB4; EPHB6; ERBB2; ERBB4; ERN1; FER; FES; FGFR1; FGFR2; FGFR3; FGR; FLT1; FLT3; FLT4; MTOR; FRK; FYN; GAK; GSK3A; GSK3B; HCK; HIPK2; HIPK3; ICK; IKBKB; IKBKE; INSR; INSRR; IRAK1; IRAK3; IRAK4; ITK; JAK2; JAK3; KDR; SIK3; KIT; LATS1; LCK; LIMK1; LIMK2; LRRK2; LTK; LYN; MAP2K2; MAP2K3; MAP2K5; MAP2K6; MAP3K1; MAP3K10; MAP3K11; MAP3K12; MAP3K13; MAP3K15; MAP3K2; MAP3K3; MAP3K4; MAP3K6; MAP3K9; MAP4K1; MAP4K2; MAP4K3; MAP4K4; MAP4K5; MAPK10; MAPK13; MAPK14; MAPK15; MAPK4; MAPK7; MAPK9; MAPKAPK5; MARK1; MARK2; MARK3; MARK4; CLASP1; MAST1; MATK; MELK; MERTK; MINK1; MKNK1; MKNK2; MST1R; MUSK; MYLK; MYLK2; MYLK3; MYLK4; MYO3A; NEK1; NEK11; NEK2; NEK3; NEK4; NEK5; NEK9; NTRK1; NTRK2; NTRK3; NUAK1; NUAK2; OXSR1; PAK1; PAK2; PAK3; PAK4; PAK6; PAK5; CDK16; CDK17; PDGFRA; PDGFRB; PDPK1; CDK15; PHKG1; PI4KB; PIK3C2B; PIK3C2G; PIK3CD; PIK3CG; PIM1; PIM3; PIP4K2B; PIP4K2C; PKMYT1; PKN1; PKN2; PLK1; PLK2; PLK3; PLK4; PRKAA1; PRKAA1; PRKACB; PRKCD; PRKCE; PRKCG; PRKCI; PRKCQ; PRKD1; PRKG2; PRPF4B; PTK2; PTK2B; PTK6; RAF1; RET; RIOK1; RIOK2; RIOK3; RIPK1; RIPK2; RIPK4; ROCK2; ROS1; RPS6KA1; RPS6KA3; SBK1; SBK3; SGK3; SIK1; SIK2; SLK; SNRK; SRC; SRMS; STK10; STK16; STK17A; STK17B; STK32A; 04/03/2021 Links
Ganciclovir Anti-viral No Yes Yes Yes Yes No Yes Yes TK; 28/06/2018 Links
Glibenclamide Glyburide Diabetes No Yes Yes Yes No No No No ABCC8; ABCC9; ABCB11; ABCA1; KCNJ11; CPT1A; CFTR; TRPM4; 03/04/2018 Links
Glipizide Diabetes No Yes Yes Yes No No No No ABCC8; PPARG; 01/11/2017 Links
Griseofulvin Fungal infections Yes Yes Yes Yes Yes No No Yes TUB2; KRT12; 02/11/2017 Links
Haloperidol Psychotic disorders Yes Yes Yes Yes No No No No DRD2; DRD1; GRIN2B; HTR2A; DRD3; MCHR1; SLC18A2; HTR2C; SIGMAR1; HRH1; CHRM3; ADRA1A; ADRA2A; ADRA2B; ADRA2C; HTR1A; HTR6; HTR7; 06/11/2017 Links
HPV vaccine Human Papillomavirus vaccine, Papillomavirus vaccine Prevention of HPV-induced premalignant genital lesions Yes N/A No No Yes Yes Yes Yes 24/06/2021 Links
Hydralazine Hypertension Yes Yes Yes Yes No No Yes Yes AOC3; P4HA1; HIF1A; 07/11/2017 Links
Hydroxychloroquine Malaria Yes Yes Yes Yes Yes No Yes Yes TLR7; TLR9; ACE2; 04/01/2018 Links
Hymecromone Antispasmodic No Yes Yes Yes No No Yes Yes assT; 07/11/2017 Links
Ibandronic Acid Ibandronate Osteoporosis No Yes Yes Yes Yes No Yes Yes FDPS; GGPS1; 09/08/2021 Links
Ibudilast Multiple sclerosis, asthma, cerebrovascular disease No Yes Yes Yes No No Yes Yes PDE4A; PDE4B; PDE4C; PDE4D; PDE3A; 18/02/2020 Links
Ibuprofen Analgesia Yes Yes Yes Yes No No Yes Yes PTGS2; PTGS1; BCL2; THBD; FABP2; PPARG; CFTR; PPARA; GP1BA; S100A7; 07/11/2017 Links
Idebenone Leber's Hereditary Optic Neuropathy No No Yes No No No No No 19/03/2019 Links
Imipramine Depression No Yes Yes Yes No No Yes Yes SLC6A2; HTR2A; SLC6A4; HRH1; ADRA1A; ADRA1D; CHRM1; CHRM2; CHRM3; CHRM4; CHRM5; KCND2; KCND3; HTR2C; ADRA1B; HTR7; DRD1; DRD2; KCNH2; SLC6A3; HTR1A; HTR6; KCNH1; ORM2; 07/11/2017 Links
Indinavir Anti-retroviral No Yes Yes Yes No No Yes Yes pol; 29/06/2020 Links
Indomethacin Indometacin Analgesia No Yes Yes Yes Yes No Yes Yes PTGS1; PTGS2; PLA2G2A; PTGR2; PPARG; GLO1; PTGDR2; PPARA; AKR1C3; 20/11/2017 Links
