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Database repurposing drugs in oncology

ReDO_DB is a curated listing of non-cancer drugs which have shown some evidence of anticancer activity. Data comes from peer-reviewed studies, medical case reports, observational studies and clinical trials. All drugs are also checked whether they are included in the World Health Organisation Essential Medicines List and are available off-patent. Drugs highlighted are subjects of ReDO review papers, which can be accessed by clicking on the drug name.

Cite as: Pantziarka Pan, Verbaanderd Ciska, Sukhatme Vidula, Capistrano Rica, Crispino Sergio, Gyawali Bishal, Rooman Ilse, Van Nuffel An MT, Meheus Lydie, Sukhatme Vikas P and Bouche Gauthier (2018) ReDO_DB: the repurposing drugs in oncology database ecancer 12 886

A machine-readable version of this database can be downloaded here: ReDO_DB.txt.

Important note for patients! This list identifies drugs that, based on their scientific properties, warrant further scientific investigation. In most cases the existing scientific evidence for their effects on cancer is very limited. Further scientific and clinical research is needed before any statements regarding their anti-cancer activity can be made. This list is not intended to be used as a source for possible treatment options for patients.

If you need help exploring further treatment options for your situation, please take a look at our My Cancer Navigator service.

Summary results as of last build on: 02/10/24

NumberPercentageNumberPercentage
Total number of drugs included in ReDO database372100.0%Drugs with observational studies5715.3%
Drugs included in WHO EML11831.7%Drugs with clinical trials24465.6%
Drugs which are off-patent32487.1%Trials with published reports16266.4%
Drugs with in vitro evidence36197.0%Drugs for which human data exists26771.8%
Drugs with in vivo evidence34392.2%WHO + Off-patent + Human data8422.6%
Drugs with case(s) reports11230.1%Number of unique molecular targets1156-

Click in header cell to sort table by that column. Hover over header cell for additional text. Click on Links cell for additional resources

Database build date: 02/10/24

Number of drugs in database: 372 (Filter not active)


Drug Synonym Main Indications WHO Off-Patent Vitro Vivo Cases Obs. Trials Human Targets Date Update Links
Abacavir 1592U89 Anti-retroviral Yes Yes Yes No Yes No Yes Yes pol; HLA-B; 2021-10-25 Links
Acarbose Diabetes No Yes No Yes No No Yes Yes MGAM; SI; AMY2A; GAA; 2022-08-09 Links
Acetaminophen Paracetamol Analgesia Yes Yes Yes Yes Yes Yes Yes Yes PTGS2; PTGS1; PTGES3; TRPV1; 2017-07-13 Links
Acetazolamide Glaucoma, diuretic, epilepsy Yes Yes Yes Yes No No Yes Yes CA1; CA2; CA4; CA12; CA14; CA3; CA7; AQP1; 2017-07-12 Links
Acetylsalicylic Acid Aspirin Analgesia, swelling, prophylaxis of venous embolism and further heart attacks or strokes Yes Yes Yes Yes No Yes Yes Yes PTGS1; PTGS2; AKR1C1; PRKAA1; EDNRA; TP53; HSPA5; RPS6KA3; NFKBIA; TNFAIP6; CASP1; CASP3; IKBKB; MAPK1; CCND1; MYC; PCNA; NEU1; 2017-08-23 Links
Adapalene Acne No Yes Yes Yes No No No No RARB; RARG; RXRB; RXRG; RXRA; JUN; TLR2; RARA; GOT1; 2020-02-05 Links
Ademetionine AdoMet, S-Adenosylmethionine Liver disease No Yes Yes Yes No No Yes Yes COMT; CMTR1; AS3MT; GNMT; AMD1; MAT2A; CBS; MAT1A; 2018-09-19 Links
Agomelatine Insomnia No No Yes No No No No No HTR2C; MTNR1A; MTNR1B; 2017-07-13 Links
Albendazole Parasitic infection Yes Yes Yes Yes Yes No Yes Yes TUBA1A; TUBB4B; 2021-07-23 Links
Alendronic Acid Alendronate Osteoporosis No Yes Yes Yes Yes No Yes Yes FDPS; PTPN4; PTPRS; PTPRE; ATP6V1A; 2018-03-12 Links
Aliskiren Essential hypertension No Yes Yes No No No No No REN; 2021-08-02 Links
Allopurinol Gout Yes Yes Yes Yes No No Yes Yes XDH; 2017-07-14 Links
Alpha-Lipoic Acid Thioctic Acid, Lipoic Acid Diabetic neuropathy (Germany) No Yes Yes Yes Yes No Yes Yes LIPT1; SLC5A6; LIAS; 2017-07-14 Links
Amantadine Parkinson's Disease, Influenza A No Yes Yes No No No No No M; GRIN3A; DRD2; CHRNA7; CHRNA4; CHRNA3; 2017-07-18 Links
Ambroxol Excessive mucus No Yes Yes Yes No No No No 2021-01-19 Links
Amiloride In congestive heart failure or hypertension treated with thiazides, to conserve potassium Yes Yes Yes Yes No No No No SCNN1A; SCNN1B; SCNN1G; SCNN1D; AOC1; ASIC2; ASIC1; SLC9A1; PLAU; 2017-07-18 Links
Aminophylline Asthma, chronic bronchitis No Yes Yes Yes No No Yes Yes PDE3A; ADORA1; ADORA3; HDAC2; 2020-02-17 Links
Amiodarone Ventricular tachycardia/fibrillation Yes Yes Yes Yes No No Yes Yes KCNH2; ADRB1; CACNA1I; CACNA1C; THRA; PPARG; PPARA; PPARGC1B; 2017-07-19 Links
Amitriptyline Depression Yes Yes Yes Yes No No No No SLC6A2; SLC6A4; HTR2A; HTR1A; OPRD1; OPRK1; NTRK1; NTRK2; ADRA1A; ADRA1D; ADRA2A; HRH1; KCNQ2; KCNA1; HRH2; HRH4; SIGMAR1; HTR2C; ADRA1B; HTR7; HTR1D; OPRM1; HTR1B; HTR6; KCNQ3; Htr2c; CHRM1; KCNH2; 2017-08-07 Links
Amlodipine Hypertension Yes Yes Yes Yes No No No No CACNA1C; CACNA1I; CACNA1B; CACNB1; CACNA2D3; CA1; SMPD1; CACNA1B; 2017-08-07 Links
Amodiaquine Malaria Yes Yes Yes No No No No No HNMT; 2017-08-07 Links
Anagrelide Essential thrombocythemia No Yes Yes Yes No No No No PDE3A; 2021-08-02 Links
Anakinra RA, NOMID, CAPS No Yes Yes Yes Yes No Yes Yes IL1R1; 2021-08-02 Links
Aprepitant Nausea, vomiting Yes Yes Yes Yes No No Yes Yes TACR1; 2021-08-02 Links
Aprotinin Perioperative blood loss No No Yes Yes No No Yes Yes PRSS1; CTRB1; PLG; KLK1; 2017-08-21 Links
Argatroban Heparin-induced thrombocytopenia No Yes Yes Yes No No No No F2; 2019-03-20 Links
Aripiprazole Bipolar disorder, major depressive disorder, autistic disorder Yes Yes Yes Yes No No No No DRD2; HTR2A; HTR1A; ADRA1A; ADRA1B; DRD3; HTR1D; HTR7; ADRA2A; ADRA2C; HRH1; HTR1B; HTR2C; HTR3A; HTR6; DRD1; DRD4; ADRA2B; HTR1E; DRD5; HTR2B; HTR5A; ADRB1; ADRB2; HRH2; HRH3; HRH4; CHRM1; CHRM2; CHRM3; CHRM4; CHRM5; OPRK1; OPRM1; OPRD1; GRIN1; SLC6A3; SLC6A4; 2021-02-01 Links
