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Drug repurposing candidates in the treatment of brain metastases

Presented during the 10th edition of Brain Metastases Research and Emerging Therapy Conference

10 drugs in 1 trial: an unconventional way to fight brain cancer

A phase Ib/IIa trial of 9 repurposed drugs combined with temozolomide for the treatment of recurrent glioblastoma: CUSP9v3

Marc-Eric Halatsch, Richard E. Kast, Georg Karpel-Massler, Benjamin Mayer, Oliver Zolk, Bernd Schmitz, Angelika Scheuerle, Ludwig Maier, Lars Bullinger, Regine Mayer-Steinacker, Carl Schmidt, Katharina Zeiler, Ziad Elshaer, Patricia Panther, Birgit Schmelzle, Anke Hallmen, Annika Dwucet, Markus D. Siegelin, Mike-Andrew Westhoff, Kristine Beckers, Gauthier Bouche, and Tim Heiland. A phase Ib/IIa trial of 9 repurposed drugs combined with temozolomide for the treatment of recurrent glioblastoma: CUSP9v3. Neuro-Oncology Advances, 3(1), 1–11, 2021, doi.org/10.1093/noajnl/vdab075

Discovery and 3D imaging of a novel ΔNp63- expressing basal cell type in human pancreatic ducts with implications in disease

Sandrina Martens, Katarina Coolens, Mathias Van Bulck, Tatjana Arsenijevic, Joan Casamitjana, Angel Fernandez Ruiz, Abdessamad El Kaoutari, Jaime Martinez de Villareal, Hediel Madhloum, Farzad Esni, Yves Heremans, Gunter Leuckx, Harry Heimberg, Luc Bouwens, Patrick Jacquemin, Diedert Luc De Paep, Peter in't Veld, Nicky D'Haene, Christelle Bouchart, Nelson Dusetti, Jean-Luc Van Laethem, Wim Waelput, Pierre Lefesvre, Francisco X Real, Meritxell Rovira, Ilse Rooman. Discovery and 3D imaging of a novel ΔNp63-expressing basal cell type in human pancreatic ducts with implications in disease. Gut 2021;0:1-13. doi: 10.1136/gutjnl-2020-322874

Use of non-cancer drugs and survival among patients with pancreatic adenocarcinoma: a nationwide registry-based study in Norway

Nathalie C Støer, Gauthier Bouche, Pan Pantziarka, Erica K Sloan, Bettina K Andreassen, Edoardo Botteri. Use of non-cancer drugs and survival among patients with pancreatic adenocarcinoma: a nationwide registry-based study in Norway. Acta Oncol., 2021 Aug 2;1-8. doi: 10.1080/0284186X.2021.1953136