Influenza vaccine Flu vaccine, influenzavirus vaccine Active immunization against flu infection Yes N/A Yes Yes No Yes Yes Yes 24/06/2021 Links
Irbesartan Hypertension No Yes Yes Yes Yes Yes No Yes AGTR1; JUN; 20/11/2017 Links
Itraconazole Fungal infections Yes Yes Yes Yes Yes Yes Yes Yes CYP51A1; ERG11; 20/11/2017 Links
Ivermectin Parasitic infection Yes Yes Yes Yes No No Yes Yes GLRA3; GABRB3; 09/06/2017 Links
Ketamine Anesthetic Yes Yes Yes Yes No No Yes Yes GRIN3A; TACR1; DRD2; OPRD1; SLC6A2; OPRK1; OPRM1; CHRM1; HTR2A; HTR1A; HTR3A; CHRNA7; BCHE; NOS1; 09/08/2018 Links
Ketoconazole Fungal infections No Yes Yes Yes Yes Yes Yes Yes ERG11; AR; CYP17A1; CYP21A2; KCNH2; NR1I2; NR1I3; 27/11/2017 Links
Ketoprofen Analgesia No Yes Yes Yes No No No No PTGS1; PTGS2; CXCR1; 19/03/2019 Links
Ketorolac Post-operative analgesia No Yes Yes Yes Yes Yes Yes Yes PTGS2; PTGS1; 29/11/2017 Links
Lamotrigine Epilepsy Yes Yes Yes Yes No No No No CACNA1E; SCN1A; ADORA1; ADORA2A; ADRA1A; ADRA2A; ADRB1; DRD1; DRD2; GABRA1; GABRA1; HRH1; OPRK1; CHRNA1; HTR2A; HTR3A; GRIA1; 12/03/2018 Links
Lansoprazole Antacid No Yes Yes Yes No Yes Yes Yes ATP4A; MAPT; 09/08/2021 Links
L-Arginine Nutraceutical No Yes Yes Yes No No Yes Yes 03/08/2021 Links
Leflunomide Arthritis No Yes Yes Yes No No Yes Yes DHODH; AHR; PTK2B; 17/02/2020 Links
Levamisole Parasitic infection Yes Yes Yes Yes Yes No Yes Yes CHRNA3; ALPPL2; unc-38; unc-63; lev-1; unc-29; 22/01/2019 Links
Levetiracetam Epilepsy No Yes Yes Yes Yes Yes Yes Yes SV2A; CACNA1B; 17/08/2021 Links
Levofloxacin Antibiotic Yes Yes Yes Yes Yes No No Yes parC; gyrA; 05/12/2017 Links
Levonorgestrel Contraceptive Yes Yes Yes Yes Yes Yes Yes Yes PGR; SRD5A1; ESR1; AR; SHBG; NR3C1; 09/08/2018 Links
L-Glutamine Nutraceutical No Yes Yes Yes No No Yes Yes CTPS1; PPAT; GLUL; 01/11/2017 Links
Lidocaine Anesthetic Yes Yes Yes Yes No No Yes Yes SCN10A; SCN9A; SCN5A; EGFR; SCN4A; ORM1; ORM2; 06/12/2017 Links
Liothyronine Hypothyroidism No Yes Yes Yes Yes Yes Yes Yes THRA; THRB; PCNA; 18/11/2020 Links
Liraglutide Diabetes No No Yes No No No No No GLP1R; 22/01/2019 Links
Lithium Bipolar disorders No Yes Yes Yes Yes No Yes Yes 06/12/2017 Links
Loperamide Diarrhea Yes Yes Yes No No No No No OPRM1; OPRD1; OPRK1; CACNA1A; POMC; CALM1; NR1I3; 07/12/2017 Links
Lopinavir Anti-retroviral Yes Yes Yes Yes No No Yes Yes pol; 29/01/2018 Links
Loratadine Allergies Yes Yes Yes No No Yes No Yes HRH1; KCNH2; 07/12/2017 Links
Losartan Hypertension Yes Yes Yes Yes No Yes Yes Yes AGTR1; 09/08/2021 Links
Lovastatin Hyperlipidemia Yes Yes Yes Yes Yes No Yes Yes HMGCR; ITGAL; HDAC2; 11/12/2017 Links
Loxoprofen Analgesia No Yes Yes Yes Yes Yes No Yes PTGS2; PTGS1; 11/12/2017 Links
Macitentan Pulmonary arterial hypertension No No Yes Yes No No Yes Yes EDNRA; EDNRB; 11/12/2017 Links
Manidipine Hypertension No Yes Yes Yes No No No No CACNA1C; CACNA1G; 11/12/2017 Links
Maraviroc Anti-retroviral No No Yes Yes No No Yes Yes CCR5; 10/06/2017 Links
Measles vaccine MMR vaccine Active immunization against measles infection Yes N/A Yes Yes No Yes Yes Yes 24/06/2021 Links
Mebendazole Parasitic infection Yes Yes Yes Yes Yes No Yes Yes TUBA1A; TUBB4B; 09/08/2021 Links
Meclizine Meclozine Antiemetic No Yes Yes No No No Yes Yes HRH1; NR1I3; 21/08/2019 Links