Artesunate Malaria Yes Yes Yes Yes Yes No Yes Yes EXP-1; 2017-08-21 Links
Ascorbic acid Ascorbate, Vitamin C Scurvy Yes Yes Yes Yes Yes No Yes Yes xylA; PLOD2; PHYH; PLOD3; BBOX1; DBH; PAM; P3H1; P3H2; P3H3; P4HA1; OGFOD1; OGFOD2; ALKBH2; ALKBH3; KDM5D; PLOD1; TMLHE; P4HTM; EGLN1; EGLN2; EGLN3; 2017-08-09 Links
Atenolol Hypertension, angina pectoris Yes Yes Yes No No No No No ADRB1; ADRB2; 2017-08-21 Links
Atorvastatin Coronary heart disease, acute coronary syndrome Yes Yes Yes Yes No Yes Yes Yes HMGCR; DPP4; AHR; HDAC2; NR1I3; 2017-08-21 Links
Atovaquone Pneumocystis carinii pneumonia, toxoplasmose No Yes Yes Yes No Yes Yes Yes MT-CYB; DHODH; 2017-08-21 Links
Atrial Natriuretic Peptide Carperitide Heart failure No No Yes Yes No Yes Yes Yes 2021-08-03 Links
Auranofin RA No Yes Yes Yes No No Yes Yes PRDX5; IKBKB; 2017-08-23 Links
Azelastine Allergies No Yes Yes Yes No No No No HRH1; HRH2; PLA2G1B; LTC4S; 2019-08-28 Links
Azithromycin Bacterial infection, CAP, PID Yes Yes Yes Yes No No Yes Yes PADI4; 2017-08-23 Links
Bazedoxifene Osteoporosis No No Yes Yes No No Yes Yes ESR1; ESR2; 2017-08-24 Links
Bedaquiline Tuberculosis Yes No Yes No No No No No atpE; 2017-08-24 Links
Bemiparin Venous thromboembolism, myocardial infarction No No Yes Yes No No Yes Yes F10; SERPINC1; SERPIND1; 2017-08-24 Links
Benserazide Parkinson's Disease Yes Yes Yes Yes No No No No DDC; 2017-08-24 Links
Benzatropine Benztropine Parkinson's Disease No Yes Yes Yes No No No No CHRM1; SLC6A3; HRH1; SLC6A4; SLC6A2; 2018-03-12 Links
Bepridil Hypertension and chronic stable angina No Yes Yes Yes No No No No CACNA1A; CACNA1H; CACNA2D2; ATP1A1; KCNQ1; TNNC1; CALM1; PDE1B; PDE1A; KCNH2; 2017-08-24 Links
Bezafibrate Hyperlipidemia No Yes Yes Yes No No Yes Yes PPARD; PPARG; PPARA; NR1I2; RXRA; RXRB; RXRG; 2017-08-24 Links
Biperiden Parkinson's Disease Yes Yes Yes Yes No No No No CHRM1; 2017-08-24 Links
Bosentan PAH No Yes Yes Yes No No Yes Yes EDNRB; EDNRA; 2017-08-24 Links
Brexpiprazole Schizophrenia, major depressive disorder No Yes Yes Yes No No No No HTR1A; DRD2; DRD3; HTR2A; HTR2B; HTR7; ADRA1A; ADRA1B; ADRA1D; ADRA2C; HRH1; CHRM1; 2023-08-03 Links
Bromhexine Excessive mucus No Yes Yes Yes No No No No TMPRSS2; ACE2; 2021-01-19 Links
Bromocriptine Parkinson's Disease, prevention of lactation Yes Yes Yes Yes No No Yes Yes DRD2; DRD3; HTR1D; ADRA2A; HTR1A; ADRA2C; ADRA2B; HTR2B; DRD4; HTR2A; HTR1B; HTR2C; DRD5; DRD1; ADRA1A; ADRA1B; ADRA1D; HTR7; 2017-08-24 Links
Bumetanide Edema Yes Yes Yes Yes No No Yes Yes SLC12A1; SLC12A2; SLC12A4; SLC12A5; CFTR; 2021-10-25 Links
Bupivacaine Anesthetic Yes Yes Yes Yes No No Yes Yes SCN10A; PTGER1; 2022-10-18 Links
Cabergoline Hyperprolactinemia Yes Yes Yes Yes No No Yes Yes DRD2; HTR2B; DRD3; HTR2A; ADRA2B; HTR1D; DRD4; ADRA2A; HTR1A; ADRA2C; DRD5; DRD1; HTR1B; HTR2C; HTR7; ADRA1A; ADRA1B; ADRA1D; ADRB1; ADRB2; DRD1; 2017-08-23 Links
Caffeine Newborn apnea No Yes Yes Yes Yes Yes Yes Yes ADORA1; ADORA2A; ADORA2B; ADORA3; PDE1B; PDE4B; RYR1; PDE1A; PRKDC; PIK3CD; PIK3CA; PIK3CB; ITPR1; ATM; 2021-08-03 Links
Calcipotriol Vitamin D3 Psoriasis Yes Yes Yes Yes Yes No Yes Yes VDR; 2019-03-21 Links
Calcitriol Vitamin D3 Vitamin D deficiency Yes Yes Yes Yes Yes No Yes Yes VDR; HOXA10; 2017-08-23 Links
Canagliflozin Diabetes Yes No Yes Yes No No Yes Yes SLC5A2; 2021-08-09 Links
Candesartan Hypertension No Yes Yes Yes No No Yes Yes AGTR1; 2017-08-23 Links
Cannabidiol Seizures associated with Lennox-Gastaut & Dravet syndromes No Yes Yes Yes Yes No Yes Yes CNR1; CNR2; GPR12; GLRA1; GLRA1; GLRA3; GPR18; GPR55; HTR1A; HTR2A; CHRNA7; OPRD1; OPRM1; PPARG; TRPV1; CACNA1G; CACNA1H; CACNA1I; TRPA1; TRPM8; TRPV2; TRPV3; TRPV4; VDAC1; HTR3A; ADORA1; PTGS1; PTGS2; ACAT1; CYP17A1; HMGCR; GSR; GPX1; IDO1; CYP1B1; NQO1; CAT; CYP3A5; CYP2D6; SOD1; CYP1A2; CYP3A7; AANAT; NAAA; 2021-11-24 Links
Captopril Hypertension No Yes Yes Yes No No Yes Yes ACE; MMP2; MMP9; LTA4H; BDKRB1; 2017-08-25 Links
Carbimazole Hyperthyroidism Yes Yes Yes No No No No No TPO; 2017-08-25 Links
Carglumic Acid Hyperammonaemia in N-acetylglutamate synthase deficiency No Yes Yes Yes No No No No CPS1; 2021-08-03 Links
Carvedilol Hypertension Yes Yes Yes Yes No Yes Yes Yes ADRB1; ADRA1A; ADRA1A; NDUFC2; ADRB2; VEGFA; NPPB; GJA1; KCNH2; VCAM1; ADRA1D; ADRA1B; ADRA2C; ADRA2B; ADRA2A; SELE; HIF1A; KCNJ4; KCNJ2; 2021-02-27 Links
Celecoxib OA, RA, JRA, AS, acute pain, primary dysmenorrhea No Yes Yes Yes Yes Yes Yes Yes PTGS2; CA2; CA3; CDH11; PDPK1; NEU1; 2021-08-03 Links
Cephalexin Bacterial infections No Yes Yes Yes No No Yes Yes pbp3; pbp2a; pbp1b; penA; pbpA; 2017-08-25 Links
Chloramphenicol Superficial eye infections, typhoid fever Yes Yes Yes No Yes No No Yes rplP; draA; CD55; 2018-02-28 Links
Chloroquine Malaria, Extraintestinal Amebiasis Yes Yes Yes Yes Yes No Yes Yes GSTA2; TNF; TLR9; GST; HMGB1; GSTM1; ACE2; 2021-08-06 Links
Chlorpromazine Psychotic disorders, nausea and vomiting, anxiety, hiccups Yes Yes Yes Yes No No Yes Yes DRD2; DRD1; HTR1A; HTR2A; ADRA1A; ADRA1B; HRH1; KCNH2; DRD1; DRD3; DRD4; DRD5; HTR2C; HTR2A; ADRA1A; ADRA2A; CHRM1; CHRM3; SMPD1; CALM1; ORM1; HTR6; HTR7; HRH4; 2017-08-25 Links
Cholecalciferol Colecalciferol, Vitamin D3 Vitamin D deficiency Yes Yes Yes Yes Yes No Yes Yes VDR; 2017-08-25 Links
Cholera Vaccine Vibrio cholerae vaccine Active immunization against cholera infection Yes N/A No Yes No Yes No Yes 2021-06-24 Links
Cidofovir CMV-retinitis in AIDS No Yes Yes Yes Yes No Yes Yes UL54; 2021-08-06 Links
Cilnidipine Hypertension No Yes Yes Yes No No No No CACNA1B; CACNA1C; 2017-08-30 Links
Cilostazol Intermittent claudication No Yes Yes Yes No No No No PDE3A; 2020-09-24 Links
Cimetidine Duodenal/gastric ulcers, GERD, pathological hypersecretory conditions No Yes Yes Yes Yes No Yes Yes HRH2; 2017-08-31 Links
