It is important to investigate the impacts of drugs beyond what they can achieve alone. Using them in combination can act as a multiplier and increase the sum of their benefits.
Achieving synergistic effects, fighting resistance
The complexity of cancer underscores the need for a variety of treatment approaches, which is why a combination of one or more therapeutic interventions is often used to battle cancer. Combination therapy might achieve efficacy with lower doses or less toxic drugs. It can chemo-sensitise cells, making an additional compound more potent. It can have additive or synergistic effects, minimise drug resistance, or fight against expected resistance. Although monotherapy is still a common approach, it is often deemed that even better results could potentially be obtained when these therapies will become rationally combined with others.
Targeting cancer’s escape route
Methods to eradicate cancer cells have evolved from surgery, radiotherapy and chemotherapy to therapies targeting the tumour micro-environment, such as immunotherapy. New insights into how we can influence, control and limit tumour growth leads to the potential of combination therapies. Combining several interventions attacks multiple tumour pathways at the same time, enhancing the overall impact on tumour growth.
Our trials in this focus area
Drug repurposing[in het Engels] Drug repurposing, also known as drug repositioning, is a drug development strategy predicated on the...
Minder vaak voorkomende en zeldzame kankers[in het Engels] We don’t just focus on the ‘big four’ of cancer – prostate, colon, breast and lung.
Combinatietherapieën[in het Engels] It is important to investigate the impacts of drugs beyond what they can achieve alone. Using them in...
Herval voorkomen[in het Engels] For cancer survivors, the fight isn’t always over. Many are concerned about the possibility of...