Meclofenamate Meclofenamic Acid Analgesia No Yes Yes Yes No No Yes Yes PTGS1; PTGS2; ALOX5; KCNQ2; KCNQ3; 12/12/2017 Links
Mefenamic Acid RA, OA, analgesia No Yes Yes Yes No No No No PTGS2; PTGS1; 02/03/2020 Links
Mefloquine Malaria Yes Yes Yes Yes No No Yes Yes ADORA2A; 09/08/2021 Links
Megestrol Acetate Hormone No Yes Yes Yes Yes No Yes Yes PGR; NR3C1; 12/12/2017 Links
Melatonin Insomnia No Yes Yes Yes Yes No Yes Yes MTNR1A; MTNR1B; ESR1; RORB; CALM1; MPO; EPX; CALR; ASMT; NQO2; 13/12/2017 Links
Meloxicam Analgesia No Yes Yes Yes Yes No Yes Yes PTGS2; PTGS1; 15/12/2017 Links
Memantine Alzheimer's Disease No Yes Yes No No No Yes Yes HTR3A; CHRNA7; DRD2; GRIN1; GRIN1; GABRA1; GLRA1; 04/01/2018 Links
Menadione Vitamin K3 Reversal of major bleeding after Warfarin No Yes Yes Yes No No Yes Yes GGCX; VKORC1; VKORC1L1; F2; F9; PROC; PROS1; NQO2; NQO1; BGLAP; 27/07/2020 Links
Menatetrenone Menaquinone-4, MK-4 Osteoporosis No Unclear Yes Yes Yes No Yes Yes 25/02/2020 Links
Mepacrine Quinacrine Parasitic infection No Yes Yes Yes No No Yes Yes PLA2G6; PLA2G4A; PLCL1; 04/01/2018 Links
Mepyramine Allergies No Yes Yes Yes No No No No HRH1; 20/03/2019 Links
Mesalazine Mesalamine, 5-aminosalicylic acid Inflammatory bowel disease Yes Yes Yes Yes No No Yes Yes PTGS2; PTGS1; ALOX5; PPARG; CHUK; IKBKB; MPO; nat; 18/08/2021 Links
Metformin Diabetes Yes Yes Yes Yes Yes Yes Yes Yes PRKAB1; ETFDH; GPD1; 15/12/2017 Links
Methazolamide Antiglaucoma, diuretic No Yes No No No No Yes Yes CA1; CA4; CA2; CA7; CA3; 15/12/2017 Links
Methimazole Thiamazole Hyperthyroidism Yes Yes No No Yes No Yes Yes TPO; 15/12/2017 Links
Methylene Blue Methylthioninium chloride Methemoglobinemia, cyanide toxicity No Yes Yes Yes No No Yes Yes GUCY1A2; NOS1; 26/03/2019 Links
Methylnaltrexone Opioid-induced constipation No Yes Yes Yes No Yes No Yes OPRM1; OPRK1; 09/08/2021 Links
Metoclopramide Anti-emesis Yes Yes Yes Yes No No Yes Yes DRD2; CHRM1; HTR4; HTR3A; 18/12/2017 Links
Metronidazole Bacterial infection Yes Yes Yes Yes No No Yes Yes rdxA; 07/09/2020 Links
Metyrapone Adrenal insufficiency, Cushing's syndrome No Yes No Yes Yes No No Yes CYP11B1; camC; 11/03/2020 Links
Miconazole Fungal infections Yes Yes Yes Yes No No Yes Yes ERG11; NOS3; NOS2; NR1I2; KCNMA1; KCNA1; KCNJ12; CACNA1C; 13/08/2019 Links
Midazolam Sedation Yes Yes Yes Yes No No No No GABRA1; GABRA1; 12/03/2018 Links
Mifepristone Abortifacient No Yes Yes Yes Yes No Yes Yes PGR; NR3C1; KLK3; NR1I2; 19/12/2017 Links
Miltefosine Hexadecylphosphocholine Leishmaniasis Yes Yes Yes Yes Yes No Yes Yes ABCB1; 17/02/2020 Links
Minocycline Antibiotic No Yes Yes Yes No No Yes Yes rpsI; rpsD; IL1B; ALOX5; MMP9; VEGFA; CASP1; CASP3; CYCS; MAPK1; NOS2; 20/12/2017 Links
Minoxidil Antihypertensive, alopecia No Yes Yes Yes No No No No KCNJ1; PTGS1; REN; 23/06/2020 Links
Mirtazapine Depression No Yes Yes Yes No No No No HTR2A; ADRA2A; HTR2C; OPRK1; HRH1; ADRA1A; 20/12/2017 Links
Mometasone Mometasone furoate Asthma prophylaxis No Yes Yes No No No No No NR3C1; PGR; 15/02/2018 Links
Montelukast Allergies No Yes Yes Yes No No No No CYSLTR1; ALOX5; 20/12/2017 Links
Mumps vaccine MMR vaccine Active immunization against mumps infection Yes N/A Yes Yes No No No No 24/06/2021 Links
