Projects

Here you can find a list of projects, which are financially supported by the Anticancer Fund.

A phase II Investigation of pembrolizumab (Keytruda) in combination with radiation and an immune modulatory cocktail in patients with cervical and uterine cancer (PRIMMO trial)

The PRIMMO trial aims to improve the treatment for cervical and endometrial cancer patients and uterine sarcoma patients by a combination of 7 therapies which try collectively to support the immune system enabling it to kill the tumour.

PIONEER: a randomised Phase II trial in early stage, operable ER+ breast cancer patients who will receive two weeks of drug treatment prior to surgery.

PIONEER is a randomised Phase II trial in early stage, operable ER+ breast cancer. This is a ‘window of opportunity’ trial in which three groups of post-menopausal women will receive two weeks of drug treatment prior to surgery.

Boost Your Mind: Mindfulness for young adults during and after cancer treatment

This study aimed to examine the feasibility and potential efficacy of MBI for adolescent and young adult cancer (AYAC) survivors and to understand the processes underlying the potential benefits.

CUSP9v3, a combination of 9 repurposed drugs for the treatment of glioblastoma.

In this clinical trial, the combined treatment is given to 10 patients to assess safety of this experimental treatment.

A phase I dose-escalation study of the safety and pharmacokinetics of oral Artesunate in patients with advanced hepatocellular carcinoma

Artesunate (ART) is a water soluble semisynthetic artemisinin with improved pharmacokinetic properties, and is included in the WHO list as an essential drug for the treatment of malaria. The antitumor and antiangiogenic effects of ART were investigated in a carcinogenic-induced mouse model for Hepatocellular carcinoma.

MODULUNG: a prospective phase II, randomized multi-center trial of a biomodulatory treatment with 3 oral drugs in patients with non-small cell lung cancer after platin failure.

This randomized study, where patients are randomly divided over the treatment group and control group, will compare the standard treatment with nivolumab to the experimental treatment with a combination of 3 oral drugs that are currently on the market for other indications than lung cancer.

Clinical research: Adoptive T cell transfer and vaccination as treatment for stage IV melanoma cancer in patients

The activation and expansion of tumor reactive T cells outside the body of patients and their subsequent re-infusion of adoptive cell transfer (ACT) is at this moment the most effective approach to induce objective anti-tumor responses in end-stage metastasized melanoma cancer patients.

Clinical research: Treatment of patients with metastatic melanoma with ultra-low dose Paclitaxel (Taxol®): A Pilot Trial for “Proof of Principle”

A pilot clinical trial to evaluate the biologic effects, safety and efficacy of palliative treatment with ultra-low dose paclitaxel (Taxol®) in patients with metastatic melanoma in stage IV or III unresectable.

Metzolimos, a combination of 4 repurposed drugs studied in patients with advanced solid tumor with bone metastasis and advanced pretreated osteosarcoma.

Metzolimos, metronomic cyclophosphamide and methotrexate combined  with sirolimus and zoledronic acid in patients with advanced solid tumor with bone metastasis and advanced pretreated osteosarcoma.

Translational research: in vivo testing of cryoablation and non-toxic products as a therapeutic treatment for metastatic breast cancer

The main goal of this research project was to develop a non-toxic combination therapy of cryoablation and non-toxic products for efficacy against metastatic breast cancer in the 4T1 model.