Ciprofloxacin Antibiotic Yes Yes Yes Yes No No Yes Yes parC; gyrA; TOP2A; KCNH2; gyrA; parC; parE; gyrA; mdtK; gyrA; 2017-09-21 Links
Citalopram Depression Yes Yes Yes Yes No No Yes Yes SLC6A4; HRH1; 2017-08-31 Links
Clarithromycin Bacterial infections Yes Yes Yes Yes Yes No Yes Yes rplJ; KCNH2; SLCO1B1; SLCO1B3; 2017-08-31 Links
Clemastine Allergies No Yes Yes No No No No No HRH1; 2019-08-21 Links
Clioquinol Anti-fungal, anti-infective No Yes Yes Yes No No Yes Yes 2020-03-10 Links
Clodronic Acid Clodronate Osteolytic lesions, hypercalcaemia and bone pain associated with skeletal metastases in patients with breast cancer or multiple myeloma No Yes Yes Yes Yes No Yes Yes SLC25A4; SLC25A5; SLC25A6; 2018-07-02 Links
Clofazimine Leprosy Yes Yes Yes Yes No No Yes Yes PPARG; KCNA3; 2019-03-19 Links
Clofoctol Bacterial infections No Yes Yes Yes No No No No 2017-08-31 Links
Clomifene Ovulatory dysfunction Yes Yes Yes Yes No No Yes Yes ESR1; SHBG; 2017-08-31 Links
Clomipramine Obsessive Compulsive Disorder Yes Yes Yes Yes No No No No SLC6A4; HTR2A; HTR2B; HTR2C; SLC6A2; GSTP1; 2017-08-31 Links
Clopidogrel Stroke, post-myocardial infarction Yes Yes Yes Yes No No Yes Yes P2RY12; 2018-03-01 Links
Clotrimazole Fungal infections Yes Yes Yes Yes No No No No ERG11; KCNN4; NR1I2; HCAR2; 2017-08-31 Links
Colchicine Gout No Yes Yes Yes No No Yes Yes TUBB; 2017-08-31 Links
Cromoglicic Acid Cromolyn, Cromoglycate, Cromoglicate Asthma prophylaxis No Yes Yes Yes No No No No S100P; 2020-08-19 Links
Cyclosporine Cyclosporin Graft versus host disease No Yes Yes Yes Yes No Yes Yes CAMLG; PPP3R2; PPIA; PPIF; 2021-02-01 Links
Cyproheptadine Allergies No Yes Yes Yes Yes Yes Yes Yes HRH1; HTR2A; HTR2C; HRH2; HTR2B; CHRM1; CHRM2; CHRM3; HTR7; 2020-02-17 Links
Dalteparin DVT (prophylaxis), unstable angina/non-Q-wave myocardial infarction Yes Yes Yes Yes Yes No Yes Yes SERPINC1; VEGFA; SELP; 2017-08-31 Links
Danazol Endometriosis, fibrocystic breast disease, hereditary angioedema No Yes Yes Yes No No Yes Yes ESR1; AR; PGR; GNRHR; GNRHR2; CCL2; 2017-09-01 Links
Dapagliflozin Diabetes Yes No Yes Yes Yes No Yes Yes SLC5A2; 2022-02-09 Links
Dapsone Dermatitis herpetiformis, leprosy Yes Yes Yes Yes No No Yes Yes folP2; folP1; 2017-09-01 Links
Deferasirox Acute iron intoxication, chronic iron overload Yes Yes Yes Yes No No Yes Yes 2021-08-10 Links
Deferiprone Iron overload in thalassemia major Yes Yes Yes Yes No No No No 2018-08-14 Links
Deferoxamine Desferrioxamine Acute iron intoxication, chronic iron overload Yes Yes Yes Yes No No Yes Yes APP; 2017-09-01 Links
Defibrotide Severe hepatic veno-occlusive disease No No Yes Yes No No Yes Yes ADORA1; ADORA2A; ADORA2B; 2021-03-18 Links
Desloratadine Allergies No Yes Yes No No Yes No Yes HRH1; 2020-10-21 Links
Desmopressin Diabetes Insipidus, bedwetting, hemophilia A, von Willebrand's disease Yes Yes Yes Yes No No Yes Yes AVPR2; AVPR1A; AVPR1B; 2017-09-01 Links
Diazoxide Chronic intractable hypoglycaemia, acute hypertension Yes Yes Yes Yes Yes No Yes Yes KCNJ11; ATP5A1; 2019-08-21 Links
Diclofenac OA, RA, AS No Yes Yes Yes Yes No Yes Yes PTGS2; PTGS1; 2017-09-01 Links
Diflunisal OA, RA, mild to moderate pain No Yes Yes Yes No No No No PTGS2; PTGS1; 2017-09-01 Links
Digitoxin Congestive HF, atrial fibrillation, atrial flutter, PAT, cardiogenic shock No Yes Yes Yes No No Yes Yes ATP1A1; 2017-09-01 Links
Digoxin Heart failure, atrial fibrillation Yes Yes Yes Yes No No Yes Yes ATP1A1; 2017-09-01 Links
Dimethyl Fumarate Psoriasis, Multiple Sclerosis No Yes Yes Yes No No Yes Yes KEAP1; RELA; 2017-09-01 Links
Diphtheria vaccine Diphtheria Toxoid, DTP vaccine, DT vaccine, Td vaccine Active immunization against diphtheria infection Yes N/A Yes Yes Yes No Yes Yes 2021-06-24 Links
Dipyridamole Thromboembolism Prophylaxis Post-Cardiac Valve Replacement No Yes Yes Yes No No Yes Yes PDE10A; PDE5A; PDE4A; ADA; RCAN1; ORM1; 2017-09-01 Links
Disulfiram Antabuse Chronic alcoholism No Yes Yes Yes Yes No Yes Yes DBH; ALDH2; 2021-08-06 Links
Donepezil Alzheimer's Disease No Yes Yes Yes No No Yes Yes ACHE; HTR2A; BCHE; NOS1; TNFAIP6; IL1B; NFKB2; GRIN1; 2017-10-17 Links
Doxazosin Hypertension, benign prostatic hyperplasia No Yes Yes Yes No No No No ADRA1A; ADRA1D; KCNH2; ADRA1B; 2017-10-17 Links
Doxycycline Respiratory/urinary tract/ophtalmic infection Yes Yes Yes Yes Yes No Yes Yes 2017-10-17 Links
Dronedarone Paroxysmal or persistent atrial fibrillation No Yes Yes Yes No No No No ADRA1A; ADRA1B; ADRA1D; ADRA2A; ADRA2B; ADRA2C; KCNH2; CACNA1C; CACNA1D; CACNA1F; CACNA1S; CACNB1; CACNB2; CACNB3; CACNB4; KCNK2; SCN5A; KCNJ3; KCNQ1; KCNJ12; SLC8A1; KCND3; ADRB1; THRA; 2018-12-19 Links
Dutasteride Benign prostatic hyperplasia No Yes Yes Yes Yes No Yes Yes SRD5A1; SRD5A2; 2018-08-14 Links
Ebastine Allergies No Yes Yes Yes No Yes No Yes 2022-02-09 Links
Efavirenz Anti-retroviral Yes Yes Yes Yes No No Yes Yes pol; 2017-10-17 Links
Eltrombopag Chronic immune (idiopathic) thrombocytopenia No No Yes Yes No No Yes Yes MPL; 2021-02-17 Links
Emetine Amoebiasis No Yes Yes Yes No No No No 2020-02-17 Links
Enalapril Hypertension Yes Yes Yes Yes No No Yes Yes ACE; 2017-10-26 Links
Enoxacin Urinary tract infections No Unclear Yes Yes No No No No gyrA; parC; TOP2A; 2020-08-19 Links
Enoxaparin Prophylaxis of venous thromboembolism Yes Yes Yes Yes No No Yes Yes SERPINC1; F10; F2; 2017-10-26 Links
Epalrestat Diabetes No Yes Yes Yes No No Yes Yes 2017-10-26 Links
Esomeprazole Antacid No Yes Yes Yes Yes Yes Yes Yes ATP4A; DDAH1; 2017-10-26 Links
Ethacrynic Acid Etacrynic acid Diuretic No Yes Yes Yes Yes No No Yes SLC12A1; ATP1A1; LEF1; GSTP1; 2017-10-26 Links
Etodolac Analgesia No Yes Yes Yes Yes No Yes Yes PTGS2; PTGS1; RXRA; 2017-10-26 Links
Etoricoxib OA, RA, AS No Yes Yes Yes No No Yes Yes PTGS2; 2019-03-19 Links
Famotidine Antacid No Yes Yes Yes No No Yes Yes HRH2; 2017-10-26 Links