Mycophenolate Mycophenolic acid Immunosuppressant No Yes Yes Yes Yes No Yes Yes IMPDH1; IMPDH2; 09/08/2021 Links
Nadroparin Prophylaxis of venous thromboembolism Yes Yes Yes Yes No Yes Yes Yes SERPINC1; SELP; FOS; MYC; 09/08/2021 Links
Naftopidil Benign prostatic hyperplasia No Unclear Yes Yes Yes Yes Yes Yes 06/02/2018 Links
Naltrexone Opioid receptor antagonist No Yes Yes Yes Yes No Yes Yes OPRD1; OPRM1; OPRK1; SIGMAR1; 03/01/2018 Links
Naproxen Analgesia No Yes Yes Yes Yes No Yes Yes PTGS1; pab; PTGS2; 03/01/2018 Links
Nelfinavir Anti-retroviral No Yes Yes Yes Yes No Yes Yes HIV-1 protease; 09/08/2021 Links
Nicardipine Hypertension, angina pectoris No Yes Yes Yes Yes No Yes Yes CACNA1C; CACNB2; CACNA2D1; CACNA1D; PDE1A; PDE1B; ADRA1A; ADRA1B; ADRA1D; CHRM1; CHRM2; CHRM3; CHRM4; CHRM5; CALM1; 17/03/2021 Links
Niclosamide Parasitic infection Yes Yes Yes Yes No No Yes Yes 09/08/2021 Links
Nicotinamide Niacinamide Niacin Deficiency, Skin cancer chemoprevention Yes Yes Yes Yes No No Yes Yes eta; LDHA; PARP1; SIRT5; BST1; 01/03/2018 Links
Nifedipine Hypertension Yes Yes Yes Yes Yes No Yes Yes CACNA1C; NR1I2; CALM1; CACNA1D; CACNA1S; CACNB2; KCND3; CACNA1G; 03/01/2018 Links
Nifuroxazide Colitis, acute diarrhea No Yes Yes Yes No No No No 26/06/2019 Links
Nifurtimox Chagas disease, African sleeping sickness Yes Unclear Yes Yes Yes No Yes Yes 03/01/2018 Links
Nimesulide Analgesia No Yes Yes Yes No No Yes Yes PTGS2; PLA2G2E; LTF; 19/12/2018 Links
Nimodipine Hypertension No Yes Yes Yes No No No No CACNA1C; CACNA1D; CACNA1F; CACNA1S; CACNB1; CACNB2; CACNB3; CACNB4; NR3C2; AHR; 04/01/2018 Links
Nisoldipine Hypertension No Yes Yes Yes No No No No CACNA1C; CACNA2D1; CACNB2; CACNA1D; CACNA1S; 04/01/2018 Links
Nitazoxanide Anti-protozoal No Yes Yes Yes No No Yes Yes por; 09/08/2021 Links
Nitisinone Hereditary tyrosinemia type 1 No Yes No No Yes No No Yes HPD; 09/08/2021 Links
Nitroglycerin Glyceryl trinitrate Nitro-vasodilator Yes Yes Yes Yes Yes No Yes Yes NPR1; 04/01/2018 Links
Nitroxoline Antibiotic No Yes Yes Yes No No Yes Yes METAP2; 04/01/2018 Links
Norethandrolone Aplastic anemia No Yes Yes Yes No No Yes Yes 23/08/2017 Links
Noscapine Anti-tussive No Yes Yes Yes No No Yes Yes SIGMAR1; 04/01/2018 Links
Obeticholic Acid Primary biliary cholangitis No No Yes Yes No No No No NR1H4; 20/03/2019 Links
Olanzapine Psychotic disorders No Yes Yes Yes No No No No HTR2A; DRD2; DRD1; DRD5; DRD3; DRD4; HTR2C; HTR3A; HTR6; HRH1; ADRA1A; ADRA1B; CHRM1; CHRM2; CHRM3; CHRM4; DRD1; ADRB1; HTR1A; GABRA1; 30/10/2017 Links
Olmesartan Hypertension No Yes Yes Yes No No No No AGTR1; 21/02/2018 Links
Olsalazine Rheumatoid arthritis; ulcerative colitis; active Crohn's Disease. No Yes Yes Yes No No No No TPMT; IFNG; 08/01/2018 Links
Omega 3 Lovaza, Fish Oil, Omacor, eicosapentaenoic acid, docosahexaenoic acid Hyperlipidemia No Unclear Yes Yes Yes Yes Yes Yes DGAT2; PTGS2; FFAR4; CACNA1C; SCN1A; NFKB2; SREBF1; PPARA; PPARG; PPARD; 31/01/2018 Links
Omeprazole Antacid Yes Yes Yes Yes Yes No Yes Yes ATP4A; AHR; 08/01/2018 Links
Orlistat Obesity No Yes Yes Yes No No No No PNLIP; LIPF; FASN; 02/10/2017 Links
Ormeloxifene Contraceptive No Yes Yes Yes No No No No 09/01/2018 Links
