Combination of 3 repurposed drugs after chemotherapy failure in lung cancer | Anticancerfund

Combination of 3 repurposed drugs after chemotherapy failure in lung cancer

A prospective phase II, randomised multi-center trial of a biomodulatory treatment with metronomic low-dose treosulfan, pioglitazone and clarithromycin versus nivolumab in patients with squamous cell lung cancer and non-squamous cell lung cancer, respectively, after platin failure (ModuLung).

Cancer types
  • Lung cancer
Trial phase


ACF donation
Estimated trial cost

Why this trial?

Lung cancer is the most common cancer type worldwide and the most common cause of death from cancer. Non-small cell lung cancer (NSCLC) is the main type of lung cancer, accounting for approximately 85% of all lung cancer cases. Approximately 15% of patients survive for at least 5 years after being diagnosed with NSCLC.

In cases where the tumour is small or confined to only one lung, it can be cured by surgery or radiotherapy. Unfortunately, at the time of diagnosis, NSCLCs are often too large, or have spread to other parts of the body. In this case, standard treatment consists of platinum-based chemotherapy. If this first chemotherapy treatment fails, the next option is the recently approved nivolumab.

Scientific data suggest that it is important to act on several aspects of the tumour to achieve a long-term benefit. Preventing the formation of blood vessels that are needed for tumour growth, modulating the inflammatory and immune environment of the tumour, and changing tumour cell behaviour may be more effective, provide a survival benefit, as well as improve the quality of life in patients with advanced cancers.

This study will compare the standard treatment with nivolumab to the experimental treatment, which consists of a combination of 3 oral drugs that are currently on the market for other indications than lung cancer. These drugs could be potentially useful in the treatment of NSCLC because they have shown an effect on both the tumour environment and the tumour cells.

Why this drug?

Clarithromycin is an antibiotic that affects inflammation. In a small trial completed in Japan, NSCLC patients who received clarithromycin showed prolonged survival compared to the group that received standard treatment. In addition, there is evidence that clarithromycin controls tumour-associated inflammation and improves cachexia (a condition in which the patient loses weight and muscle tissue and is weak and tired).

Pioglitazone, currently on the market to treat diabetes, affects the growth of (tumour) cells and cell death.

Treosulfan is a chemotherapeutic drug which will be used at a “metronomic dose”, i.e. at a lower but more frequent dose than the usual schedule.

Trial design

This is a prospective phase II, randomised trial in 10 German centres. Of 86 NSCLC patients, half will receive the experimental treatment with treosulfan, pioglitazone and clarithromycin and the other half will receive nivolumab.

The main objective is to compare the efficacy of the experimental therapy to the efficacy of nivolumab in this specific patient population. Safety and quality of life will also be evaluated.



  • Prof. A. Reichle, University Hospital Regensburg, Regensburg, Germany (Coordinating Investigator)
  • Prof. C. Schulz, University Hospital Regensburg, Regensburg, Germany


  • University Hospital Regensburg, Regensburg, Germany

Our role

financial support + protocol writing
Why we support this trial
Intervention has little or no commercial value
Expected survival benefit
No major hurdle for clinical implementation


Estimated trial cost
ACF donation
ACF internal support (2015-2017)
Questions about participation?
Questions about this trial?
The Anticancer Fund
studies [at]


More info on NCT02852083

Keiichi Mikasa, Jyoshi Sawaki, Eiji Kitab, Kaoru, llamada, Shoji Teramoto, Masahiro Sakamoto, Koichi Maeda, Mitsuru Konishi, Nobuhiro Narita. Significant Survival Benefit to Patients with Advanced Non-Small-Cell Lung Cancer from Treatment with Clarithromycin. Chemotherapy 1997;43:288-296.

Kazandjian D, Suzman LD, Blumenthal G, Mushti S, Kun HE, Libeg M, Keegan P, Pazdur R. FDA Approval Summary: Nivolumab for the Treatment of Metastatic Non-Small Cell Lung Cancer With Progression On or After Platinum-Based Chemotherapy. The Oncologist 2016;21:1–9.

NSCLC Meta-Analyses Collaborative Group. Chemotherapy in addition to supportive care improves survival in advanced non-small-cell lung cancer: a systematic review and metaanalysis of individual patient data from 16 randomized controlled trials. J Clin Oncol. 2008 Oct 1;26(28):4617-25. doi: 10.1200/JCO.2008.17.7162. Epub 2008 Aug 4. Review.

Reichle A, editor. Evolution-adjusted tumor pathophysiology. Springer 2013, ISBN: 978-94-0076865-9.

Reichle A, editor. From molecular to modular tumor therapy. Springer 2010, ISBN 978-90-4819530-5.

Last updated: june 2018.