Fasudil Vasodilator No Unclear Yes Yes No No No No PKIA; PRKACA; ROCK1; ROCK2; 2017-10-26 Links
Felodipine Hypertension No Yes Yes Yes No No No No CACNA1C; CACNA2D1; CACNB2; CACNA1D; CACNA1S; CACNA1H; CACNA2D2; CALM1; PDE1B; PDE1A; NR3C2; TNNC2; TNNC1; 2017-10-26 Links
Fenofibrate Hyperlipidemia No Yes Yes Yes Yes No Yes Yes PPARA; NR1I2; MMP25; 2017-10-26 Links
Fenoldopam Acute hypertension No Yes Yes Yes No No No No DRD5; DRD1; ADRA1B; ADRA1D; ADRA1A; ADRA2B; ADRA2C; ADRA2A; 2019-08-21 Links
Fexofenadine Allergies Yes Yes Yes Yes No No No No HRH1; 2022-02-09 Links
Finasteride Benign prostatic hyperplasia No Yes Yes Yes Yes Yes Yes Yes SRD5A2; SRD5A1; AKR1D1; 2018-08-14 Links
Fingolimod Multiple Sclerosis No Yes Yes Yes No No Yes Yes S1PR5; S1PR1; S1PR3; HDAC1; S1PR4; 2021-08-06 Links
Flubendazole Parasitic infection No Yes Yes Yes No No No No 2017-10-30 Links
Flucytosine 5-Fluorocytosine Candida and/or Cryptococcus Yes Yes Yes Yes No No Yes Yes DNMT1; TMP1; 2018-06-27 Links
Flunarizine Migraine No Yes Yes Yes No No No No CACNA1G; CACNA1H; CACNA1I; CALM1; HRH1; 2018-12-19 Links
Fluoxetine Prozac Depression Yes Yes Yes Yes No No No No SLC6A4; HTR2C; CHRNA2; CHRNA3; CHRNB4; CKS1B; KCNH2; 2017-10-30 Links
Fluphenazine Psychotic disorders Yes Yes Yes Yes No No Yes Yes DRD2; DRD1; CALM1; AR; HTR2A; HTR2C; 2019-05-01 Links
Flurbiprofen Analgesia No Yes Yes Yes No Yes Yes Yes PTGS2; PTGS1; 2018-08-09 Links
Fluspirilene Psychotic disorders No Yes Yes Yes No No No No DRD2; HTR2A; CACNG1; 2017-10-30 Links
Fluvastatin Hyperlipidemia Yes Yes Yes Yes Yes Yes Yes Yes HMGCR; HDAC2; 2017-10-31 Links
Fluvoxamine Depression Yes Yes Yes Yes Yes No No Yes SLC6A4; KCNH2; 2017-10-31 Links
Fostamatinib Chronic immune thrombocytopenia No No Yes Yes No No Yes Yes SYK; ADORA3; SLC18A2; FAAH; SLC29A1; UGT1A1; PDE5A; ALOX5; CTSS; CTSL; ABL1; CPK1; pknB; RPS6KA6; TYK2; COQ8A; JAK1; MET; NIM1K; STK26; PRKACA; STK24; STK3; TEC; STK33; STK35; STK36; STK38; STK38L; STK39; TAOK1; TAOK2; TAOK3; TBK1; TEK; TESK1; TGFBR1; TGFBR2; TIE1; TLK1; TLK2; TNIK; TNK1; TNK2; TNNI3K; TSSK1B; TTK; TXK; TYRO3; ULK1; ULK2; ULK3; WEE1; YES1; MAP3K19; ZAK; ZAP70; AAK1; ABL2; ACVR1; ACVR1B; COQ8B; ALK; ANKK1; AURKA; AURKB; AURKC; AXL; BLK; BMP2K; BMPR1B; BMPR2; BMX; BRAF; BTK; CAMK1; CAMK1D; CAMK1G; CAMK2A; CAMK2B; CAMK2D; CAMK2G; CAMKK1; CAMKK2; CASK; CSN3; CDK1; CDC42BPG; CDK4; CDKL1; CDKL2; CHEK1; CHEK2; CIT; CLK1; CLK2; CLK3; CLK4; CSF1R; CSK; CSNK1A1; CSNK2A1; CSNK2A2; DAPK1; DAPK2; DAPK3; DCLK1; DCLK2; DCLK3; DDR1; DDR2; DYRK1A; DYRK1B; EGFR; EIF2AK1; EIF2AK2; EIF2AK4; EPHA1; EPHA2; EPHA3; EPHA4; EPHA5; EPHA6; EPHA7; EPHA8; EPHB1; EPHB2; EPHB4; EPHB6; ERBB2; ERBB4; ERN1; FER; FES; FGFR1; FGFR2; FGFR3; FGR; FLT1; FLT3; FLT4; MTOR; FRK; FYN; GAK; GSK3A; GSK3B; HCK; HIPK2; HIPK3; ICK; IKBKB; IKBKE; INSR; INSRR; IRAK1; IRAK3; IRAK4; ITK; JAK2; JAK3; KDR; SIK3; KIT; LATS1; LCK; LIMK1; LIMK2; LRRK2; LTK; LYN; MAP2K2; MAP2K3; MAP2K5; MAP2K6; MAP3K1; MAP3K10; MAP3K11; MAP3K12; MAP3K13; MAP3K15; MAP3K2; MAP3K3; MAP3K4; MAP3K6; MAP3K9; MAP4K1; MAP4K2; MAP4K3; MAP4K4; MAP4K5; MAPK10; MAPK13; MAPK14; MAPK15; MAPK4; MAPK7; MAPK9; MAPKAPK5; MARK1; MARK2; MARK3; MARK4; CLASP1; MAST1; MATK; MELK; MERTK; MINK1; MKNK1; MKNK2; MST1R; MUSK; MYLK; MYLK2; MYLK3; MYLK4; MYO3A; NEK1; NEK11; NEK2; NEK3; NEK4; NEK5; NEK9; NTRK1; NTRK2; NTRK3; NUAK1; NUAK2; OXSR1; PAK1; PAK2; PAK3; PAK4; PAK6; PAK5; CDK16; CDK17; PDGFRA; PDGFRB; PDPK1; CDK15; PHKG1; PI4KB; PIK3C2B; PIK3C2G; PIK3CD; PIK3CG; PIM1; PIM3; PIP4K2B; PIP4K2C; PKMYT1; PKN1; PKN2; PLK1; PLK2; PLK3; PLK4; PRKAA1; PRKAA1; PRKACB; PRKCD; PRKCE; PRKCG; PRKCI; PRKCQ; PRKD1; PRKG2; PRPF4B; PTK2; PTK2B; PTK6; RAF1; RET; RIOK1; RIOK2; RIOK3; RIPK1; RIPK2; RIPK4; ROCK2; ROS1; RPS6KA1; RPS6KA3; SBK1; SBK3; SGK3; SIK1; SIK2; SLK; SNRK; SRC; SRMS; STK10; STK16; STK17A; STK17B; STK32A; 2021-03-04 Links
Ganciclovir Anti-viral No Yes Yes Yes Yes No Yes Yes TK; 2018-06-28 Links
Glibenclamide Glyburide Diabetes No Yes Yes Yes No No No No ABCC8; ABCC9; ABCB11; ABCA1; KCNJ11; CPT1A; CFTR; TRPM4; 2018-04-03 Links
Glipizide Diabetes No Yes Yes Yes No No No No ABCC8; PPARG; 2017-11-01 Links
Griseofulvin Fungal infections Yes Yes Yes Yes Yes No No Yes KRT12; 2017-11-02 Links
Haloperidol Psychotic disorders Yes Yes Yes Yes No No No No HTR2C; DRD2; HTR2A; DRD3; MCHR1; SLC18A2; SIGMAR1; HRH1; CHRM3; ADRA1A; ADRA2A; ADRA2B; ADRA2C; HTR1A; HTR6; HTR7; GRIN2B; DRD1; 2017-11-06 Links
HPV vaccine Human Papillomavirus vaccine, Papillomavirus vaccine Prevention of HPV-induced premalignant genital lesions No N/A No No Yes Yes Yes Yes 2021-06-24 Links
Hydralazine Hypertension Yes Yes Yes Yes No No Yes Yes AOC3; HIF1A; P4HA1; 2017-11-07 Links
Hydroxychloroquine Malaria Yes Yes Yes Yes Yes No Yes Yes TLR7; TLR9; ACE2; 2018-01-04 Links
Hymecromone Antispasmodic No Yes Yes Yes No No Yes Yes assT; 2017-11-07 Links
Ibandronic Acid Ibandronate Osteoporosis No Yes Yes Yes Yes No Yes Yes GGPS1; FDPS; 2021-08-09 Links
Ibudilast Multiple sclerosis, asthma, cerebrovascular disease No Yes Yes Yes No No Yes Yes PDE4A; PDE4B; PDE4C; PDE4D; PDE3A; 2020-02-18 Links
Ibuprofen Analgesia Yes Yes Yes Yes No No Yes Yes PTGS2; PTGS1; BCL2; THBD; FABP2; PPARG; CFTR; PPARA; GP1BA; S100A7; 2017-11-07 Links
Idebenone Leber's Hereditary Optic Neuropathy No No Yes No No No No No 2019-03-19 Links
Imipramine Depression No Yes Yes Yes No No Yes Yes SLC6A2; SLC6A4; HTR2A; HRH1; ADRA1A; ADRA1D; CHRM1; CHRM2; CHRM3; CHRM4; CHRM5; KCND2; KCND3; HTR2C; ADRA1B; HTR7; DRD1; DRD2; KCNH2; SLC6A3; HTR1A; HTR6; KCNH1; ORM2; 2017-11-07 Links
Indinavir Anti-retroviral No Yes Yes Yes No No Yes Yes pol; 2020-06-29 Links
Indomethacin Indometacin Analgesia No Yes Yes Yes Yes No Yes Yes PTGS2; PLA2G2A; PTGS1; PTGR2; PPARG; GLO1; PTGDR2; PPARA; AKR1C3; EIF2AK2; PTGS1; 2017-11-20 Links
Influenza vaccine Flu vaccine, influenzavirus vaccine Active immunization against flu infection Yes N/A Yes Yes No Yes Yes Yes 2021-06-24 Links