Oseltamivir Anti-viral Yes Yes Yes Yes No No No No NA; NEU1; NEU2; 09/01/2018 Links
Ospemifene Vulvar and vaginal atrophy No No Yes Yes No No No No ESR1; 19/01/2021 Links
Ouabain Cardiac arrhythmia No Yes Yes Yes No No No No ATP1A1; ATP1A2; ATP1A3; 10/01/2018 Links
Oxcarbazepine Epilepsy No Yes Yes No No Yes No Yes SCN1A; 12/06/2017 Links
Pamidronic Acid Pamidronate Osteoporosis No Yes Yes Yes Yes No Yes Yes FDPS; GGPS1; CASP3; CASP9; 06/02/2018 Links
Pantoprazole Antacid No Yes Yes Yes Yes Yes Yes Yes ATP4A; DDAH1; 10/01/2018 Links
Parecoxib Post-operative analgesia No Yes Yes Yes No No Yes Yes PTGS2; LTF; 24/09/2018 Links
Paricalcitol Vitamin D2 Hyperparathyroidism No Yes Yes Yes Yes No Yes Yes VDR; 09/08/2018 Links
Paroxetine Depression No Yes Yes Yes No No No No SLC6A4; SLC6A2; HTR2A; ADRA1A; ADRA2A; ADRB1; DRD2; HRH1; HTR1A; CHRM1; HTR2B; DRD1; 19/12/2018 Links
Penfluridol Psychotic disorders No Yes Yes Yes No No No No 11/01/2018 Links
Pentamidine Parasitic infection Yes Yes Yes Yes No No Yes Yes TRDMT1; 11/01/2018 Links
Pentoxifylline Peripheral artery disease No Yes Yes Yes No No Yes Yes ADORA1; ADORA2A; NT5E; 15/01/2018 Links
Perampanel Epilepsy No No Yes No No Yes No Yes GRIA1; 03/02/2021 Links
Perphenazine Psychotic disorders No Yes Yes Yes No No No No DRD2; DRD1; CALM1; 15/01/2018 Links
Pertussis vaccine DTP vaccine Active immunization against pertussis infection Yes N/A Yes Yes Yes No No Yes 24/06/2021 Links
Phenelzine Depression No Yes Yes Yes No No Yes Yes MAOA; MAOB; AOC3; ABAT; GPT; GPT2; GAD65; 04/03/2020 Links
Phenoxybenzamine Pheochromocytoma No Yes Yes Yes No No No No ADRA1A; ADRA2A; ADRA2C; ADRA2B; CALM1; ADRB2; ADRA1B; ADRA1D; 09/08/2018 Links
Phentolamine Vasodilator No Yes Yes Yes No No No No ADRA2A; ADRA1A; ADRA1B; ADRA1D; 17/01/2018 Links
Phenylbutyrate Glycerol Phenylbutyrate Urea cycle disorders No Unclear Yes Yes Yes No Yes Yes 17/01/2018 Links
Phenytoin Epilepsy Yes Yes Yes Yes No No Yes Yes SCN5A; SCN1A; NR1I2; SCN1B; SCN3A; KCNH2; CACNA1C; SCN2A; SCN8A; GABRA1; 09/08/2021 Links
Pimozide Psychotic disorders No Yes Yes Yes Yes No No Yes DRD2; DRD3; KCNH2; CALM1; 18/01/2018 Links
Pioglitazone Diabetes No Yes Yes Yes Yes No Yes Yes PPARG; MAOB; 18/01/2018 Links
Pirfenidone Anti-fibrotic No No Yes Yes No No Yes Yes 18/01/2018 Links
Piroxicam Analgesia No Yes Yes Yes Yes No Yes Yes PTGS2; PTGS1; 22/05/2018 Links
Plerixafor AMD3100 Autologous HSCT No Yes Yes Yes Yes No Yes Yes CXCR4; 09/08/2021 Links
Pneumococcal vaccine Pneumococcus vaccine, streptococcus pneumoniae vaccine Active immunization against pneumococcal infection Yes N/A No No No No Yes Yes 24/06/2021 Links
Posaconazole Fungal infections No Yes Yes Yes No No Yes Yes ERG11; 19/12/2018 Links
Pravastatin Hyperlipidemia Yes Yes Yes Yes No Yes Yes Yes HMGCR; HDAC2; 22/01/2018 Links
Prazosin Hypertension No Yes Yes Yes No No No No ADRA1A; ADRA1B; ADRA1D; KCNH2; ADRA2A; ADRA2B; ADRA1A; 22/01/2018 Links
Prochlorperazine Prochlorperazine dimaleate Psychotic disorders No Yes Yes Yes No No Yes Yes DRD2; HRH1; ADRA1A; ADRA2A; 15/02/2018 Links
Promethazine Psychotic disorders No Yes Yes Yes No No No No HRH1; DRD2; CHRM1; CHRM2; CHRM3; CHRM4; CHRM5; ADRA1A; CALM1; HRH2; LPAR4; SCN1A; KCNA1; 22/01/2018 Links
