Projects

Here you can find a list of projects, which are financially supported by the Anticancer Fund.

Adoptive T cell therapy based on Tumor Infiltrating Lymphocytes for stage IV ovarian cancer

In the USA, impressive results have been obtained in melanoma patients treated with lymphodepleting chemotherapy, followed by ACT with high numbers of ex vivo expanded autologous TIL and IL-2 (cytokine stimulating T cell expansion). The first comparable clinical trial in Europe has not yet been completed, but the results are comparable and promising.
The current project aims to expand this treatment to ovarian cancer patients.

Clinical research: Stimulation of the vagus nerve as a potential cancer treatment

This research aimed to extend the investigation of the role of vagal activity in cancer prognosis.

B-AHEAD-3: a randomized phase-2 trial to determine the effect of a 2 day/week calorie/energy restricted diet and resistance exercise in women receiving chemotherapy for advanced breast cancer

Being overweight or gaining weight due to cancer treatment may have a negative impact on the survival and quality of life of women with breast cancer. Weight loss is therefore recommended in breast cancer patients who are overweight.
A specific diet has been developed that does not only pursue weight loss but also encompasses metabolic changes such as insulin sensitivity, blood pressure, cholesterol, etc.

Clinical research: Sodium bicarbonate

This project evaluated if orally administered Sodium bicarbonate reduces tumor-related pain in patients with malignant solid tumors and hematologic malignancies (Lymphoma and multiple myeloma).

Nitroglycerin as a sensitizer in the treatment of non-small-cell lung cancer: a phase II trial

To study the effect of nitroglycerin in non-small cell lung cancer, 60 patients will be included at MAASTRO clinic.

The use of standardized plant extracts for the treatment of cancer

A plant extract is a complex mixture of different compounds that can act simultaneously on different targets, making it an interesting "cocktail" of natural origin. The Gloriosa superba extract showed promising preclinical activity in a pancreatic mouse model.

FLUVABREX, a phase I study assessing the safety of the association of fluvastatin in addition to celecoxib in children with refractory optic-pathway glioma

Optic-pathway gliomas are rare tumors accounting for 1 to 5% of all brain tumors in children. The current treatment strategy in children with optic glioma symptoms is chemotherapy to postpone radiotherapy on the developing brain of a child as much as possible.
In this Phase I study, the safety of a combination of the 2 drugs celecoxib and fluvastatin in children with optic-pathway gliomas will be verified.

Artemisia annua (Sweet Wormwood)

A project where a specific extract of Artemisia annua was evaluated preclinically as an anticancer therapy.

Ketorolac in Breast Cancer Surgery

There has been recent interest in the possible impact of the perioperative period on cancer outcomes. Several observations have suggested that physiological changes induced by surgery and anesthesia may have an impact on the growth of tumor cells, including a lower risk of breast cancer recurrence.

Clinical research: Randomized phase III trial for T3-4 rectal cancer

Comparison of image-guided radiotherapy with standard chemoradiotherapy in patients with locally advanced rectal cancer.