Irbesartan Hypertension No Yes Yes Yes Yes Yes No Yes AGTR1; JUN; 2017-11-20 Links
Itraconazole Fungal infections Yes Yes Yes Yes Yes Yes Yes Yes ERG11; 2017-11-20 Links
Ivermectin Parasitic infection Yes Yes Yes Yes No No Yes Yes 2017-06-09 Links
Ketamine Anesthetic Yes Yes Yes Yes No No Yes Yes GRIN3A; HTR3A; CHRNA7; BCHE; NOS1; TACR1; DRD2; OPRD1; SLC6A2; OPRK1; OPRM1; CHRM1; HTR2A; HTR1A; 2018-08-09 Links
Ketoconazole Fungal infections No Yes Yes Yes Yes Yes Yes Yes ERG11; CYP17A1; AR; CYP21A2; KCNH2; NR1I2; NR1I3; 2017-11-27 Links
Ketoprofen Analgesia No Yes Yes Yes No No No No PTGS2; PTGS1; CXCR1; 2019-03-19 Links
Ketorolac Post-operative analgesia No Yes Yes Yes Yes Yes Yes Yes PTGS2; PTGS1; 2017-11-29 Links
Lamotrigine Epilepsy Yes Yes Yes Yes No No No No CACNA1E; SCN1A; ADORA1; ADORA2A; ADRA1A; ADRA2A; ADRB1; DRD1; DRD2; GABRA1; GABRA1; HRH1; OPRK1; CHRNA1; HTR2A; HTR3A; GRIA1; 2018-03-12 Links
Lansoprazole Antacid No Yes Yes Yes No Yes Yes Yes ATP4A; MAPT; 2021-08-09 Links
L-Arginine Nutraceutical No Yes Yes Yes No No Yes Yes 2021-08-03 Links
Leflunomide Arthritis No Yes Yes Yes No No Yes Yes DHODH; AHR; PTK2B; 2020-02-17 Links
Levamisole Parasitic infection Yes Yes Yes Yes Yes No Yes Yes CHRNA3; ALPPL2; unc-38; unc-63; lev-1; unc-29; 2019-01-22 Links
Levetiracetam Epilepsy Yes Yes Yes Yes Yes Yes Yes Yes CACNA1B; SV2A; 2021-08-17 Links
Levofloxacin Antibiotic Yes Yes Yes Yes Yes No No Yes gyrA; parC; 2017-12-05 Links
Levonorgestrel Contraceptive Yes Yes Yes Yes Yes Yes Yes Yes PGR; SRD5A1; ESR1; AR; SHBG; NR3C1; 2018-08-09 Links
L-Glutamine Sickle cell disease No Yes Yes Yes No No Yes Yes CTPS1; PPAT; GLUL; 2022-07-18 Links
Lidocaine Anesthetic Yes Yes Yes Yes No No Yes Yes SCN10A; SCN9A; SCN5A; EGFR; SCN4A; ORM1; ORM2; 2017-12-06 Links
Linagliptin Diabetes No Yes Yes Yes No No Yes Yes DPP4; 2021-11-04 Links
Liothyronine Hypothyroidism No Yes Yes Yes Yes Yes Yes Yes THRA; THRB; PCNA; 2020-11-18 Links
Liraglutide Diabetes No No Yes No No No No No GLP1R; 2019-01-22 Links
Lithium Bipolar disorders No Yes Yes Yes Yes No Yes Yes 2017-12-06 Links
Lomitapide Familial hypercholesterolemia No No Yes Yes No No No No MTTP; 2023-05-04 Links
Loperamide Diarrhea Yes Yes Yes No No No No No OPRM1; OPRD1; OPRK1; CALM1; POMC; CACNA1A; KCNH2; 2017-12-07 Links
Lopinavir Anti-retroviral Yes Yes Yes Yes No No Yes Yes pol; 2018-01-29 Links
Loratadine Allergies Yes Yes Yes No No Yes No Yes HRH1; KCNH2; 2017-12-07 Links
Losartan Hypertension Yes Yes Yes Yes No Yes Yes Yes AGTR1; 2021-08-09 Links
Lovastatin Hyperlipidemia Yes Yes Yes Yes Yes No Yes Yes HMGCR; ITGAL; HDAC2; 2017-12-11 Links
Loxoprofen Analgesia No Yes Yes Yes Yes Yes No Yes PTGS2; PTGS1; 2017-12-11 Links
Macitentan Pulmonary arterial hypertension No No Yes Yes No No Yes Yes EDNRA; EDNRB; 2017-12-11 Links
Manidipine Hypertension No Yes Yes Yes No No No No CACNA1C; CACNA1G; CACNA1G; CACNA1H; CACNA1I; 2017-12-11 Links
Maprotiline Depression No Yes Yes Yes No No Yes Yes SLC6A2; HRH1; CHRM1; CHRM2; CHRM3; CHRM4; CHRM5; ADRA1A; HTR2A; HTR2C; HTR7; DRD2; ADRA2A; 2021-10-25 Links
Maraviroc Anti-retroviral No Yes Yes Yes No No Yes Yes CCR5; 2023-08-03 Links
Measles vaccine MMR vaccine Active immunization against measles infection Yes N/A Yes Yes No Yes Yes Yes 2021-06-24 Links
Mebendazole Parasitic infection Yes Yes Yes Yes Yes No Yes Yes TUBA1A; TUBB4B; 2021-08-09 Links
Meclizine Meclozine Antiemetic No Yes Yes No No No Yes Yes HRH1; NR1I3; 2019-08-21 Links
Meclofenamate Meclofenamic Acid Analgesia No Yes Yes Yes No No Yes Yes PTGS1; PTGS2; ALOX5; KCNQ2; KCNQ3; 2017-12-12 Links
Mefenamic Acid RA, OA, analgesia No Yes Yes Yes No No No No PTGS2; PTGS1; 2020-03-02 Links
Mefloquine Malaria Yes Yes Yes Yes No No Yes Yes ADORA2A; 2021-08-09 Links
Megestrol Acetate Hormone No Yes Yes Yes Yes No Yes Yes PGR; NR3C1; 2017-12-12 Links
Melatonin Insomnia No Yes Yes Yes Yes No Yes Yes MTNR1A; MTNR1B; ESR1; RORB; CALM1; MPO; EPX; CALR; ASMT; NQO2; 2017-12-13 Links
Meloxicam Analgesia No Yes Yes Yes Yes No Yes Yes PTGS2; PTGS1; 2017-12-15 Links
Memantine Alzheimer's Disease No Yes Yes No No No Yes Yes GRIN1; HTR3A; CHRNA7; DRD2; GRIN1; GABRA1; GLRA1; 2018-01-04 Links
Menadione Vitamin K3 Reversal of major bleeding after Warfarin No Yes Yes Yes No No Yes Yes GGCX; VKORC1; VKORC1L1; F2; F9; PROC; PROS1; NQO2; NQO1; BGLAP; 2020-07-27 Links
Menatetrenone Menaquinone-4, MK-4 Osteoporosis No Unclear Yes Yes Yes No Yes Yes 2020-02-25 Links
Mepacrine Quinacrine Parasitic infection No Yes Yes Yes No No Yes Yes PLA2G6; PLA2G4A; PLCL1; 2018-01-04 Links
Mepyramine Allergies No Yes Yes Yes No No No No HRH1; 2019-03-20 Links
Mesalazine Mesalamine, 5-aminosalicylic acid Inflammatory bowel disease Yes Yes Yes Yes No No Yes Yes PTGS2; PTGS1; ALOX5; PPARG; CHUK; IKBKB; NOS2; 2021-08-18 Links
Metformin Diabetes Yes Yes Yes Yes Yes Yes Yes Yes ETFDH; PRKAB1; GPD1; 2017-12-15 Links
Methazolamide Antiglaucoma, diuretic No Yes No No No No Yes Yes CA1; CA4; CA2; CA7; CA3; 2017-12-15 Links
Methimazole Thiamazole Hyperthyroidism Yes Yes No No Yes No Yes Yes TPO; 2017-12-15 Links
Methylene Blue Methylthioninium chloride Methemoglobinemia, cyanide toxicity No Yes Yes Yes No No Yes Yes GUCY1A2; NOS1; 2019-03-26 Links
Methylnaltrexone Opioid-induced constipation No Yes Yes Yes No Yes No Yes OPRM1; OPRK1; 2021-08-09 Links
Metoclopramide Anti-emesis Yes Yes Yes Yes No No Yes Yes HTR4; HTR3A; CHRM1; DRD2; 2017-12-18 Links
Metronidazole Bacterial infection Yes Yes Yes Yes No No Yes Yes rdxA; 2020-09-07 Links
Metyrapone Adrenal insufficiency, Cushing's syndrome No Yes No Yes Yes No No Yes CYP11B1; camC; 2020-03-11 Links
Miconazole Fungal infections Yes Yes Yes Yes No No Yes Yes ERG11; NOS3; NOS2; NR1I2; KCNMA1; KCNA1; KCNJ12; CACNA1C; 2019-08-13 Links
Midazolam Sedation Yes Yes Yes Yes No No No No GABRA1; GABRA1; ADORA2A; 2018-03-12 Links