Propafenone Anti-arryhtmic No Yes Yes Yes No No No No SCN5A; KCNH2; ADRB1; ADRB2; 22/01/2018 Links
Propofol Anesthetic Yes Yes Yes Yes No Yes Yes Yes GABRB2; GABRB3; SCN4A; SCN2A; GABRA1; 10/02/2021 Links
Propranolol Hypertension Yes Yes Yes Yes Yes Yes Yes Yes ADRB1; ADRB2; ADRB3; HTR1A; HTR1B; 22/01/2018 Links
Pyridoxine Vitamin B6 Vitamin B6 deficiency Yes Yes Yes Yes No No Yes Yes PDXK; 14/08/2018 Links
Pyrimethamine Parasitic infection Yes Yes Yes Yes Yes No Yes Yes DHFR; HEXB; 10/08/2021 Links
Pyronaridine Malaria No Yes Yes Yes No No No No 11/05/2020 Links
Pyrvinium Pamoate Pyrvinium Parasitic infection No Yes Yes Yes No No No No 23/01/2018 Links
Quetiapine Psychotic disorders No Yes Yes No No No No No HTR2A; DRD2; HTR1A; HTR1B; HTR1D; HTR1E; HTR2C; HTR3A; HTR6; HTR7; DRD1; DRD5; DRD3; DRD4; HRH1; ADRA1A; ADRA2A; ADRA2B; ADRA2C; CHRM1; CHRM2; CHRM3; CHRM4; CHRM5; 23/01/2018 Links
Rabeprazole Antacid No Yes Yes Yes No No Yes Yes ATP4A; 25/01/2018 Links
Raloxifene Osteoporosis No Yes Yes Yes No Yes Yes Yes ESR1; ESR2; SERPINB9; TFF1; 23/11/2020 Links
Ranitidine Antacid Yes Yes Yes Yes Yes No Yes Yes HRH2; ACHE; 02/11/2017 Links
Ranolazine Anti-angina No Yes Yes Yes No No No No SCN1A; KCNJ12; CACNA1C; ADRA1A; ADRB1; 10/08/2021 Links
Repaglinide Diabetes No Yes Yes Yes No No No No ABCC8; PPARG; 10/08/2021 Links
Reserpine Hypertension, anti-psychotic No Yes Yes Yes No No No No SLC18A2; SLC18A1; BIRC5; 22/01/2019 Links
Ribavirin Anti-viral Yes Yes Yes Yes Yes No Yes Yes IMPDH1; IMPDH2; L; PB1; 16/06/2017 Links
Rifabutin Antibiotic Yes Yes Yes No No No No No rpoA; rpoB; rpoC; HSP90AA1; HSP90B1; 29/01/2018 Links
Rifampicin Rifampin Tuberculosis Yes Yes Yes Yes Yes No No Yes rpoB; NR1I2; 04/04/2019 Links
Riluzole ALS No Yes Yes Yes No No Yes Yes SCN5A; SLC7A11; 29/01/2018 Links
Risedronic Acid Risedronate Osteoporosis, prophylaxis of skeletal fractures, Paget's disease No Yes Yes Yes No No Yes Yes FDPS; 13/09/2018 Links
Risperidone Psychotic disorders Yes Yes Yes Yes No No No No HTR2A; DRD2; ADRA1B; ADRA2B; ADRA1A; ADRA2C; HRH1; HTR2C; HTR1D; HTR1A; HTR7; DRD1; 29/01/2018 Links
Ritonavir Anti-retroviral Yes Yes Yes Yes Yes No Yes Yes pol; NR1I2; 10/08/2021 Links
Roflumilast COPD No Yes Yes Yes No No Yes Yes PDE4D; PDE4A; PDE4B; PDE4C; 10/08/2021 Links
Rosiglitazone Diabetes No Yes Yes Yes Yes No Yes Yes PPARG; ACSL4; PPARA; PPARD; RXRA; RXRB; RXRG; 18/03/2021 Links
Rosuvastatin Hyperlipidemia No Yes Yes Yes No No Yes Yes HMGCR; ITGAL; 30/01/2018 Links
Rotavirus vaccine Active immunization against rotavirus infection Yes N/A Yes Yes No No No No 24/06/2021 Links
Roxatidine Antacid No Yes Yes Yes No No No No 17/02/2020 Links
Roxithromycin Bacterial infections No Yes Yes Yes Yes No No Yes rplJ; ABCB1; 14/05/2018 Links
Sertraline Depression No Yes Yes Yes No No Yes Yes SLC6A4; SLC6A3; PGRMC1; SLC6A2; SLC29A4; 29/01/2018 Links
Sildenafil Erectile dysfunction No Yes Yes Yes Yes No Yes Yes PDE5A; PDE6G; PDE6H; 29/01/2018 Links
Simvastatin Hyperlipidemia Yes Yes Yes Yes No Yes Yes Yes HMGCR; ITGAL; HDAC2; 30/01/2018 Links
Sirolimus Rapamycin Inhibit organ transplant rejection No Yes Yes Yes Yes No Yes Yes MTOR; FKBP1A; FGF2; 31/01/2018 Links
