Latest news on drug repurposing in oncology
Drug repurposing is a strategy for identifying new uses for approved drugs, outside the scope of the original indication. We have listed recent findings about the repurposing of drugs in oncology. Our intention is to bring these findings to the attention of the broader cancer research community.
Being listed in a newsletter is no endorsement of the results and conclusions of the article. All articles need to be critically assessed and viewed in their broader research context.
Please get in touch if you’re interested in discussing research based on the findings presented below (email@example.com).
Top story published in Nature: Tumour immune rejection triggered by activation of α2-adrenergic receptors.
Top story published in The Journal of Clinical Investigation: Canagliflozin primes antitumor immunity by triggering PD-L1 degradation in endocytic recycling
Top story published in Nature Cancer: A reversible SRC-relayed COX2 inflammatory program drives resistance to BRAF and EGFR inhibition in BRAFV600E colorectal tumors
Published in Medicine: Propofol-based total intravenous anesthesia is associated with better survival than desflurane anesthesia in limb-salvage surgery for osteosarcoma: A retrospective analysis
Published in Scientific Reports: Propranolol blocks osteosarcoma cell cycle progression, inhibits angiogenesis and slows xenograft growth in combination with cisplatin-based chemotherapy
Published in Cancer Treatment and Research Communications: Doxycycline inhibits the progression of metastases in early-stage osteosarcoma by downregulating the expression of MMPs, VEGF and ezrin at primary sites
Top story published in Jama: Effect of Metformin vs Placebo on Invasive Disease-Free Survival in Patients With Breast Cancer: The MA.32 Randomized Clinical Trial.
Published in Neuro Oncology: Anti-invasive efficacy and survival benefit of the YAP-TEAD inhibitor Verteporfin in preclinical glioblastoma models
Published in Science Advances: Polyamines drive myeloid cell survival by buffering intracellular pH to promote immunosuppression in glioblastoma
Top story published in Cancer Cells: Inflammatory fibroblasts mediate resistance to neoadjuvant therapy in rectal cancer
Top stories: three papers investigating the use of drug repurposing to improve the response to immune checkpoint inhibitors. In particular the use of the non-cancer drugs propranolol, mifepristone and tadalafil.
Top story published in Cancer Cell: The allergy mediator histamine confers resistance to immunotherapy in cancer patients via activation of the macrophage histamine receptor H1
Top story published in Science Advances: The metabolic adaptation evoked by arginine enhances the effect of radiation in brain metastases
Top story published in Clinical Cancer Research: Losartan blocks osteosarcoma-elicited monocyte recruitment, and combined with the kinase inhibitor toceranib, exerts significant clinical benefit in canine metastatic osteosarcoma
Top story published in Neuro-Oncology Advances: A phase Ib/IIa trial of 9 repurposed drugs combined with temozolomide for the treatment of recurrent glioblastoma: CUSP9v3
Top story published in Frontiers in Oncology: Repurposing Infectious Diseases Vaccines Against Cancer
Top story published in Blood Cancer: Lenalidomide and dexamethasone with or without clarithromycin in patients with multiple myeloma ineligible for autologous transplant: a randomized trial.
Top story published in Jama: Effect of Celecoxib vs Placebo Added to Standard Adjuvant Therapy on Disease-Free Survival Among Patients With Stage III Colon Cancer
Top story published in British Journal of Haematology: Indomethacin is an effective treatment in adults and children with bone Langerhans cell histiocytosis (LCH).
Top story published in Clinical Cancer Research: Mitochondrial Inhibitor Atovaquone Increases Tumor Oxygenation and Inhibits Hypoxic Gene Expression in Patients with Non-Small Cell Lung Cancer.
Top story published in Cancer Cell: Arsenic Trioxide Rescues Structural p53 Mutations through a Cryptic Allosteric Site.
Top story published in Pediatric Blood & Cancer: Metro-SMHOP 01: Metronomics combination with cyclophosphamide-etoposide and valproic acid for refractory and relapsing pediatric malignancies.
Top story published in Clinical Cancer Research, the official journal of the American Association for Cancer Research: Phase I clinical trial of combination propranolol and pembrolizumab in locally advanced and metastatic melanoma: Safety, Tolerability, and Preliminary Evidence of Antitumor Activity
Top story published in the British Journal of Surgery: Influence of Klebsiella pneumoniae and quinolone treatment on prognosis in patients with pancreatic cancer.