Mifepristone Abortifacient No Yes Yes Yes Yes No Yes Yes PGR; NR3C1; KLK3; NR1I2; 2017-12-19 Links
Miltefosine Hexadecylphosphocholine Leishmaniasis Yes Yes Yes Yes Yes No Yes Yes ABCB1; 2020-02-17 Links
Minocycline Antibiotic No Yes Yes Yes No No Yes Yes rpsI; rpsD; IL1B; ALOX5; MMP9; VEGFA; CASP1; CASP3; CYCS; MAPK1; NOS2; 2017-12-20 Links
Minoxidil Antihypertensive, alopecia No Yes Yes Yes No No No No KCNJ1; REN; PTGS1; 2020-06-23 Links
Mirtazapine Depression No Yes Yes Yes No No No No HTR2A; ADRA2A; ADRA1A; HTR2C; OPRK1; HRH1; 2017-12-20 Links
Mometasone Mometasone furoate Asthma prophylaxis Yes Yes Yes No No No No No NR3C1; PGR; 2018-02-15 Links
Montelukast Allergies No Yes Yes Yes No No No No CYSLTR1; ALOX5; 2017-12-20 Links
Mumps vaccine MMR vaccine Active immunization against mumps infection Yes N/A Yes Yes No No No No 2021-06-24 Links
Mycophenolate Mycophenolic acid Immunosuppressant No Yes Yes Yes Yes No Yes Yes IMPDH2; IMPDH1; 2021-08-09 Links
Nadroparin Prophylaxis of venous thromboembolism Yes Yes Yes Yes No Yes Yes Yes SERPINC1; SELP; FOS; MYC; 2021-08-09 Links
Naftopidil Benign prostatic hyperplasia No Unclear Yes Yes Yes Yes Yes Yes 2018-02-06 Links
Naltrexone Opioid receptor antagonist Yes Yes Yes Yes Yes No Yes Yes OPRM1; OPRK1; OPRD1; SIGMAR1; 2018-01-03 Links
Naproxen Analgesia No Yes Yes Yes Yes No Yes Yes PTGS1; PTGS2; pab; 2018-01-03 Links
Nelfinavir Anti-retroviral No Yes Yes Yes Yes No Yes Yes HIV-1 protease; 2021-08-09 Links
Nicardipine Hypertension, angina pectoris No Yes Yes Yes Yes No Yes Yes CACNA1C; CACNB2; CACNA2D1; CACNA1D; PDE1A; PDE1B; ADRA1A; ADRA1B; ADRA1D; CHRM1; CHRM2; CHRM3; CHRM4; CHRM5; CALM1; CACNG1; CACNA1G; CACNA1H; CACNA1I; 2021-03-17 Links
Niclosamide Parasitic infection Yes Yes Yes Yes No No Yes Yes 2021-08-09 Links
Nicotinamide Niacinamide Niacin Deficiency, Skin cancer chemoprevention Yes Yes Yes Yes No No Yes Yes BST1; eta; SIRT5; LDHA; PARP1; 2018-03-01 Links
Nifedipine Hypertension Yes Yes Yes Yes Yes No Yes Yes CACNA1C; CACNA1D; CACNB2; NR1I2; CALM1; CACNA1S; KCND3; CACNA1G; 2018-01-03 Links
Nifuroxazide Colitis, acute diarrhea No Yes Yes Yes No No No No 2019-06-26 Links
Nifurtimox Chagas disease, African sleeping sickness Yes Unclear Yes Yes Yes No Yes Yes 2018-01-03 Links
Nimesulide Analgesia No Yes Yes Yes No No Yes Yes PTGS2; PLA2G2E; LTF; 2018-12-19 Links
Nimodipine Hypertension No Yes Yes Yes No No No No CACNA1C; CACNA1D; CACNA1F; CACNA1S; CACNB1; CACNB2; CACNB3; CACNB4; NR3C2; AHR; 2018-01-04 Links
Nisoldipine Hypertension No Yes Yes Yes No No No No CACNA1C; CACNA2D1; CACNB2; CACNA1D; CACNA1S; 2018-01-04 Links
Nitazoxanide Anti-protozoal No Yes Yes Yes No No Yes Yes por; 2021-08-09 Links
Nitisinone Hereditary tyrosinemia type 1 No Yes No No Yes No No Yes HPD; 2021-08-09 Links
Nitroglycerin Glyceryl trinitrate Nitro-vasodilator Yes Yes Yes Yes Yes No Yes Yes NPR1; 2018-01-04 Links
Nitroxoline Antibiotic No Yes Yes Yes No No Yes Yes METAP2; 2018-01-04 Links
Norethandrolone Aplastic anemia No Yes Yes Yes No No Yes Yes 2017-08-23 Links
Noscapine Anti-tussive No Yes Yes Yes No No Yes Yes SIGMAR1; 2018-01-04 Links
Obeticholic Acid Primary biliary cholangitis No No Yes Yes No No No No NR1H4; 2019-03-20 Links
Olanzapine Psychotic disorders Yes Yes Yes Yes No No No No HTR2A; DRD2; DRD1; DRD5; DRD3; DRD4; HTR2C; HTR3A; HTR6; HRH1; ADRA1A; ADRA1B; CHRM1; CHRM2; CHRM3; CHRM4; DRD1; ADRB1; HTR1A; GABRA1; 2017-10-30 Links
Olmesartan Hypertension No Yes Yes Yes No No No No AGTR1; 2018-02-21 Links
Olsalazine Rheumatoid arthritis; ulcerative colitis; active Crohn's Disease. No Yes Yes Yes No No No No PTGS1; TPMT; IFNG; XDH; 2018-01-08 Links
Omega 3 Lovaza, Fish Oil, Omacor, eicosapentaenoic acid, docosahexaenoic acid Hyperlipidemia No Unclear Yes Yes Yes Yes Yes Yes DGAT2; PTGS2; FFAR4; CACNA1C; SCN1A; NFKB2; SREBF1; PPARA; PPARG; PPARD; 2018-01-31 Links
Omeprazole Antacid Yes Yes Yes Yes Yes No Yes Yes ATP4A; AHR; 2018-01-08 Links
Orlistat Obesity No Yes Yes Yes No No No No PNLIP; LIPF; FASN; 2017-10-02 Links
Ormeloxifene Contraceptive No Yes Yes Yes No No No No ESR1; ESR2; 2018-01-09 Links
Oseltamivir Anti-viral Yes Yes Yes Yes No No No No NA; NEU1; NEU2; 2018-01-09 Links
Ospemifene Vulvar and vaginal atrophy No Yes Yes Yes No No No No ESR1; 2023-08-03 Links
Ouabain Cardiac arrhythmia No Yes Yes Yes No No No No ATP1A1; ATP1A2; ATP1A3; 2018-01-10 Links
Oxcarbazepine Epilepsy No Yes Yes No No Yes No Yes SCN1A; 2017-06-12 Links
Pamidronic Acid Pamidronate Osteoporosis No Yes Yes Yes Yes No Yes Yes FDPS; GGPS1; CASP3; CASP9; 2018-02-06 Links
Pantoprazole Antacid No Yes Yes Yes Yes Yes Yes Yes ATP4A; DDAH1; 2018-01-10 Links
Parecoxib Post-operative analgesia No Yes Yes Yes No No Yes Yes PTGS2; LTF; 2018-09-24 Links
Paricalcitol Vitamin D2 Hyperparathyroidism No Yes Yes Yes Yes No Yes Yes VDR; 2018-08-09 Links
Paroxetine Depression Yes Yes Yes Yes No No No No SLC6A4; SLC6A2; HTR2A; ADRA1A; ADRA2A; ADRB1; DRD2; HRH1; HTR1A; CHRM1; HTR2B; DRD1; 2018-12-19 Links
Penfluridol Psychotic disorders No Yes Yes Yes No No No No 2018-01-11 Links
Pentamidine Parasitic infection Yes Yes Yes Yes No No Yes Yes TRDMT1; 2018-01-11 Links
Pentoxifylline Peripheral artery disease No Yes Yes Yes No No Yes Yes ADORA2A; ADORA1; NT5E; 2018-01-15 Links
Perampanel Epilepsy No No Yes No No Yes No Yes GRIA1; 2021-02-03 Links
Perhexiline Anti-angina No Unclear Yes Yes No No No No CPT1A; CPT2; KCNH2; 2022-03-17 Links
Perphenazine Psychotic disorders No Yes Yes Yes No No No No DRD2; DRD1; CALM1; 2018-01-15 Links
Pertussis vaccine DTP vaccine Active immunization against pertussis infection Yes N/A Yes Yes Yes No No Yes 2021-06-24 Links
Phenelzine Depression No Yes Yes Yes No No Yes Yes MAOA; MAOB; AOC3; ABAT; GPT; GPT2; GAD65; 2020-03-04 Links
Phenoxybenzamine Pheochromocytoma No Yes Yes Yes No No No No ADRA1A; ADRA2A; ADRA2C; ADRA2B; CALM1; ADRB2; ADRA1B; ADRA1D; 2018-08-09 Links