Sitagliptin Diabetes No No Yes Yes No Yes Yes Yes DPP4; 19/01/2021 Links
Smallpox vaccine Active immunization against smallpox infection No N/A No No No Yes Yes Yes 24/06/2021 Links
Sodium Aurothiomalate Active progressive rheumatoid arthritis No Yes Yes Yes No No Yes Yes 12/03/2018 Links
Sodium Bicarbonate Relief of wind and griping pains No Yes Yes Yes Yes No Yes Yes 30/01/2018 Links
Spironolactone Congestive cardiac failure, Hepatic cirrhosis with ascites and oedema, Malignant ascites, Nephrotic syndrome, Diagnosis and treatment of primary aldosteronism. Yes Yes Yes Yes No No Yes Yes NR3C2; AR; PGR; NR3C1; CYP11B2; CYP17A1; SRD5A1; SHBG; CACNG1; NR1I2; 09/11/2017 Links
Sulfasalazine Rheumatoid arthritis; ulcerative colitis; active Crohn's Disease. Yes Yes Yes Yes Yes No Yes Yes ALOX5; PTGS2; PTGS1; PPARG; CHUK; IKBKB; SLC7A11; ACAT1; TBXAS1; PLA2G1B; 09/11/2017 Links
Sulindac Relief of signs and symptoms of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute painful shoulder (acute subacromial bursitis/supraspinatus tendinitis), and acute gouty arthritis. No Yes Yes Yes No Yes Yes Yes PTGS2; PTGS1; AKR1B1; MAPK3; PPARD; PTGDR2; AKR1B10; 09/11/2017 Links
Suramin African sleeping sickness No Unclear Yes Yes Yes No Yes Yes P2RY2; SIRT5; FSHR; RYR1; F2; PLA2G2A; 19/03/2019 Links
Tacalcitol Plaque psoriasis No Unclear Yes Yes No No No No 19/03/2020 Links
Tadalafil Erectile dysfunction No Yes Yes Yes No No Yes Yes PDE5A; PDE11A; 09/11/2017 Links
Tegaserod IBS with constipation No Yes Yes Yes No No No No HTR4; HTR2B; HTR2C; HTR2A; 10/09/2020 Links
Telmisartan Hypertension, cardiovascular prevention Yes Yes Yes Yes No Yes No Yes AGTR1; PPARG; 09/11/2017 Links
Terbinafine Treatment of tinea pedis (athlete's foot), tinea cruris (dhobie (jock) itch) and tinea corporis (ringworm) Yes Yes Yes Yes No No Yes Yes ERG1; SQLE; 09/11/2017 Links
Teriflunomide Relapsing multiple sclerosis No Yes Yes Yes No No No No DHODH; 17/02/2020 Links
Tetanus vaccine Tetanus toxoid, DTP vaccine, DT vaccine, Td vaccine Active immunization against tetanus infection Yes N/A Yes Yes Yes Yes Yes Yes 24/06/2021 Links
Thiabendazole Parasitic infection No Unclear Yes Yes No No No No frdA; 09/11/2017 Links
Thioridazine Psychotic disorders No Yes Yes Yes Yes No Yes Yes DRD2; DRD1; ADRA1A; ADRA1B; HTR2A; KCNH2; 09/08/2021 Links
Ticagrelor Prevention of atherothrombotic events in combo with ASA No Yes Yes Yes No No Yes Yes P2RY12; 09/08/2021 Links
Ticlopidine Prevent strokes, blood loss No Yes Yes Yes Yes No Yes Yes P2RY12; 09/11/2017 Links
Tigecycline Infections No Yes Yes Yes No No Yes Yes rpsI; rpsL; rpsM; rpsN; rpsS; 09/08/2021 Links
Timolol Hypertension, ischemic heart disease, migraine Yes Yes Yes Yes Yes Yes Yes Yes ADRB1; ADRB2; E; 09/08/2021 Links
Tinzaparin Prophylaxis of venous thromboembolism No No Yes Yes No No Yes Yes SERPINC1; ITGA4; CXCL12; 03/11/2017 Links
Tioconazole Parasitic infection No Yes Yes Yes No No No No ERG11; CYP51A1; 23/01/2018 Links
Tocilizumab Rheumatoid arthritis No Yes Yes Yes No No Yes Yes IL6R; 10/08/2021 Links
Tofacitinib Rheumatoid arthritis No No Yes Yes Yes No Yes Yes JAK1; JAK2; JAK3; TYK2; 10/08/2021 Links
Tolfenamic Acid Tolfenamate Migraine No Yes Yes Yes No No No No PTGS1; PTGS2; 03/11/2017 Links
Topiramate Epilepsy (tonic clonic seizure) No Yes Yes Yes No No No No GABRA1; SCN1A; GRIK1; CA2; CA4; CA1; CA3; CACNA1C; CACNA1E; 12/06/2017 Links
Tranexamic Acid Blood loss - fibrinolysis Yes Yes Yes Yes Yes No Yes Yes PLG; 03/11/2017 Links
Tranilast Bronchial asthma No Yes Yes Yes No No Yes Yes HPGDS; 02/03/2020 Links
Tranylcypromine Depression No Yes Yes Yes No No Yes Yes MAOB; MAOA; 13/08/2021 Links
Trazodone Depression, anxiety No No Yes Yes No No No No HTR2A; HTR2C; SLC6A4; HTR1A; HRH1; ADRA1A; ADRA2A; Htr2c; 03/11/2017 Links
Triamterene Diuretic, oedema in cardiac failure, cirrhosis of the liver or the nephrotic syndrome, and in that associated with corticosteroid treatment No Yes Yes Yes No No No No SCNN1G; SCNN1A; SCNN1B; SCNN1D; 03/11/2017 Links
Trientine Triethylenetetramine Wilson's disease No Yes Yes Yes No No Yes Yes 23/06/2021 Links
Trifluoperazine Psychotic disorders No Yes Yes Yes No No Yes Yes DRD2; CALY; ADRA1A; CALM1; TNNC1; S100A4; 17/08/2021 Links
Trimebutine Irritable bowel syndrome No Unclear Yes Yes No No No No OPRM1; CACNA1C; KCNMA1; CACNA1G; CHRM1; CHRM2; CHRM3; CHRM4; 01/09/2021 Links
Trimetazidine Angina pectoris No Yes Yes Yes No No Yes Yes ACAA1; 09/08/2018 Links
Typhoid vaccine Typhoid paratyphoid vaccine, paratyphoid vaccine Active immunization against typhoid infection Yes N/A Yes Yes No No Yes Yes 24/06/2021 Links
Ulinastatin Severe sepsis & pancreatitis No Unclear Yes Yes No No Yes Yes 03/11/2017 Links
Ursodeoxycholic Acid UCDA, Ursodiol Gallstones, primary biliary cirrhosis No Yes Yes Yes No Yes Yes Yes AKR1C2; NR1H4; 28/08/2019 Links
Valganciclovir Cytomegalovirus in HIV/AIDS Yes Yes No Yes Yes Yes Yes Yes 29/07/2020 Links
Valproic Acid Valproate Epilepsy Yes Yes Yes Yes Yes Yes Yes Yes ACADSB; HDAC9; OGDH; ALDH5A1; SCN1A; HDAC2; PPARA; PPARD; PPARG; 03/11/2017 Links
Valsartan Hypertension, myocardial infarction, heart failure No Yes Yes Yes No Yes No Yes AGTR1; 03/11/2017 Links
Vardenafil Erectile dysfunction No Yes Yes Yes No No Yes Yes PDE5A; PDE6G; PDE6H; 09/08/2021 Links
Varicella vaccine Chickenpox vaccine, VZV vaccine, shingles vaccine, HHV-3 vaccine, HHV3 vaccine Active immunization against VZV infection Yes N/A No No No No Yes Yes 24/06/2021 Links
Verapamil Hypertension, angina pectoris Yes Yes Yes Yes Yes Yes Yes Yes CACNA1C; CACNA1B; CACNA1A; KCNJ11; CACNA1G; CACNA1H; KCNH2; SLC6A4; ADRA1A; ADRA1B; ADRA1D; 09/08/2021 Links
Verteporfin Exudative age-related macular degeneration No No Yes Yes Yes No Yes Yes 09/08/2018 Links
Warfarin Prophylaxis of systemic embolism, of venous thrombosis and pulmonary embolism. Yes Yes Yes Yes No Yes Yes Yes VKORC1; NR1I2; 04/01/2018 Links
Yellow Fever vaccine Active immunization against yellow fever infection Yes N/A Yes Yes No Yes No Yes 24/06/2021 Links
Zidovudine Azidothymidine Anti-retroviral Yes Yes Yes Yes Yes No Yes Yes pol; TERT; 22/02/2018 Links
Zileuton Asthma prophylaxis No Yes Yes Yes No No Yes Yes ALOX5; 22/01/2019 Links
Zoledronic Acid Zoledronate Osteoporosis, prophylaxis of skeletal fractures and treat hypercalcemia of malignancy, treat pain from bone metastases Yes Yes Yes Yes Yes Yes Yes Yes FDPS; GGPS1; 03/11/2017 Links