Phentolamine Vasodilator No Yes Yes Yes No No No No ADRA1A; ADRA2A; KCNJ11; 2018-01-17 Links
Phenylbutyrate Glycerol Phenylbutyrate Urea cycle disorders No Yes Yes Yes Yes No Yes Yes 2023-08-03 Links
Phenytoin Epilepsy Yes Yes Yes Yes No No Yes Yes SCN5A; SCN1A; KCNH2; CACNA1C; SCN2A; SCN8A; NR1I2; SCN1B; SCN3A; GABRA1; 2021-08-09 Links
Pimozide Psychotic disorders No Yes Yes Yes Yes No No Yes DRD2; DRD3; KCNH2; CALM1; 2018-01-18 Links
Pioglitazone Diabetes No Yes Yes Yes Yes No Yes Yes PPARG; MAOB; 2018-01-18 Links
Pirfenidone Anti-fibrotic No Yes Yes Yes No No Yes Yes 2023-08-03 Links
Piroxicam Analgesia No Yes Yes Yes Yes No Yes Yes PTGS2; PTGS1; 2018-05-22 Links
Pitavastatin Hyperlipidemia No Yes Yes Yes No No Yes Yes HMGCR; ITGAL; 2024-08-14 Links
Plerixafor AMD3100 Autologous HSCT No Yes Yes Yes Yes No Yes Yes CXCR4; 2021-08-09 Links
Pneumococcal vaccine Pneumococcus vaccine, streptococcus pneumoniae vaccine Active immunization against pneumococcal infection Yes N/A No No No No Yes Yes 2021-06-24 Links
Posaconazole Fungal infections No Yes Yes Yes No No Yes Yes ERG11; 2018-12-19 Links
Pravastatin Hyperlipidemia Yes Yes Yes Yes No Yes Yes Yes HMGCR; HDAC2; 2018-01-22 Links
Prazosin Hypertension No Yes Yes Yes No No No No ADRA1A; ADRA1B; ADRA1D; KCNH2; ADRA2A; ADRA2B; ADRA1A; 2018-01-22 Links
Prochlorperazine Prochlorperazine dimaleate Psychotic disorders No Yes Yes Yes No No Yes Yes DRD2; HRH1; ADRA1A; ADRA2A; 2018-02-15 Links
Promethazine Psychotic disorders No Yes Yes Yes No No No No HRH1; DRD2; CHRM1; CHRM2; CHRM3; CHRM4; CHRM5; ADRA1A; CALM1; HRH2; LPAR4; SCN1A; KCNA1; 2018-01-22 Links
Propafenone Anti-arryhtmic No Yes Yes Yes No No No No SCN5A; KCNH2; ADRB1; ADRB2; 2018-01-22 Links
Propofol Anesthetic Yes Yes Yes Yes No Yes Yes Yes GABRB2; GABRB3; GABRA1; SCN4A; SCN2A; 2021-02-10 Links
Propranolol Hypertension Yes Yes Yes Yes Yes Yes Yes Yes ADRB1; ADRB2; ADRB3; HTR1A; HTR1B; 2018-01-22 Links
Pyridoxine Vitamin B6 Vitamin B6 deficiency Yes Yes Yes Yes No No Yes Yes PDXK; 2018-08-14 Links
Pyrimethamine Parasitic infection Yes Yes Yes Yes Yes No Yes Yes DHFR; HEXB; 2021-08-10 Links
Pyronaridine Malaria No Yes Yes Yes No No No No 2020-05-11 Links
Pyrvinium Pamoate Pyrvinium Parasitic infection No Yes Yes Yes No No No No 2018-01-23 Links
Quetiapine Psychotic disorders Yes Yes Yes No No No No No HTR2A; DRD2; HTR1A; HTR1B; HTR1D; HTR1E; HTR2C; HTR3A; HTR6; HTR7; DRD1; DRD5; DRD3; DRD4; HRH1; ADRA1A; ADRA2A; ADRA2B; ADRA2C; CHRM1; CHRM2; CHRM3; CHRM4; CHRM5; 2018-01-23 Links
Rabeprazole Antacid No Yes Yes Yes No No Yes Yes ATP4A; 2018-01-25 Links
Raloxifene Osteoporosis No Yes Yes Yes No Yes Yes Yes ESR1; ESR2; SERPINB9; TFF1; 2020-11-23 Links
Ranitidine Antacid Yes Yes Yes Yes Yes No Yes Yes HRH2; ACHE; 2017-11-02 Links
Ranolazine Anti-angina No Yes Yes Yes No No No No SCN1A; KCNJ12; CACNA1C; ADRA1A; ADRB1; 2021-08-10 Links
Repaglinide Diabetes No Yes Yes Yes No No No No ABCC8; PPARG; HRH1; 2021-08-10 Links
Reserpine Hypertension, anti-psychotic No Yes Yes Yes No No No No SLC18A2; SLC18A1; BIRC5; 2019-01-22 Links
Ribavirin Anti-viral No Yes Yes Yes Yes No Yes Yes IMPDH1; L; IMPDH2; PB1; 2017-06-16 Links
Rifabutin Antibiotic No Yes Yes No No No No No rpoA; rpoB; rpoC; HSP90AA1; HSP90B1; 2018-01-29 Links
Rifampicin Rifampin Tuberculosis No Yes Yes Yes Yes No No Yes rpoB; NR1I2; 2019-04-04 Links
Riluzole ALS No Yes Yes Yes No No Yes Yes SCN5A; SLC7A11; 2018-01-29 Links
Risedronic Acid Risedronate Osteoporosis, prophylaxis of skeletal fractures, Paget's disease No Yes Yes Yes No No Yes Yes FDPS; 2018-09-13 Links
Risperidone Psychotic disorders No Yes Yes Yes No No No No HTR2A; DRD2; ADRA1B; ADRA2B; ADRA1A; ADRA2C; HRH1; HTR2C; HTR1D; HTR1A; HTR7; DRD1; 2018-01-29 Links
Ritonavir Anti-retroviral No Yes Yes Yes Yes No Yes Yes pol; NR1I2; 2021-08-10 Links
Roflumilast COPD No Yes Yes Yes No No Yes Yes PDE4A; 2021-08-10 Links
Rosiglitazone Diabetes No Yes Yes Yes Yes No Yes Yes PPARG; ACSL4; PPARA; PPARD; RXRA; RXRB; RXRG; 2021-03-18 Links
Rosuvastatin Hyperlipidemia No Yes Yes Yes No No Yes Yes HMGCR; ITGAL; 2018-01-30 Links
Rotavirus vaccine Active immunization against rotavirus infection No N/A Yes Yes No No No No 2021-06-24 Links
Roxatidine Antacid No Yes Yes Yes No No No No 2020-02-17 Links
Roxithromycin Bacterial infections No Yes Yes Yes Yes No No Yes rplJ; ABCB1; 2018-05-14 Links
Selumetinib NF1-associated plexiform neurofibromas No No Yes Yes Yes No Yes Yes MAP2K1; MAP2K2; 2021-10-25 Links
Sertraline Depression No Yes Yes Yes No No Yes Yes SLC6A4; SLC6A3; PGRMC1; SLC6A2; SLC29A4; 2018-01-29 Links
Sildenafil Erectile dysfunction No Yes Yes Yes Yes No Yes Yes PDE5A; PDE6G; PDE6H; ODC1; CD274; 2018-01-29 Links
Simvastatin Hyperlipidemia No Yes Yes Yes No Yes Yes Yes HMGCR; ITGAL; HDAC2; 2018-01-30 Links
Sirolimus Rapamycin Inhibit organ transplant rejection No Yes Yes Yes Yes No Yes Yes MTOR; 2018-01-31 Links
Sitagliptin Diabetes No No Yes Yes No Yes Yes Yes DPP4; 2021-01-19 Links
Smallpox vaccine Active immunization against smallpox infection No N/A No No No Yes Yes Yes 2021-06-24 Links
Sodium Aurothiomalate Active progressive rheumatoid arthritis No Yes Yes Yes No No Yes Yes 2018-03-12 Links
Sodium Bicarbonate Relief of wind and griping pains No Yes Yes Yes Yes No Yes Yes 2018-01-30 Links
Spironolactone Congestive cardiac failure, Hepatic cirrhosis with ascites and oedema, Malignant ascites, Nephrotic syndrome, Diagnosis and treatment of primary aldosteronism. No Yes Yes Yes No No Yes Yes NR3C2; NR3C1; AR; PGR; ESR1; NR1I2; CACNA1C; 2017-11-09 Links
Stiripentol Epilepsy (tonic clonic seizure) No No Yes Yes No No No No GABRA1; LDHA; LDHB; 2024-08-14 Links
Sulfasalazine Rheumatoid arthritis; ulcerative colitis; active Crohn's Disease. No Yes Yes Yes Yes No Yes Yes ALOX5; PTGS2; PTGS1; ACAT1; PLA2G1B; SLC7A11; NFKB1; NFKB2; IKBKB; CHUK; PPARG; 2017-11-09 Links
Sulindac Relief of signs and symptoms of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute painful shoulder (acute subacromial bursitis/supraspinatus tendinitis), and acute gouty arthritis. No Yes Yes Yes No Yes Yes Yes PTGS2; PTGS1; AKR1B1; MAPK3; PPARD; PTGDR2; AKR1B10; 2017-11-09 Links
Suramin African sleeping sickness No Unclear Yes Yes Yes No Yes Yes P2RY2; SIRT5; FSHR; RYR1; F2; PLA2G2A; 2019-03-19 Links
Tacalcitol Plaque psoriasis No Unclear Yes Yes No No No No 2020-03-19 Links
Tadalafil Erectile dysfunction No Yes Yes Yes No No Yes Yes PDE5A; PDE11A; PDE6G; 2017-11-09 Links
Tegaserod IBS with constipation No Yes Yes Yes No No No No HTR4; HTR2C; HTR2A; HTR2B; 2020-09-10 Links
Telmisartan Hypertension, cardiovascular prevention No Yes Yes Yes No Yes No Yes PPARG; AGTR1; 2017-11-09 Links
Terbinafine Treatment of tinea pedis (athlete's foot), tinea cruris (dhobie (jock) itch) and tinea corporis (ringworm) No Yes Yes Yes No No Yes Yes ERG1; SQLE; 2017-11-09 Links
Teriflunomide Relapsing multiple sclerosis No Yes Yes Yes No No No No DHODH; 2020-02-17 Links
Tetanus vaccine Tetanus toxoid, DTP vaccine, DT vaccine, Td vaccine Active immunization against tetanus infection No N/A Yes Yes Yes Yes Yes Yes 2021-06-24 Links
Thiabendazole Parasitic infection No Unclear Yes Yes No No No No frdA; 2017-11-09 Links
Thioridazine Psychotic disorders No Yes Yes Yes Yes No Yes Yes DRD2; DRD1; ADRA1A; ADRA1B; HTR2A; KCNH2; 2021-08-09 Links
Ticagrelor Prevention of atherothrombotic events in combo with ASA No Yes Yes Yes No No Yes Yes P2RY12; 2021-08-09 Links
Ticlopidine Prevent strokes, blood loss No Yes Yes Yes Yes No Yes Yes P2RY12; 2017-11-09 Links
Tigecycline Infections No Yes Yes Yes No No Yes Yes rpsI; rpsL; rpsM; rpsN; rpsS; 2021-08-09 Links
Timolol Hypertension, ischemic heart disease, migraine No Yes Yes Yes Yes Yes Yes Yes ADRB1; ADRB2; E; 2021-08-09 Links
Tinzaparin Prophylaxis of venous thromboembolism No Yes Yes Yes No No Yes Yes SERPINC1; ITGA4; CXCL12; 2023-04-05 Links
Tioconazole Parasitic infection No Yes Yes Yes No No No No ERG11; CYP51A1; 2018-01-23 Links
Tocilizumab Rheumatoid arthritis No Yes Yes Yes No No Yes Yes IL6R; 2021-08-10 Links
Tofacitinib Rheumatoid arthritis No No Yes Yes Yes No Yes Yes JAK1; JAK2; JAK3; TYK2; 2021-08-10 Links
Tolfenamic Acid Tolfenamate Migraine No Yes Yes Yes No No No No PTGS1; PTGS2; 2017-11-03 Links
Tolvaptan autosomal dominant polycystic kidney disease, Secondary hyponatremia No Yes Yes Yes No No No No AVPR2; AVPR1A; 2022-06-14 Links
Topiramate Epilepsy (tonic clonic seizure) No Yes Yes Yes No No No No GABRA1; SCN1A; GRIK1; CA2; CA4; CACNA1C; CA1; CA3; CACNA1E; 2017-06-12 Links
Tranexamic Acid Blood loss - fibrinolysis No Yes Yes Yes Yes No Yes Yes PLG; 2017-11-03 Links
Tranilast Bronchial asthma No Yes Yes Yes No No Yes Yes HPGDS; 2020-03-02 Links
Tranylcypromine Depression No Yes Yes Yes No No Yes Yes MAOB; MAOA; 2021-08-13 Links
Trazodone Depression, anxiety No Yes Yes Yes No No No No HTR2A; HTR2C; SLC6A4; HTR1A; HRH1; ADRA1A; ADRA2A; Htr2c; 2023-08-03 Links
Triamterene Diuretic, oedema in cardiac failure, cirrhosis of the liver or the nephrotic syndrome, and in that associated with corticosteroid treatment No Yes Yes Yes No No No No SCNN1G; SCNN1A; SCNN1B; SCNN1D; 2017-11-03 Links
Trientine Triethylenetetramine Wilson's disease No Yes Yes Yes No No Yes Yes 2021-06-23 Links
Trifluoperazine Psychotic disorders No Yes Yes Yes No No Yes Yes DRD2; CALY; ADRA1A; CALM1; TNNC1; S100A4; 2021-08-17 Links
Trimebutine Irritable bowel syndrome No Unclear Yes Yes No No No No OPRM1; CACNA1C; KCNMA1; CHRM1; CHRM2; CHRM3; CHRM4; CACNA1G; 2021-09-01 Links
Trimetazidine Angina pectoris No Yes Yes Yes No No Yes Yes ACAA2; 2018-08-09 Links
Typhoid vaccine Typhoid paratyphoid vaccine, paratyphoid vaccine Active immunization against typhoid infection No N/A Yes Yes No No Yes Yes 2021-06-24 Links
Ulinastatin Severe sepsis & pancreatitis No Unclear Yes Yes No No Yes Yes 2017-11-03 Links
Ursodeoxycholic Acid UCDA, Ursodiol Gallstones, primary biliary cirrhosis No Yes Yes Yes No Yes Yes Yes AKR1C2; NR1H4; 2019-08-28 Links
Valganciclovir Cytomegalovirus in HIV/AIDS No Yes No Yes Yes Yes Yes Yes 2020-07-29 Links
Valproic Acid Valproate Epilepsy No Yes Yes Yes Yes Yes Yes Yes HDAC9; ACADSB; OGDH; ALDH5A1; SCN1A; HDAC2; PPARA; PPARD; PPARG; HDAC1; CDKN1A; HGF; ODC1; CD274; 2017-11-03 Links
Valsartan Hypertension, myocardial infarction, heart failure No Yes Yes Yes No Yes No Yes AGTR1; 2017-11-03 Links
Vardenafil Erectile dysfunction No Yes Yes Yes No No Yes Yes PDE5A; PDE6G; PDE6H; 2021-08-09 Links
Varicella vaccine Chickenpox vaccine, VZV vaccine, shingles vaccine, HHV-3 vaccine, HHV3 vaccine Active immunization against VZV infection No N/A No No No No Yes Yes 2021-06-24 Links
Verapamil Hypertension, angina pectoris No Yes Yes Yes Yes Yes Yes Yes CACNA1C; CACNA1B; CACNA1A; KCNJ11; CACNA1G; CACNA1H; KCNH2; SLC6A4; ADRA1A; ADRA1B; ADRA1D; CACNG1; ABCB1; 2021-08-09 Links
Verteporfin Exudative age-related macular degeneration No No Yes Yes Yes No Yes Yes 2018-08-09 Links
Warfarin Prophylaxis of systemic embolism, of venous thrombosis and pulmonary embolism. No Yes Yes Yes No Yes Yes Yes VKORC1; NR1I2; 2018-01-04 Links
Yellow Fever vaccine Active immunization against yellow fever infection No N/A Yes Yes No Yes No Yes 2021-06-24 Links
Zafirlukast Asthma No Yes Yes Yes No No Yes Yes CYSLTR1; 2023-07-19 Links
Zidovudine Azidothymidine Anti-retroviral No Yes Yes Yes Yes No Yes Yes pol; TERT; 2018-02-22 Links
Zileuton Asthma prophylaxis No Yes Yes Yes No No Yes Yes ALOX5; 2019-01-22 Links
Zoledronic Acid Zoledronate Osteoporosis, prophylaxis of skeletal fractures and treat hypercalcemia of malignancy, treat pain from bone metastases No Yes Yes Yes Yes Yes Yes Yes GGPS1; FDPS; 2017-11-03 Links